Grouping of chemicals based on the potential mechanisms of hepatotoxicity of naphthalene and structurally similar chemicals using in vitro testing for read-across and its validation
Publication date: Available online 23 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Shota Nakagawa, Maiko Okamoto, Keita Yoshihara, Yuko Nukada, Osamu Morita (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules – a survey of industry 2008-2019
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Timothy K. MacLachlan, Shari Price, Joy Cavagnaro, Laura Andrews, Diann Blanset, Mary Ellen Cosenza, Maggie Dempster, Elizabeth Galbreath, Anna Maria Giusti, Kathleen Marie Heinz-Taheny, Renaud Fleurance, Esther Sutter, Michael W. Leach (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Mercury in Skin-Care Products in India and Consumer Exposure Risks
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Supriti Pramanik, Mukesh Kumar, Asif Qureshi (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Toxicity of boric acid, borax and other boron containing compounds: A review
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Niels Hadrup, Marie Frederiksen, Anoop K. Sharma (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Expanding the toxicologist’s statistical toolbox: using effect size estimation and dose-response modelling for holistic assessments instead of generic testing
Publication date: Available online 22 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Signe M. Jensen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 24, 2021 Category: Toxicology Source Type: research

Human Biomonitoring (HBM)-II values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - description, derivation and discussion
Publication date: Available online 21 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Michael Schümann, Hellmuth Lilienthal, Jürgen Hölzer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 23, 2021 Category: Toxicology Source Type: research

Nonclinical & Clinical Interface - Extrapolation of Nonclinical Data to Support Phase I Clinical Studies
Publication date: Available online 20 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Paul Baldrick, Andreas Reichl (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 20, 2021 Category: Toxicology Source Type: research

Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study.
Publication date: Available online 17 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Michiharu Matsumoto, Shotaro Yamano, Hideki Senoh, Yumi Umeda, Shigeyuki Hirai, Arata Saito, Tatsuya Kasai, Shigetoshi Aiso (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 17, 2021 Category: Toxicology Source Type: research

Draize Human Repeat Insult Patch Test (HRIPT): Seven Decades of Pitfalls and Progress
Publication date: Available online 16 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Jordan L. Bormann, Howard I. Maibach (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 17, 2021 Category: Toxicology Source Type: research

Quantifying Bias in Epidemiologic Studies Evaluating the Association Between Acetaminophen Use and Cancer
Publication date: Available online 15 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Martijn J. Schuemie, Rachel Weinstein, Patrick B. Ryan, Jesse A. Berlin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 16, 2021 Category: Toxicology Source Type: research

Compounded conservatism in European re-entry worker risk assessment of pesticides
Publication date: Available online 12 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Felix M. Kluxen, Edgars Felkers, Jenny Baumann, Neil Morgan, Christiane Wiemann, Franz Stauber, Christian Strupp, Sarah Adham, Christian J. Kuster (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 13, 2021 Category: Toxicology Source Type: research

Increasing Confidence in Waiving Dermal Toxicity Studies: A Comparison of Oral and Dermal Acute Data with Alternative Approaches for Agrochemicals and Products
Publication date: Available online 13 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Sophie van der Kamp, Claire Elliott (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 13, 2021 Category: Toxicology Source Type: research

Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - description, derivation and discussion
Publication date: Available online 12 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Jürgen Hölzer, Hellmuth Lilienthal, Michael Schümann (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 12, 2021 Category: Toxicology Source Type: research

Skin Immune Cell Characterization in Juvenile and Adult Göttingen Minipigs
Publication date: Available online 5 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Linda Allais, Elise Brisebard, Nicolas Ravas, Jean-Paul Briffaux, Marc Pallardy (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 6, 2021 Category: Toxicology Source Type: research

Estimation of toluene exposure in air from bma (s-benzylmercapturic acid) urinary measures using a reverse dosimetry approach based on physiologically pharmacokinetic modeling
Publication date: Available online 3 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Honesty Tohon, Mathieu Valcke, Rocio Aranda-Rodriguez, Andy Nong, Sami Haddad (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 3, 2021 Category: Toxicology Source Type: research

Assessment of the Biochemical Pathways for Acetaminophen Toxicity: Implications for its Carcinogenic Hazard Potential
Publication date: Available online 1 January 2021Source: Regulatory Toxicology and PharmacologyAuthor(s): Hartmut Jaeschke, F. Jay Murray, Andrew D. Monnot, David Jacobson-Kram, Samuel M. Cohen, Jerry F. Hardisty, Evren Atillasoy, Anne Hermanowski-Vosatka, Edwin Kuffner, Daniele Wikoff, Grace A. Chappell, Suren B. Bandara, Milind Deore, Suresh Kumar Pitchaiyan, Gary Eichenbaum (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - January 1, 2021 Category: Toxicology Source Type: research

Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans
Publication date: Available online 31 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Wolfgang Dekant, Paul Jean, Josje Arts (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 31, 2020 Category: Toxicology Source Type: research

The Use of Emerging Safety Biomarkers in Nonclinical and Clinical Safety Assessment – the Current and Future State: An IQ DruSafe Industry Survey
Publication date: Available online 31 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Tanja S. Zabka, John Burkhardt, William J. Reagan, Jean-Charles Gautier, Warren E. Glaab, Magali Guffroy, Joanna Harding, Dominique Brees, Eric McDuffie, Lila Ramaiah, A. Eric Schultze, James D. Smith, Alison Wolfreys, Deidre A. Dalmas (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 31, 2020 Category: Toxicology Source Type: research

Comparative In Vitro Metabolism of Purified Mogrosides Derived from Monk Fruit Extracts
Publication date: Available online 31 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Sachin Bhusari, Chester Rodriguez, Stanley M. Tarka, D. Kwok, George Pugh, Jaspreet Gujral, David Tonucci (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 31, 2020 Category: Toxicology Source Type: research

Incorporating lines of evidence from New Approach Methodologies (NAMs) to reduce uncertainties in a category based read-across: A case study for repeated dose toxicity
Publication date: March 2021Source: Regulatory Toxicology and Pharmacology, Volume 120Author(s): Cynthia B. Pestana, James W. Firman, Mark T.D. Cronin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 31, 2020 Category: Toxicology Source Type: research

Editorial Board
Publication date: February 2021Source: Regulatory Toxicology and Pharmacology, Volume 119Author(s): (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 28, 2020 Category: Toxicology Source Type: research

Testing the Validity of a Proposed Dermal Cancer Slope Factor for Benzo[a]pyrene
Publication date: Available online 25 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Brian H. Magee, Norman D. Forsberg (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 26, 2020 Category: Toxicology Source Type: research

A 13-week subchronic toxicity study of a Dioscorea Rhizome water extract in rats
Publication date: Available online 21 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Seung-Beom Cha, Hak-Soo Kim, Jin-Sook Bae, Si-Whan Song, Je-Oh Lim, Jong-Choon Kim (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 22, 2020 Category: Toxicology Source Type: research

Non-Dioxin-Like Polychlorinated Biphenyl Neurotoxic Equivalents Found in Environmental and Human Samples
Publication date: Available online 17 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): E.B. Holland, I.N. Pessah (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 18, 2020 Category: Toxicology Source Type: research

A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling
Publication date: Available online 17 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Joel Bercu, Melisa J. Masuda‐Herrera, Alejandra Trejo-Martin, Catrin Hasselgren, Jean Lord, Jessica Graham, Matthew Schmitz, Lawrence Milchak, Colin Owens, Surya Hari Lal, Richard Marchese Robinson, Sarah Whalley, Phillip Bellion, Anna Vuorinen, Kamila Gromek, William A. Hawkins, Iris Van de Gevel, Kathleen Vriens, Raymond Kemper, Russell Naven (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 18, 2020 Category: Toxicology Source Type: research

Evidence-based regulations for bioinformatic prediction of allergen cross-reactivity are needed
Publication date: Available online 15 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Rod A. Herman, Ping Song, Henry P. Mirsky, Jason M. Roper (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 15, 2020 Category: Toxicology Source Type: research

Reproductive and developmental toxicity screening study of an acetone extract of rosemary
Publication date: Available online 13 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Kirt R. Phipps, Barbara Danielewska-Nikiel, Jessica Mushonganono, Nigel Baldwin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 14, 2020 Category: Toxicology Source Type: research

Risk Assessment of Predicted Serum Concentrations of Bisphenol A in Children and Adults Following Treatment with Dental Composite Restoratives, Dental Sealants, or Orthodontic Adhesives using Physiologically Based Pharmacokinetic Modeling
Publication date: Available online 7 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Bradford D. Bagley, Jordan N. Smith, Justin G. Teeguarden (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 7, 2020 Category: Toxicology Source Type: research

A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure.
Publication date: Available online 7 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): David J. Kirkland, Meredith L. Sheil, Michael A. Streicker, George E. Johnson (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 7, 2020 Category: Toxicology Source Type: research

A review to support the derivation of a worst-case dermal penetration value for nanoparticles
Publication date: February 2021Source: Regulatory Toxicology and Pharmacology, Volume 119Author(s): Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 4, 2020 Category: Toxicology Source Type: research

Subchronic toxicity study in rats evaluating herbicide-tolerant soybean DAS-68416-4
Publication date: Available online 28 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Li Zhang, Shu-Fei Li, Qing-Hong Zhou, Ying-Hua Liu, Jing Zhang, Zhi-Yong Qian (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

A call for action on the development and implementation of new methodologies for safety assessment of chemical-based products in the EU – A short communication
Publication date: Available online 26 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Derek J. Knight, Hubert Deluyker, Qasim Chaudhry, Jean-Marc Vidal, Alie de Boer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

A review to support the derivation of a worst-case dermal penetration value for nanoparticles.
Publication date: Available online 26 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

Evaluating chemical similarity as a measure to identify potential substances of very high concern
Publication date: Available online 20 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Pim N.H. Wassenaar, Emiel Rorije, Martina G. Vijver, Willie J.G.M. Peijnenburg (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 21, 2020 Category: Toxicology Source Type: research

Aloe gel-base food products: Chemical, toxicological, and regulatory aspects
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Alessandra Baldi, Eduardo Sommella, Pietro Campiglia, Maria Daglia (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Antimony release from polyester textiles by artificial sweat solutions: A call for a standardized procedure
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Marc Biver, Andrew Turner, Montserrat Filella (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Kirt R. Phipps, Dayna Lozon, Nigel Baldwin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Simple methodology for ensuring the precision of measuring radioactivity at low concentrations in very small tissues using quantitative whole-body autoradiography
Publication date: Available online 20 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Takanori Hironaka, Kazuhiro Inazawa, Yukari Tanaka, Hiroshi Hasegawa (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Editorial Board
Publication date: December 2020Source: Regulatory Toxicology and Pharmacology, Volume 118Author(s): (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Timothy K. MacLachlan, Sven Kronenberg, Nikki Marshall, Laura Andrews, Shawn Jay Berens, Frederic Brouta, Birgit Fogal, Wendy Freebern, Danuta Herzyk, Cris Kamperschroer, Andrea Kiessling, Marlowe Schneidkraut, Curtis Maier (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 19, 2020 Category: Toxicology Source Type: research

Safety assessment of ethanolic root extract of Zaleya decandra (EEZD) in Wistar rats
Publication date: Available online 17 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Malarvizhi Deivasigamani, Nagaraj Kannan, Nishu Sekar, Hariprasath Lakshmanan (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 18, 2020 Category: Toxicology Source Type: research

Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride Co-formulation against VX in a Guinea pig model
Publication date: Available online 16 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jiska Kentrop, Vladimir Savransky, Steven D. Klaassen, Tomas van Groningen, Sara Bohnert, Alex S. Cornelissen, Laura Cochrane, John Barry, Marloes J.A. Joosen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 17, 2020 Category: Toxicology Source Type: research

A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane
Publication date: Available online 12 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Mark Lafranconi, Robert Budinsky, Lisa Corey, Joanna Klapacz, James Crissman, Matthew LeBaron, Rachel Golden, Richard Pleus (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 14, 2020 Category: Toxicology Source Type: research

Evaluation of dietary dose administration as an alternative to oral gavage in the rodent uterotrophic and Hershberger assays
Publication date: Available online 9 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Lauren Markell, John C. O'Connor, Ruijuan Luo, Joseph Klems, Brian Sayers, Robert Mingoia (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 10, 2020 Category: Toxicology Source Type: research

The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses
Publication date: Available online 10 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Ian Kimber (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 10, 2020 Category: Toxicology Source Type: research

The performance, reliability and potential application of in silico models for predicting the acute oral toxicity of pharmaceutical compounds
Publication date: Available online 6 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jessica Graham, Maryann Rodas, Jedd Hillegass, Gene Schulze (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 7, 2020 Category: Toxicology Source Type: research

Assessment of the potential allergenicity and toxicity of Pichia proteins in a novel leghemoglobin preparation
Publication date: Available online 7 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Teresa F. Reyes, Yiming Chen, Rachel Z. Fraser, Teresa Chan, Xin Li (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 7, 2020 Category: Toxicology Source Type: research

Computational identification of preservatives with potential neuronal cytotoxicity
Publication date: Available online 4 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Hung-Lin Kan, Chia-Chi Wang, Ying-Chi Lin, Chun-Wei Tung (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 6, 2020 Category: Toxicology Source Type: research

Corrigendum to “28-day somatic gene mutation study of 1-Bromopropane in female big blue® B6C3F1 Mice via whole-Body inhalation: Support for a carcinogenic threshold” [Regul. Toxicol. Pharmacol., 104 (2019) 1–7]
Publication date: Available online 3 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Mark Stelljes, Robert Young, Jeff Weinberg (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 4, 2020 Category: Toxicology Source Type: research

Considerations for setting occupational exposure limits for novel pharmaceutical modalities
Publication date: Available online 2 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jessica Graham, Jedd Hillegass, Gene Schulze (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 3, 2020 Category: Toxicology Source Type: research