Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells

Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.

http://www.biomedcentral.com/1472-6882/14/68

Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research