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Total 53 results found since Jan 2013.
PIEZO1 promotes ATP release from periodontal ligament cells following compression force
CONCLUSIONS: PIEZO1 on the cell membranes of HPdLFs is activated by compression force and then induces ATP release via intracellular Ca2+-dependent exocytosis and ATP-permeable channels.PMID:37632763 | DOI:10.1093/ejo/cjad052
Source: European Journal of Orthodontics - August 26, 2023 Category: Dentistry Authors: Seiwa Horie Chihiro Nakatomi Misa Ito-Sago Aoi Morii Ai Orimoto Hiroshi Ikeda Chia-Chien Hsu Mako Naniwa Masahiro Mizuhara Kaori Gunjigake Tatsuo Kawamoto Kentaro Ono Source Type: research
CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells
J Cell Mol Med. 2023 Apr 21. doi: 10.1111/jcmm.17750. Online ahead of print.ABSTRACTHuman oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased ...
Source: J Cell Mol Med - April 21, 2023 Category: Molecular Biology Authors: Chia-Yu Wu Pei-Wen Peng Ting-Yi Renn Chia-Jung Lee Tsung-Ming Chang Augusta I-Chin Wei Ju-Fang Liu Source Type: research
Amphiregulin induces CCN2 and fibronectin expression by TGF- β through EGFR-dependent pathway in lung epithelial cells
CONCLUSION: These results suggested that AREG mediates the TGF-β-induced EMT in human lung epithelial cells through EGFR/JNK/AP-1 activation. Understanding the role of AREG in the EMT could foster the development of therapeutic strategies for airway remodeling in severe asthma.PMID:36578010 | DOI:10.1186/s12931-022-02285-2
Source: Cell Research - December 28, 2022 Category: Cytology Authors: Wun-Hao Cheng Shih-Ya Kao Chia-Ling Chen Fara Silvia Yuliani Lee-Yuan Lin Chien-Huang Lin Bing-Chang Chen Source Type: research
A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant
EMBO Mol Med. 2022 Feb 8:e15298. doi: 10.15252/emmm.202115298. Online ahead of print.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has altered the trajectory of the COVID-19 pandemic and raised some uncertainty on long term efficiency of vaccine strategy. The development of new therapeutics against a wide range of SARS-CoV-2 variants is imperative. We here have designed an inhalable siRNA, C6G25S, which covers 99.8% of current SARS-CoV-2 variants and is capable of inhibiting dominant strains, including Alpha, Delta, Gamma and Epsilon, at picomolar ranges of IC50 in vitro. Mo...
Source: Molecular Medicine - February 9, 2022 Category: Molecular Biology Authors: Yi-Chung Chang Chi-Fan Yang Yi-Fen Chen Chia-Chun Yang Yuan-Lin Chou Hung-Wen Chou Tein-Yao Chang Tai-Ling Chao Shu-Chen Hsu Si-Man Ieong Ya-Min Tsai Ping-Cheng Liu Yuan-Fan Chin Jun-Tung Fang Han-Chieh Kao Hsuan-Ying Lu Jia-Yu Chang Ren-Shiuan Weng Qian- Source Type: research
Small interfering RNA targeting N-cadherin regulates cell proliferation and migration in enzalutamide-resistant prostate cancer
Oncol Lett. 2022 Mar;23(3):90. doi: 10.3892/ol.2022.13210. Epub 2022 Jan 21.ABSTRACTEnzalutamide is one of the options for treating patients with castration-resistant or metastatic prostate cancer. However, a substantial proportion of patients become resistant to enzalutamide after a period of treatment. Cells in these tumors typically exhibit increased proliferative and migratory capabilities, in which N-cadherin (CDH2) appear to serve an important role. In the present study, by up- and downregulating the expression of CDH2, the possible effects of CDH2 on the prostate cancer cell line LNCaP were investigated. Male sex ho...
Source: Oncology Letters - February 7, 2022 Category: Cancer & Oncology Authors: Cheng-Hsin Lu Chun-Hsien Wu Pei-Fang Hsieh Chen-Yu Wu Wade Wei-Ting Kuo Chien-Hui Ou Victor Chia Hsiang Lin Source Type: research
