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Drug: Eloxatin

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Total 66 results found since Jan 2013.

microRNA ‐29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon cancer by targeting FOLR1
AbstractThe present study was aimed to explore the functional role of microRNA (miR) ‐29b in colon cancer, as well as underlying mechanisms. Expressions of miR‐29b and folate receptor 1 (FOLR1) were measured in both human colon tumor samples and cell lines. Colon cancer cell lines SW480 and SW620 were transfected with miR‐29b mimic, antisense oligonucleotides (ASO)‐miR‐29b , small interfering (siRNA) against FOLR1 (si‐FOLR1), or corresponding negative controls (NCs), and then were incubated with or without oxaliplatin (L‐OHP). Thereafter, cell viability, cytotoxicity, cell apoptosis, and expression of FOLR1, ...
Source: BioFactors - October 16, 2019 Category: Biochemistry Authors: Qiang Fu, Jindai Zhang, Gaofeng Huang, Yonglei Zhang, Minghai Zhao, Yongchao Zhang, Jianguo Xie Tags: RESEARCH COMMUNICATION Source Type: research

Cancers, Vol. 11, Pages 1330: Transport-Mediated Oxaliplatin Resistance Associated with Endogenous Overexpression of MRP2 in Caco-2 and PANC-1 Cells
In conclusion, oxaliplatin is a substrate of MRP2 with possibly two binding sites, and silencing MRP2 increased oxaliplatin accumulation and cytotoxicity in two widely available gastrointestinal tumour lines (PANC-1 and Caco-2).
Source: Cancers - September 7, 2019 Category: Cancer & Oncology Authors: Riya Biswas Piyush Bugde Ji He Fabrice Merien Jun Lu Dong-Xu Liu Khine Myint Johnson Liu Mark McKeage Yan Li Tags: Article Source Type: research

Keratin 6, induced by chronic cisplatin exposure, confers chemoresistance in human gastric carcinoma cells.
Authors: Lim SC, Parajuli KR, Han SI Abstract Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin (SNU601‑cis2 and SNU601‑cis10), but not in the parental SNU601 cells as confirmed by quantitative PCR, immunoblotting, and immunofluorescence assays. K6 is a type II keratin and is known to form a keratin filament in conjugation with type I keratin, K1...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Overexpression of CASC11 in ovarian squamous cell carcinoma mediates the development of cancer cell resistance to chemotherapy.
Abstract LncRNA CASC11 promotes gastric cancer and colon cancer. Our study analyzed the role of CASC11 in ovarian squamous cell carcinoma (OSCC). In the present study we showed that plasma CASC11 was upregulated in OSCC, and the upregulation of CASC11 distinguished OSCC patients from control group. Plasma levels of CASC11 were further increased after chemotherapy. Treatment with oxaliplatin, tetraplatin, cisplatin, and carboplatin mediated the upregulation of CASC11 in cells of OSCC cell line. In addition, overexpression of CASC11 led to increased cancer cell viability under oxaliplatin, tetraplatin, cisplatin, an...
Source: Gene - June 6, 2019 Category: Genetics & Stem Cells Authors: Shen F, Feng L, Zhou J, Zhang H, Xu Y, Jiang R, Zhang H, Chen Y Tags: Gene Source Type: research

GSE113242 Dysfunction of circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulation of Aldh3a1 gene
In this study, we identified up-regulation of Aldehyde dehydrogenase 3a1 (Aldh3a1) gene in oncogenic transformed mouse embryo fibroblasts prepared from Per2-mutant (Per2m/m) mice, which were associated with the resistance against chemotherapeutic drugs. Co-expression of H-rasV12 and SV40 large T antigen induced malignant transformation of both wild-type and Per2m/m cells, but the cytotoxic effects of methotrexate, gemcitabine, etoposide, vincristine, and oxaliplatin were significantly alleviated in oncogenic transformed Per2m/m cells. Although introduction of oncogenes increased the expression of Aldh3a1 in both wild-type ...
Source: GEO: Gene Expression Omnibus - October 10, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer
This study outlines the regulatory effects of oxaliplatin on miRNAs expression in colon cancer cells and correlates it with the changing microRNA expression with p53 and p73 expression status in cells. HCT116p53+/+ and HCT116p53-/- cells were exposed to oxaliplatin, and the cellular viability was determined by XTT. p73 was knocked down using siRNA and the tumor cells were then treated with oxaliplatin. The expression profile of 384 miRNAs was determined by TaqMan® human miRNA array and calculated by the ∆∆Ct method. Cellular viability was found to decrease after the treatment with oxaliplatin in a dose-dep...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jasmine Evert, Surajit Pathak, Xiao-Feng Sun, Hong Zhang Tags: Research Paper Source Type: research

TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells.
Abstract TRIB3, which is a pseudokinase known to regulate multiple pro-survival pathways, appears to be a potential therapeutic target for the treatment of human tumors. However, its precise role in cancer is controversial, as TRIB3 protein levels have been associated with both good and poor prognosis in cancer patients. Here, we investigated the significance of TRIB3 expression in the survival of gastric cancer cells exposed to anticancer drugs. We found that the tested anticancer drug, doxorubicin, induced cytotoxicity by decreasing TRIB3 transcription, which was followed by apoptotic cell death. Moreover, TRIB3...
Source: Archives of Biochemistry and Biophysics - April 22, 2017 Category: Biochemistry Authors: Wu IJ, Lin RJ, Wang HC, Yuan TM, Chuang SM Tags: Arch Biochem Biophys Source Type: research

MicroRNA-137 chemosensitizes colon cancer cells to the chemotherapeutic drug oxaliplatin (OXA) by targeting YBX1.
In this study, we utilized microRNA microarray analysis and real-time PCR to verify that miR-93, miR-191, miR-137, miR-181 and miR-491-3p were significantly down-regulated and that miR-96, miR-21, miR-22, miR-15b and miR-92 were up-regulated in both HCT-15/OXA and SW480/OXA cell lines. Blocking miR-137 caused a significant inhibition of OXA-induced cytotoxicity, therefore, miR-137 was chosen for further research. An in vitro cell viability assay showed that knockdown of miR-137 in HCT-15 and SW480 cells caused a marked inhibition of OXA-induced cytotoxicity. Moreover, we found that miR-137 was involved in repression of YBX...
Source: Cancer Biomarkers - January 1, 2017 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells.
CONCLUSION: siRNA-mediated down-regulation of livin gene expression could significantly suppress colon cancer growth and enhance the cytotoxic effects of anticancer drugs such as 5-FU and L-OHP. The results of this study suggest that silencing livin gene expression in combination with treatment with anticancer drugs might be a novel cancer therapy for colorectal cancer. PMID: 27904848 [PubMed - in process]
Source: Annals of Surgical Treatment and Research - December 3, 2016 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

GSE83129 RNA profiling in metastatic colorectal cancer patients treated first-line with oxaliplatin
Contributors : Mads H Rasmussen ; Iben Lyskjær ; Claus L AndersenSeries Type : Expression profiling by arrayOrganism : Homo sapiensOxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Here, we have used in vitro models to show that miR-625-3p functionally induces oxPt resistance in CRC cells, and have identified signalling networks affected by miR-625-3p. The p38 MAPK activator MAP2K6 was shown to be a direct target of miR-625-3p, and, accordingly, was downregulated in patients n...
Source: GEO: Gene Expression Omnibus - June 9, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Effects of taxol resistance gene 1 expression on the chemosensitivity of SGC-7901 cells to oxaliplatin.
Authors: Liu L, Bai Z, Ma X, Wang T, Yang Y, Zhang Z Abstract The present study aimed to evaluate the role of taxol resistance gene 1 (Txr1) in the development of oxaliplatin (L-OHP) resistance in gastric cancer (GC). Using SGC-7901 cells as a model, Txr1 was exogenously expressed or knocked down using small interfering RNA. Quantitative polymerase chain reaction (qPCR) and western blotting were performed to establish whether the Txr1 gene is involved in chemoresistance, and cell proliferation was assessed using an MTS assay. To this end, the mRNA and protein levels of Txr1, thrombospondin-1 and excision repair cro...
Source: Experimental and Therapeutic Medicine - March 23, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Cardiac Glycoside-induced Cell Death and Rho/Rho Kinase Pathway: Implication of Different Regulation in Cancer Cell Lines
In conclusion, these findings indicate that the Rho/ROCK pathway is regulated differently in cancer cell lines compared to normal cells during cardiac glycosides-induced cell death.
Source: Steroids - March 22, 2016 Category: Drugs & Pharmacology Source Type: research

Enhancement of Drug Sensitivity by Knockdown of HIF-1α in Gastric Carcinoma Cells.
In this study, the effects of hypoxia-inducible factor-1α (HIF-1α) on gastric carcinoma (GC) drug resistance through apoptosis-related genes are investigated. First, HIF-1α-specific siRNA was synthetized and transfected into drug-resistant GC cell line OCUM-2MD3/L-OHP. Then MTT assay was applied to test the inhibition rate of GC cells by 5-fluorouracil (5-FU) and oxaliplatin (L-OHP). After that, flow cytometry (FCM) was applied to measure apoptosis rate. qPCR and Western blot assay were employed to detect HIF-1α and apoptosis-related genes. Results showed that HIF-1α in OCUM-2MD3/L-OHP cells was higher than that in OC...
Source: Oncology Research - March 6, 2016 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Downregulation of SMC1A inhibits growth and increases apoptosis and chemosensitivity of colorectal cancer cells
Conclusions The findings of this study suggest that SMC1A plays an oncogenic role in colorectal cancer and that it might be a promising target for colorectal cancer therapy.
Source: Journal of International Medical Research - February 17, 2016 Category: Research Authors: Li, J., Feng, W., Chen, L., He, J. Tags: Research Reports Source Type: research