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Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression
Forkhead box C1 (FOXC1) is a member of the forkhead family of transcription factors that are characterized by a DNA-binding forkhead domain. Increasing evidence indicates that FOXC1 is involved in tumor progression. However, the role of tumor hypoxia in FOXC1 regulation and its impact on lung cancer progression are unclear. Here, we report that FOXC1 was upregulated in hypoxic areas of lung cancer tissues from rodents or humans. Hypoxic stresses significantly induced FOXC1 expression. Moreover, hypoxia activated FOXC1 transcription via direct binding of hypoxia-inducible factor-1α (HIF-1α) to the hypoxia-responsi...
Source: Theranostics - September 12, 2017 Category: Molecular Biology Authors: Yu-Jung Lin, Woei-Cherng Shyu, Chi-Wei Chang, Chi-Chung Wang, Chung-Pu Wu, Hsu-Tung Lee, Liang-Jwu Chen, Chia-Hung Hsieh Tags: Research Paper Source Type: research

Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects
Conclusions: Overexpression of MFN2 can be used as a marker to predict the outcome of patients with GC. Furthermore, targeting MFN2 might provide a new therapeutic modality for the treatment of GC.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Chia-Lang Fang, Ding-Ping Sun, Han-Kun Chen, Chih-Chan Lin, Shih-Ting Hung, Yih-Huei Uen, Kai-Yuan Lin Tags: Research Paper Source Type: research

Lipoteichoic acid upregulates plasminogen activator inhibitor ‐1 expression in parapneumonic effusions
ConclusionCulture‐positive PPE, especially that caused by GPB, has a significantly higher level of PAI‐1 than uncomplicated CN PPE. LTA upregulates PAI‐1 expression through activation of TLR2/JNK/activator protein 1 (AP‐1) pathway in human PMC. Better understanding of the modulation of PAI‐1 synthesis by LTA in PPE may provide potential therapies for infected pleural effusions.
Source: Respirology - August 23, 2017 Category: Respiratory Medicine Authors: Kai ‐Ling Lee, Wei‐Lin Chen, Ray‐Jade Chen, Kevin S. Lai, Chi‐Li Chung Tags: Original Article Source Type: research

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.
In this study, we further explored the effects of G2385R on LRRK2 in cells. We found that G2385R LRRK2 has lower steady state intracellular protein levels compared to wild type LRRK2 due to increased protein turnover of the mutant protein. Mechanistically, this is a consequence of a higher affinity of G2385R compared to the wild type protein for two proteins involved in proteasomal degradation, Hsc70 and CHIP. Overexpression of CHIP decreased intracellular protein levels of both G2385R mutant and wild type LRRK2 while siRNA CHIP knock-down had the opposite effect. We suggest that the G2385R substitution tilts the equilibri...
Source: The Biochemical Journal - March 20, 2017 Category: Biochemistry Authors: Rudenko IN, Kaganovich A, Langston RG, Beilina A, Ndukwe K, Kumaran R, Dillman AA, Chia R, Cookson MR Tags: Biochem J Source Type: research

Abstract P4-06-10: Rates of successful engraftment in breast cancer xenograft models based on tissue type: Primary vs relapsed disease
Conclusions: Our data demonstrated that estrogen and ERβ-specific agonists elicit anti-cancer effects in ERβ+ TNBC, both in vitro and in vivo. These effects are partially mediated by cystatins which can interact with, and inhibit, canonical TGFβ signaling, a pathway known to drive TNBC progression. Given the lack of targeted therapies for TNBC patients, the present data suggests that estrogen or ERβ-specific agonists offer a novel approach to manage this subset of patients.Citation Format: den Brok W-l, Chia S, Kalloger S, Bates C, Aparicio S, Mar C, Gelmon K, Eirew P. Rates of successful engraftment in breast cancer x...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: W-l den Brok, S Chia, S Kalloger, C Bates, S Aparicio, C Mar, K Gelmon, P Eirew Tags: Poster Session Abstracts Source Type: research

Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells
In this study, we showed that down-regulating of TS expression in two NSCLC cell lines, human lung adenocarcinoma H1650 and squamous cell carcinoma H1703 cells, with astaxanthin were associated with decreased MKK1/2-ERK1/2 activity. Enforced expression of constitutively active MKK1 (MKK1-CA) vector significantly rescued the decreased TS mRNA and protein levels in astaxanthin-treated NSCLC cells. Combined treatment with a MKK1/2 inhibitor (U0126 or PD98059) further decreased the TS expression in astaxanthin-exposed NSCLC cells. Knockdown of TS using small interfering RNA (siRNA) or inhibiting ERK1/2 activity enhanced the c...
Source: Regulatory Toxicology and Pharmacology - October 1, 2016 Category: Toxicology Source Type: research

Nanoparticle Delivered VEGF-A siRNA Enhances Photodynamic Therapy for Head and Neck Cancer Treatment
h-Chih Hsu
Source: Molecular Therapy - February 8, 2016 Category: Genetics & Stem Cells Authors: Rumwald Leo G LecarosLeaf HuangTsai-Chia LeeYih-Chih Hsu Source Type: research

14-3-3sigma induces heat shock protein 70 expression in hepatocellular carcinoma
Conclusions: Our findings indicate that 14-3-3sigma participates in promoting HCC cell migration and tumor development via beta-catenin/HSF-1alpha/HSP70 pathway regulation. Thus, 14-3-3sigma alone or combined with HSP70 are potential prognostic biomarkers for HCC.
Source: BMC Cancer - June 12, 2014 Category: Cancer & Oncology Authors: Chia-Chia LiuYee-Jee JanBor-Sheng KoYao-Ming WuShu-Man LiangShyh-Chang ChenYen-Ming LeeTzu-An LiuTzu-Ching ChangJohn WangSong-Kun ShyueLi-Ying SungJun-Yang Liou Source Type: research

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