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Nutrition: Herbs

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Total 217 results found since Jan 2013.

Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells
Conclusion ER stress related cell apoptosis accounted for the anti-cancer effect of dandelion extract, and these findings support dandelion extract might be a potential therapeutic approach to treat TNBC. Graphical abstract
Source: Journal of Ethnopharmacology - April 29, 2017 Category: Drugs & Pharmacology Source Type: research

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl − /water secretion that involves cAMP-dependent activation of CFTR
AbstractConstipation is a common symptom frequently compromising the quality of daily life. Several mechanistically different drugs have been used to mitigate constipation, including Japanese herbal (Kampo) medicines. However, the mechanisms of their actions are often not well understood. Here we aimed to investigate the molecular mechanisms underlying the effects of Junchoto (JCT), a Kampo medicine empirically prescribed for chronic constipation. Cl− channel activity was measured by the patch-clamp method in human cystic fibrosis transmembrane conductance regulator (CFTR)-expressing HEK293T cells and human intestinal Ca...
Source: Journal of Natural Medicines - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway. PMID: 29632297 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Xihuang Pill Induces Apoptosis of Human Glioblastoma U-87 MG Cells via Targeting ROS-Mediated Akt/mTOR/FOXO1 Pathway.
In conclusion, we demonstrate for the first time that XHP may regulate glioblastoma U-87 MG cell apoptosis via ROS-mediated Akt/mTOR/FOXO1 pathway. PMID: 30046342 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Contribution of human UDP-glucuronosyltransferases to the antioxidant effects of propolis, artichoke and silymarin
Conclusion: In conclusion, this study provides a possible molecular mechanism for protective antioxidant effects associated with the herbal drugs propolis, artichoke and silymarin. The herbal drug-mediated transcriptional upregulation of human detoxifying UGT1A enzymes via activation of AhR and Nrf2 leads to reduced hydrogen peroxide and oxidative stress. Because of UGT1A activation, the intake of these drugs could affect the therapeutic efficacy of other drugs when these also undergo metabolism by glucuronidation.Graphical abstract
Source: Phytomedicine - August 10, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of berberine on high glucose and hypoxia-induced apoptosis via the modulation of HIF-1 α in renal tubular epithelial cells.
Protective effect of berberine on high glucose and hypoxia-induced apoptosis via the modulation of HIF-1α in renal tubular epithelial cells. Am J Transl Res. 2019;11(2):669-682 Authors: Zhang X, Guan T, Yang B, Chi Z, Wan Q, Gu HF Abstract Berberine (BBR), derived from Huanglian (Coptis chinensis), is a traditional Chinese herbal medicine. In the current study, we investigated the effects of BBR in high glucose (HG) and hypoxia-induced apoptosis with normal rat renal tubular epithelial (NRK-52E) and human kidney proximal tubular cells (HK-2) and further explored the underlying molecular mechanism of h...
Source: American Journal of Translational Research - March 24, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation
ConclusionsThe present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways.Graphical abstract
Source: Biomedicine and Pharmacotherapy - July 12, 2019 Category: Drugs & Pharmacology Source Type: research

Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation.
CONCLUSIONS: The present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways. PMID: 31302422 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2019 Category: Drugs & Pharmacology Authors: Fan L, Li M, Cao FY, Zeng ZW, Li XB, Ma C, Ru JT, Wu XJ Tags: Biomed Pharmacother Source Type: research

Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
CONCLUSIONS Our results confirm that OMT alleviates transdifferentiation of cardiac fibroblasts to myofibroblasts induced by aldosterone via activating the Nrf2/Keap1 pathway in vitro. PMID: 31325292 [PubMed - in process]
Source: Medical Science Monitor - July 21, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of aconitum alkaloids
ConclusionsThese results demonstrate that a novel proton-coupled organic cation antiporter plays a predominant role in the blood to brain influx of AC, MA and HA at the BBB, and thus affect the safety of Aconitum species.Graphical abstract
Source: Journal of Ethnopharmacology - January 20, 2020 Category: Drugs & Pharmacology Source Type: research

Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells Research Articles
Geranylgeranoic acid (GGA) originally was identified in some animals and has been developed as an agent for preventing second primary hepatoma. We previously have also identified GGA as an acyclic diterpenoid in some medicinal herbs. Recently, we reported that in human hepatoma-derived HuH-7 cells, GGA is metabolically labeled from 13C-mevalonate. Several cell-free experiments have demonstrated that GGA is synthesized through geranylgeranial by oxygen-dependent oxidation of geranylgeraniol (GGOH), but the exact biochemical events giving rise to GGA in hepatoma cells remain unclear. Monoamine oxidase B (MOAB) has been sugge...
Source: The Journal of Lipid Research - April 30, 2020 Category: Lipidology Authors: Tabata, Y., Shidoji, Y. Tags: Research Articles Source Type: research

Glycyrrhetinic Acid Protects Renal Tubular Cells against Oxidative Injury via Reciprocal Regulation of JNK-Connexin 43-Thioredoxin 1 Signaling
Conclusion: ROS-JNK-Cx43-thioredoxin 1 signaling plays a crucial role in renal tubular cell injury. JNK is involved in the regulation of thioredoxin 1 and Cx43, and Cx43 reciprocally regulates thioredoxin 1. Inhibition of gap junctions by Ga alleviated renal tubular oxidative injury via improvement of thioredoxin 1-mediated redox signaling.
Source: Frontiers in Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research