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Total 53 results found since Jan 2013.
Small interfering RNA targeting N-cadherin regulates cell proliferation and migration in enzalutamide-resistant prostate cancer
Oncol Lett. 2022 Mar;23(3):90. doi: 10.3892/ol.2022.13210. Epub 2022 Jan 21.ABSTRACTEnzalutamide is one of the options for treating patients with castration-resistant or metastatic prostate cancer. However, a substantial proportion of patients become resistant to enzalutamide after a period of treatment. Cells in these tumors typically exhibit increased proliferative and migratory capabilities, in which N-cadherin (CDH2) appear to serve an important role. In the present study, by up- and downregulating the expression of CDH2, the possible effects of CDH2 on the prostate cancer cell line LNCaP were investigated. Male sex ho...
Source: Oncology Letters - February 7, 2022 Category: Cancer & Oncology Authors: Cheng-Hsin Lu Chun-Hsien Wu Pei-Fang Hsieh Chen-Yu Wu Wade Wei-Ting Kuo Chien-Hui Ou Victor Chia Hsiang Lin Source Type: research
Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition
In this study, we hypothesized that CAP regulates monocyte accessibility by influencing their adhesion to endothelial cells. Using RNA-seq analysis, we identified that α1,3-Fucosyltransferase 7 (FucT-VII), the enzyme required for processing selectin ligands, was significantly downregulated by α7nAChR agonist among other cell-cell adhesion genes. The α7nAChR agonist inhibited monocytic cell line U-937 binding to P-selectin and adhesion to endothelial cells. Furthermore, α7nAChR agonist selectivity was confirmed by α7nAChR knockdown assays, showing that FUT7 inhibition and adhesion attenuation by the agonist was abolish...
Source: Biochemical and Biophysical Research communications - January 1, 2022 Category: Biochemistry Authors: Chia-Hsien Wu Tsuyoshi Inoue Yasuna Nakamura Rie Uni Sho Hasegawa Hiroshi Maekawa Mai Sugahara Youichiro Wada Tetsuhiro Tanaka Masaomi Nangaku Reiko Inagi Source Type: research
Heterogeneous multi-compartmental DNA hydrogel particles prepared < em > via < /em > microfluidic assembly for lymphocyte-inspired precision medicine
Nanoscale. 2021 Dec 3. doi: 10.1039/d1nr06594g. Online ahead of print.ABSTRACTLymphocytes play a vital role in immunosurveillance through sensing biomolecules and eliminating targeted invaders. Compared with conventional therapies that depend on drug loading, lymphocytes are advantageous as they are able to ensure self-regulated therapeutics. Here, novel multi-compartmental DNA hydrogel particles were synthesized using a microfluidic assembly for intelligent cancer treatment via the logic-based control of siRNA release without external stimulation. The sensing sequence (D1) was compartmentalized from the treatment sequence...
Source: Cancer Control - December 3, 2021 Category: Cancer & Oncology Authors: Sophie Wan Mei Lian Song Guo Kewei Ren Ying Xu John S Ho Chia-Hung Chen Source Type: research
Cancers, Vol. 13, Pages 5779: Kinome-Wide siRNA Screening Identifies DYRK1B as a Potential Therapeutic Target for Triple-Negative Breast Cancer Cells
Conclusions: our results suggest DYRK1B might be essential for promoting tumor progression and could be a theranostic target for TNBC. Silencing or inactivation of DYRK1B might be a potential targeted therapy for TNBC.
Source: Cancers - November 18, 2021 Category: Cancer & Oncology Authors: Chia-Che Chang Chien-Chih Chiu Pei-Feng Liu Chih-Hsuan Wu Yen-Chiang Tseng Cheng-Hsin Lee Chih-Wen Shu Tags: Article Source Type: research
Perturbed ER homeostasis by IGF-IIR α promotes cardiac damage under stresses
In this study, we investigate the molecular mechanism and contribution of IGF-IIRα in endoplasmic reticulum stress induction in the heart under doxorubicin-induced cardiotoxicity. Using in vitro H9c2 cells, in vivo transgenic rat cardiac tissues, siRNAs against CHOP, chemical ER chaperone PBA, and western blot experiments, we found that IGF-IIRα overexpression enhanced ER stress markers ATF4, ATF6, IRE1α, and PERK which were further aggravated by DOX treatment. This was accompanied by a significant perturbation in stress-associated MAPKs such as p38 and JNK. Interestingly, PARKIN, a stress responsive cellular protective...
Source: Molecular and Cellular Biochemistry - September 29, 2021 Category: Biochemistry Authors: Sudhir Pandey Chia-Hua Kuo William Shao-Tsu Chen Yu-Lan Yeh Wei-Wen Kuo Ray-Jade Chen Cecilia Hsuan Day Pei-Ying Pai Tsung-Jung Ho Chih-Yang Huang Source Type: research
