Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

In conclusion, Rg3 induces tumor cell apoptosis correlated with its inhibitory effect on NF-κB signaling pathway-mediated FUT4 expression. Results suggest Rg3 might be a novel therapy agent for melanoma treatment.
PMID: 26094873 [PubMed - as supplied by publisher]

Source: International Journal of Oncology - June 18, 2015 Category: Cancer & Oncology Authors: Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research