Synthesis, anticonvulsant screening, and molecular modeling studies of new arylalkylimidazole oxime ether derivatives
In this study, 15 new oxime ether derivatives were synthesized and their anticonvulsant activities were screened in vivo. The compounds were synthesized by the reaction of various alkyl halides with 1 ‐(2‐naphthyl)‐2‐(1H‐imidazol‐1‐yl)ethanone oxime. Their anticonvulsant activities were determined using acute (maximal electroshock, subcutaneous metrazol [SCM], and 6 Hz seizure test) and chronic (corneal‐kindled mouse) seizure models, their neurotoxic effects were evaluated by models of behavioral toxicity a ccording to the Epilepsy Therapy Screening Program protocol of the NIH. All our compounds were protec...
Source: Drug Development Research - November 25, 2018 Category: Drugs & Pharmacology Authors: Zeynep Özdemir, Suat Sari, Arzu Karakurt, Sevim Dalkara Tags: RESEARCH ARTICLE Source Type: research

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma
Abstract Preclinical Research& DevelopmentAsthma is termed as the induction of chronic inflammation in the airway lumen of lungs due to accumulation of inflammatory cells which affects normal breathing process. Prolonged accumulation of inflammatory cells leads to oxidative stress and suppression of antioxidant activities. Therefore, in our present investigation, a potential phenolic compound, Syringic acid was tested for the suppression of inflammatory markers toward an antiasthmatic activity in ovalbumin (OVA) ‐induced asthmatic mice model. As a result, the Syringic acid treatment was found to suppress the inflamm...
Source: Drug Development Research - November 25, 2018 Category: Drugs & Pharmacology Authors: Yinfang Li, Li Zhang, Xiaohua Wang, wei wu, Rui Qin Tags: RESEARCH ARTICLE Source Type: research

Microsponge: An emerging drug delivery strategy
Abstract Hit, Lead& Candidate DiscoveryMicrosponges are the spherical particles ranging from 5 to 300  μm in size. These are further made up of clusters of smaller spheres. They are designed for delivering the drug efficiently at a comparatively lesser dose and enhancing the stability, modifying the drug release profile and minimizing the side effects. Microsponge drug delivery system decrease tr ansdermal invasion of the active ingredient into the skin while increasing the time the drug remains on the skin surface or within the epidermis. Preparation of the microsponges includes two techniques: Liquid–liquid sus...
Source: Drug Development Research - November 19, 2018 Category: Drugs & Pharmacology Authors: Gautam Singhvi, Prachi Manchanda, Neha Hans, Sunil K. Dubey, Gaurav Gupta Tags: OVERVIEW Source Type: research

Drug sales confirm clinical advantage of multi ‐target inhibition of drug escapes by anticancer kinase inhibitors
Abstract Hit, Lead& Candidate DiscoveryThe clinical advantage of co ‐targeting cancer drug escape has been indicated by the percentage of these co‐targeting drugs among all multi‐target drugs in clinics and clinical trials. This clinical advantage needs to be further interrogated from such perspectives as the clinical impact of multi‐target inhibition of dru g‐escape mediators. This impact may be reflected by drug sales data, that is, multi‐target inhibition of higher number of drug‐escape mediators favors the expanded coverage of drug‐resistant patients leading to higher sales. We investigated whether...
Source: Drug Development Research - November 13, 2018 Category: Drugs & Pharmacology Authors: Shangying Chen, Sheng Yong Yang, Zhe Chen, Ying Tan, Yu Yang Jiang, Yu Zong Chen Tags: RESEARCH ARTICLE Source Type: research

Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol ‐bound punicic acid for increased antihepatotoxic activity
Abstract Hit, Lead& Candidate DiscoveryPunicic acid of pomegranate oil (PAP) has gained heightened interest due to several health benefits, such as anticarcinogenic, antidiabetic, and antiatherosclerotic properties. However, these bioactivities have been hampered by chemical instability, poor water solubility, rapid metabolism, and low bioavailability of PAP. Therefore, this study was aimed at optimizing the liposomal formulation of Triacylglycerol ‐bound punicic acid with its regioisomers (TPAR) for improved oral bioavailability and increased hepatoprotection through antioxidation and anti‐inflammation. Herein, t...
Source: Drug Development Research - November 10, 2018 Category: Drugs & Pharmacology Authors: Michael Adu ‐Frimpong, Caleb Kesse Firempong, Emmanuel Omari‐Siaw, Qilong Wang, Yusif Mohammed Mukhtar, Wenwen Deng, Qingtong Yu, Ximing Xu, Jiangnan Yu Tags: RESEARCH ARTICLE Source Type: research

Issue Information ‐ TOC
Drug Development Research, Volume 79, Issue 7, Page 313-313, November 2018. (Source: Drug Development Research)
Source: Drug Development Research - November 9, 2018 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Cover Image, Volume 79, Issue 7
Drug Development Research, Volume 79, Issue 7, Page i-i, November 2018. (Source: Drug Development Research)
Source: Drug Development Research - November 9, 2018 Category: Drugs & Pharmacology Tags: Cover Image Source Type: research

Functional mechanism of tracheal relaxation, antiasthmatic, and toxicological studies of 6 ‐hydroxyflavone
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - November 5, 2018 Category: Drugs & Pharmacology Authors: Ang élica Flores‐Flores, Samuel Estrada‐Soto, César Millán‐Pacheco, Blanca Bazán‐Perkins, Rafael Villalobos‐Molina, Leticia Moreno‐Fierros, Rogelio Hernández‐Pando, Sara García‐Jiménez, Julio César Rivera‐Leyva Source Type: research

Silver carbene complexes: An emerging class of anticancer agents
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - November 2, 2018 Category: Drugs & Pharmacology Authors: Shravankumar Kankala, Niranjan Thota, Fredrik Bj örkling, Myles K. Taylor, Ravinder Vadde, Ramesh Balusu Source Type: research

Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5 ′‐monophosphate dehydrogenase (HpIMPDH) inhibitors
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - November 1, 2018 Category: Drugs & Pharmacology Authors: Niteshkumar U. Sahu, Gayathri Purushothaman, Vijay Thiruvenkatam, Prashant S. Kharkar Source Type: research

Protective role of fucoxanthin in diethylnitrosamine ‐induced hepatocarcinogenesis in experimental adult rats
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - October 31, 2018 Category: Drugs & Pharmacology Authors: Xin Jin, TingTing Zhao, Dan Shi, Ming Bao Ye, Qiying Yi Source Type: research

Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - October 30, 2018 Category: Drugs & Pharmacology Authors: Estefan ía Burgos‐Morón, Nuria Pastor, Manuel Luis Orta, Julio José Jiménez‐Alonso, Margarita Vega‐Holm, José Manuel Vega‐Pérez, Fernando Iglesias‐Guerra, Santiago Mateos, Miguel López‐Lázaro, José Manuel Calderón‐Montaño Source Type: research

Marine bacteria and fungi as promising source for new antibiotics
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - October 29, 2018 Category: Drugs & Pharmacology Authors: Jutta Wiese, Johannes F. Imhoff Source Type: research

Antibiotics as both friends and foes of the human gut microbiome: The microbial community approach
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - October 29, 2018 Category: Drugs & Pharmacology Authors: Teresa Nogueira, Pedro H. C. David, Jo ël Pothier Source Type: research

Participation of ATP ‐sensitive K+ channels and μ‐opioid receptors in the antinociceptive synergism of the paracetamol–tapentadol co‐administration in the formalin‐induced pain assay in mice
Drug Development Research, EarlyView. (Source: Drug Development Research)
Source: Drug Development Research - October 26, 2018 Category: Drugs & Pharmacology Authors: Juan R. Zapata ‐Morales, Ángel J. Alonso‐Castro, Salud Pérez‐Gutiérrez, Edgar Isaac Rojas‐Bedolla, Sergio Sánchez‐Enriquez, Jorge David Rivas‐Carrillo, Nicolás A. Serafín‐Higuera, Mario A. Isiordia‐Espinoza Source Type: research