A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of aconitum alkaloids

ConclusionsThese results demonstrate that a novel proton-coupled organic cation antiporter plays a predominant role in the blood to brain influx of AC, MA and HA at the BBB, and thus affect the safety of Aconitum species.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionThree-dimensional visualization of opened coronary microvascular vessels is feasible in DiI-labelled myocardium in this rat MI model. This novel technique might be useful for defining the underlying mechanisms of coronary microvascular diseases and observe the efficacy of various therapy strategies on coronary microvessels.
Source: Microvascular Research - Category: Biochemistry Source Type: research
CONCLUSIONS: An HBOC-201-EVNLP produced outcomes similar to RBC-EVNLP with preservation of muscle contractility and mitochondrial structure. PMID: 32074378 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Gurney JM, Loos PE, Prins M, Van Wyck DW, McCafferty RR, Marion DW Abstract Increased resource constraints secondary to a smaller medical footprint, prolonged evacuation times, or overwhelming casualty volumes all increase the challenges of effective management of traumatic brain injury (TBI) in the austere environment. Prehospital providers are responsible for the battlefield recognition and initial management of TBI. As such, targeted education is critical to efficient injury recognition, promoting both provider readiness and improved patient outcomes. When austere conditions limit or prevent definitive ...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
CONCLUSION: We conclude that CEUS has the spatial and temporal sensitivity and resolution to visualize local tissue perfusion and vessel architecture, which maybe useful clinically to determine injury extent and severity in patients with SCI. PMID: 32074323 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Conclusion: First, washout and myogenic effects both influence the hepatic arterial buffer response; and second, hepatic sinusoidal pressure levels strongly influence the hepatic arterial resistance. Significance: These results present new findings in - emodynamics of the liver, which are fundamental for successful ex vivo liver perfusion.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
FRIDAY, Feb. 21, 2020 -- Reduced myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) are prognostic for patients with coronary artery disease, according to a study published online Feb. 14 in Circulation. Kristopher D. Knott,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
An artificial intelligence (AI) algorithm that quantifies blood flow on cardiac...Read more on AuntMinnie.comRelated Reading: What can AI do to speed up cardiac MRI interpretations? AI can find patients at risk for MRI safety issues Advances in imaging, AI make cardiac MRI more accessible Is perfusion MRI best to rule on revascularization? AI model could enable gadolinium-free cardiac MRI
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Wang, K. Chang, H. Zhou, J. Wu, G. Cohan, M. Jayaraman, R. Huang, J. Boxerman, L. Yang, F. Hui, J. Woo, H. Bai
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Real-time bedside information on regional ventilation and perfusion during mechanical ventilation (MV) may help to elucidate the physiological and pathophysiological effects of MV settings in healthy and injur...
Source: Intensive Care Medicine Experimental - Category: Surgery Authors: Tags: Research Source Type: research
The objective of this study was to assess and characterize the tissue distribution of SHetA2 in tumor-bearing mice by developing a physiologically based pharmacokinetic (PBPK) model. An orthotopic SKOV3 ovarian cancer xenograft mouse model was used to most accurately mimic the ovarian cancer tumor microenvironment in the peritoneal cavity. SHetA2 concentrations in plasma and 14 different tissues were measured at various time points after a single intravenous dose of 10  mg/kg and oral dose of 60 mg/kg, and these data were used to develop a whole-body PBPK model. SHetA2 exhibited a multi-exponential plasma concent...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
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