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Perturbed ER homeostasis by IGF-IIR α promotes cardiac damage under stresses
In this study, we investigate the molecular mechanism and contribution of IGF-IIRα in endoplasmic reticulum stress induction in the heart under doxorubicin-induced cardiotoxicity. Using in vitro H9c2 cells, in vivo transgenic rat cardiac tissues, siRNAs against CHOP, chemical ER chaperone PBA, and western blot experiments, we found that IGF-IIRα overexpression enhanced ER stress markers ATF4, ATF6, IRE1α, and PERK which were further aggravated by DOX treatment. This was accompanied by a significant perturbation in stress-associated MAPKs such as p38 and JNK. Interestingly, PARKIN, a stress responsive cellular protective...
Source: Molecular and Cellular Biochemistry - September 29, 2021 Category: Biochemistry Authors: Sudhir Pandey Chia-Hua Kuo William Shao-Tsu Chen Yu-Lan Yeh Wei-Wen Kuo Ray-Jade Chen Cecilia Hsuan Day Pei-Ying Pai Tsung-Jung Ho Chih-Yang Huang Source Type: research

Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research

Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma
Biomed Pharmacother. 2021 May 26;140:111701. doi: 10.1016/j.biopha.2021.111701. Online ahead of print.ABSTRACTPatients with chronic obstructive asthma (COA) develop airflow obstruction caused by subepithelial fibrosis. Although a disintegrin and metalloproteinase 17 (ADAM17) has been implicated in lung inflammation and tissue fibrosis, its role in airway fibrosis in COA has not been explored. Here, we found marked overexpression of ADAM17, phosphorylated ADAM17, and connective tissue growth factor (CTGF) in human airway fibroblasts from COA patients, compared with those of normal subjects. Similarly, levels of ADAM17, CTGF...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2021 Category: Drugs & Pharmacology Authors: Jing-Yun Chen Wun-Hao Cheng Kang-Yun Lee Han-Pin Kuo Kian Fan Chung Chia-Ling Chen Bing-Chang Chen Chien-Huang Lin Source Type: research

Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer Molecular Bases of Disease
In this study, we discovered that combined p53- and PTEN-deficiency in TNBC activates expression of the transcription factor mesenchyme homeobox 1 (MEOX1). We found that MEOX1 is expressed only in TNBC cells with frequent deficiencies in p53 and PTEN, and that its expression is undetectable in luminal A, luminal B, and HER2+ subtypes, as well as in normal breast cells with wild-type (WT) p53 and PTEN. Notably, siRNA knockdown of both p53 and PTEN activated MEOX1 expression in breast cancer cells, whereas individual knockdowns of either p53 or PTEN had only minimal effects on MEOX1 expression. MEOX1 knockdown abolished cell...
Source: Journal of Biological Chemistry - August 20, 2020 Category: Chemistry Authors: Mari Gasparyan, Miao-Chia Lo, Hui Jiang, Chang-Ching Lin, Duxin Sun Tags: Molecular Bases of Disease Source Type: research

FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells
Conclusions: Our data therefore demonstrate the importance of FGF9 in the determination of SC fate via the FGF9-FGFR2-Akt pathway and reveal the therapeutic benefit of FGF9-NLCs.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chia-Wei Huang, Shih-Yu Lu, Tzu-Chieh Huang, Bu-Miim Huang, H. Sunny Sun, Shang-Hsun Yang, Jih-Ing Chuang, Yuan-Yu Hsueh, Yi-Ting Wu, Chia-Ching Wu Tags: Research Paper Source Type: research

Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium
In conclusion, interleukin-6 played an important role in aldosterone-induced macrophage recruitment and infiltration in the myocardium.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 28, 2019 Category: Molecular Biology Source Type: research

In vitro siRNA delivery via diethylenetriamine- and tetraethylenepentamine-modified carboxyl group-terminated Poly(amido)amine generation 4.5 dendrimers
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Endiries Yibru Hanurry, Wei-Hsin Hsu, Haile Fentahun Darge, Yihenew Simegniew Birhan, Tefera Worku Mekonnen, Abegaz Tizazu Andrgie, Hsiao-Ying Chou, Chih-Chia Cheng, Juin-Yih Lai, Hsieh-Chih TsaiAbstractThe recent discovery of small interfering RNAs (siRNAs) has opened new avenues for designing personalized treatment options for various diseases. However, the therapeutic application of siRNAs has been confronted with many challenges because of short half-life in circulation, poor membrane penetration, difficulty in escaping fro...
Source: Materials Science and Engineering: C - October 18, 2019 Category: Materials Science Source Type: research

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.Graphical abstractThis diagram illustrated that quercetin treatment effectively attenuated RAGE expression to facilitate autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 and MIA Paca-2 GEMR cells.
Source: Journal of Food and Drug Analysis - August 22, 2019 Category: Food Science Source Type: research

Role of PGRMC1 in cell physiology of cervical cancer
In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed...
Source: Life Sciences - June 18, 2019 Category: Biology Source Type: research

An Open‐Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM‐080301 in Subjects with Advanced Hepatocellular Carcinoma
Conclusion.TKM‐080301 was generally well tolerated. In this early‐phase study, antitumor effect for TKM 080301 was limited. Further evaluation as a single agent in large randomized trials is not warranted.
Source: The Oncologist - June 17, 2019 Category: Cancer & Oncology Authors: Imane El Dika, Ho Yeong Lim, Wei Peng Yong, Chia-Chi Lin, Jung-Hwan Yoon, Manuel Modiano, Bradley Freilich, Hye Jin Choi, Tsu-Yi Chao, Robin K. Kelley, Joanne Brown, Jennifer Knox, Baek-Yeol Ryoo, Thomas Yau, Ghassan K. Abou-Alfa Tags: Hepatobiliary, Chinese Edition, Clinical Trial Results Source Type: research

Epidermal growth factor ‐containing fibulin‐like extracellular matrix protein 1 (EFEMP1) suppressed the growth of hepatocellular carcinoma cells by promoting Semaphorin 3B(SEMA3B)
ConclusionIn summary, our research revealed the regulation of EFEMP1 on cell proliferation and apoptosis in HCC. EFEMP1 may suppress the growth of HCC cells by promoting SEMA3B.
Source: Cancer Medicine - April 10, 2019 Category: Cancer & Oncology Authors: Jiangfeng Hu, Bensong Duan, Weiliang Jiang, Sengwang Fu, Hengjun Gao, Lungen Lu Tags: ORIGINAL RESEARCH Source Type: research

GSE115270 Differential expression profiling of the TamR cells following AR knockdown
In this study, we sought to characterize the functional consequences of AR knockdown using a siRNA-mediated approach in a tamoxifen-resistant (TamR) derivative of MCF7 breast cancer cell line.
Source: GEO: Gene Expression Omnibus - June 5, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.
Abstract The capacity of G protein-coupled receptors to modulate mammalian target of rapamycin (mTOR) activity is a newly emerging paradigm with the potential to link cell surface receptors with cell survival. Cardiomyocyte viability is linked to signaling pathways involving Akt and mTOR, as well as increased glucose uptake and utilization. Our aim was to determine whether the α1A-adrenoceptor (AR) couples to these protective pathways, and increased glucose uptake. We characterised α1A-AR signalling in CHO-K1 cells co-expressing the human α1A-AR and GLUT4 (CHOα1AGLUT4myc) and in neonatal rat ventricular cardio...
Source: Biochemical Pharmacology - November 23, 2017 Category: Drugs & Pharmacology Authors: Sato M, Evans BA, Sandström AL, Yeong Chia L, Mukaida S, San Thai B, Nguyen A, Lim L, Yr Tan C, Baltos JA, White PJ, May LT, Hutchinson DS, Summers RJ, Bengtsson T Tags: Biochem Pharmacol Source Type: research

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