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Total 53 results found since Jan 2013.

In vitro siRNA delivery via diethylenetriamine- and tetraethylenepentamine-modified carboxyl group-terminated Poly(amido)amine generation 4.5 dendrimers
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Endiries Yibru Hanurry, Wei-Hsin Hsu, Haile Fentahun Darge, Yihenew Simegniew Birhan, Tefera Worku Mekonnen, Abegaz Tizazu Andrgie, Hsiao-Ying Chou, Chih-Chia Cheng, Juin-Yih Lai, Hsieh-Chih TsaiAbstractThe recent discovery of small interfering RNAs (siRNAs) has opened new avenues for designing personalized treatment options for various diseases. However, the therapeutic application of siRNAs has been confronted with many challenges because of short half-life in circulation, poor membrane penetration, difficulty in escaping fro...
Source: Materials Science and Engineering: C - October 18, 2019 Category: Materials Science Source Type: research

Cancers, Vol. 13, Pages 5779: Kinome-Wide siRNA Screening Identifies DYRK1B as a Potential Therapeutic Target for Triple-Negative Breast Cancer Cells
Conclusions: our results suggest DYRK1B might be essential for promoting tumor progression and could be a theranostic target for TNBC. Silencing or inactivation of DYRK1B might be a potential targeted therapy for TNBC.
Source: Cancers - November 18, 2021 Category: Cancer & Oncology Authors: Chia-Che Chang Chien-Chih Chiu Pei-Feng Liu Chih-Hsuan Wu Yen-Chiang Tseng Cheng-Hsin Lee Chih-Wen Shu Tags: Article Source Type: research

Nanoparticle Delivered VEGF-A siRNA Enhances Photodynamic Therapy for Head and Neck Cancer Treatment
h-Chih Hsu
Source: Molecular Therapy - February 8, 2016 Category: Genetics & Stem Cells Authors: Rumwald Leo G LecarosLeaf HuangTsai-Chia LeeYih-Chih Hsu Source Type: research

A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant
EMBO Mol Med. 2022 Feb 8:e15298. doi: 10.15252/emmm.202115298. Online ahead of print.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has altered the trajectory of the COVID-19 pandemic and raised some uncertainty on long term efficiency of vaccine strategy. The development of new therapeutics against a wide range of SARS-CoV-2 variants is imperative. We here have designed an inhalable siRNA, C6G25S, which covers 99.8% of current SARS-CoV-2 variants and is capable of inhibiting dominant strains, including Alpha, Delta, Gamma and Epsilon, at picomolar ranges of IC50 in vitro. Mo...
Source: Molecular Medicine - February 9, 2022 Category: Molecular Biology Authors: Yi-Chung Chang Chi-Fan Yang Yi-Fen Chen Chia-Chun Yang Yuan-Lin Chou Hung-Wen Chou Tein-Yao Chang Tai-Ling Chao Shu-Chen Hsu Si-Man Ieong Ya-Min Tsai Ping-Cheng Liu Yuan-Fan Chin Jun-Tung Fang Han-Chieh Kao Hsuan-Ying Lu Jia-Yu Chang Ren-Shiuan Weng Qian- Source Type: research

Amphiregulin induces CCN2 and fibronectin expression by TGF- β through EGFR-dependent pathway in lung epithelial cells
CONCLUSION: These results suggested that AREG mediates the TGF-β-induced EMT in human lung epithelial cells through EGFR/JNK/AP-1 activation. Understanding the role of AREG in the EMT could foster the development of therapeutic strategies for airway remodeling in severe asthma.PMID:36578010 | DOI:10.1186/s12931-022-02285-2
Source: Cell Research - December 28, 2022 Category: Cytology Authors: Wun-Hao Cheng Shih-Ya Kao Chia-Ling Chen Fara Silvia Yuliani Lee-Yuan Lin Chien-Huang Lin Bing-Chang Chen Source Type: research

14-3-3sigma induces heat shock protein 70 expression in hepatocellular carcinoma
Conclusions: Our findings indicate that 14-3-3sigma participates in promoting HCC cell migration and tumor development via beta-catenin/HSF-1alpha/HSP70 pathway regulation. Thus, 14-3-3sigma alone or combined with HSP70 are potential prognostic biomarkers for HCC.
Source: BMC Cancer - June 12, 2014 Category: Cancer & Oncology Authors: Chia-Chia LiuYee-Jee JanBor-Sheng KoYao-Ming WuShu-Man LiangShyh-Chang ChenYen-Ming LeeTzu-An LiuTzu-Ching ChangJohn WangSong-Kun ShyueLi-Ying SungJun-Yang Liou Source Type: research

Heterogeneous multi-compartmental DNA hydrogel particles prepared < em > via < /em > microfluidic assembly for lymphocyte-inspired precision medicine
Nanoscale. 2021 Dec 3. doi: 10.1039/d1nr06594g. Online ahead of print.ABSTRACTLymphocytes play a vital role in immunosurveillance through sensing biomolecules and eliminating targeted invaders. Compared with conventional therapies that depend on drug loading, lymphocytes are advantageous as they are able to ensure self-regulated therapeutics. Here, novel multi-compartmental DNA hydrogel particles were synthesized using a microfluidic assembly for intelligent cancer treatment via the logic-based control of siRNA release without external stimulation. The sensing sequence (D1) was compartmentalized from the treatment sequence...
Source: Cancer Control - December 3, 2021 Category: Cancer & Oncology Authors: Sophie Wan Mei Lian Song Guo Kewei Ren Ying Xu John S Ho Chia-Hung Chen Source Type: research

Small interfering RNA targeting N-cadherin regulates cell proliferation and migration in enzalutamide-resistant prostate cancer
Oncol Lett. 2022 Mar;23(3):90. doi: 10.3892/ol.2022.13210. Epub 2022 Jan 21.ABSTRACTEnzalutamide is one of the options for treating patients with castration-resistant or metastatic prostate cancer. However, a substantial proportion of patients become resistant to enzalutamide after a period of treatment. Cells in these tumors typically exhibit increased proliferative and migratory capabilities, in which N-cadherin (CDH2) appear to serve an important role. In the present study, by up- and downregulating the expression of CDH2, the possible effects of CDH2 on the prostate cancer cell line LNCaP were investigated. Male sex ho...
Source: Oncology Letters - February 7, 2022 Category: Cancer & Oncology Authors: Cheng-Hsin Lu Chun-Hsien Wu Pei-Fang Hsieh Chen-Yu Wu Wade Wei-Ting Kuo Chien-Hui Ou Victor Chia Hsiang Lin Source Type: research