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Total 1410 results found since Jan 2013.
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3
Autophagy. 2022 Mar 1:1-17. doi: 10.1080/15548627.2022.2029671. Online ahead of print.ABSTRACTTFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) orchestrate the cellular response to a variety of stressors, including nutrient deprivation, oxidative stress and pathogens. Here we describe a novel interaction of TFEB and TFE3 with the FAcilitates Chromatin Transcription (FACT) complex, a heterodimeric histone chaperone consisting of SSRP1 and SUPT16H that mediates nucleosome disassembly and assembly, thus facilitating transcription. Extracellular stimuli, such as nutrient deprivation or o...
Source: Autophagy - March 1, 2022 Category: Cytology Authors: Eutteum Jeong Jos é A Martina Pablo S Contreras Juhyung Lee Rosa Puertollano Source Type: research
Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis
In this study, we worked toward researching the effects and mechanisms of a farnesyltransferase (FTase) inhibitor Lonafarnib (Lon) on receptor activator of nuclear factor κB (NF-κB) ligand (RANKL)-induced osteoclastogenesis and bone resorption, as well as the impacts of Lon on titanium particle-induced osteolysis. To investigate the impacts of Lon on bone resorption and osteoclastogenesis in vitro, bone marrow macrophages were incubated and stimulated with RANKL and macrophage colony-stimulating factor (M-CSF). The influence of Lon on osteolysis prevention in vivo was examined utilizing a titanium particle-induced mouse ...
Source: Frontiers in Pharmacology - March 1, 2022 Category: Drugs & Pharmacology Source Type: research
Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF- κB/HPSE1 Signaling Pathway During Inflammation
Front Pharmacol. 2022 Jan 3;12:791841. doi: 10.3389/fphar.2021.791841. eCollection 2021.ABSTRACTTetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive. Vascular glycocalyx coating on the endothelium would be damaged and caused endothelial dysfunction in the inflammatory microenvironment, which was the initial factor of morbidity of many vascular diseases, such as atherosclerosis (AS). Here, we thoroughly investigated the molecular mechanism of TMP on vascular endot...
Source: Atherosclerosis - February 21, 2022 Category: Cardiology Authors: Jin Lei Peng Xiang Shengmei Zeng Le Chen Lei Zhang Zhiyi Yuan Jun Zhang Tingting Wang Ruihong Yu Wanping Zhang Issa Issoufou Ibrahim Limei Ma Chao Yu Source Type: research
Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis
Biochem Biophys Res Commun. 2022 Feb 12;600:44-50. doi: 10.1016/j.bbrc.2022.02.018. Online ahead of print.ABSTRACTThe heat shock transcription factor HSF1 regulates the inducible Hsp gene transcription, whereas HSF2 is involved in the constitutive transcription. HSFs can work for the non-heat shock genes transcription in a case-specific manner to facilitate normal cellular functions. Here, we demonstrate that HSF2 acts as an upstream regulator of heat shock-induced autophagy response in a rat histiocytoma. The heat-induced HSF2 transactivates the B-cell translocation gene-2 (BTG2) transcription, and the latter acts as a tr...
Source: Cell Research - February 19, 2022 Category: Cytology Authors: Abhijnya Kanugovi Vijayavittal Pankaj Kumar Sreedevi Sugunan Chitra Joseph Bharath Devaki Khanderao Paithankar Sreedhar Amere Subbarao Source Type: research
Twinfilin-1 is an essential regulator of myogenic differentiation through the modulation of YAP in C2C12 myoblasts
In this study, we unveiled the roles played by TWF1 in the proliferation and differentiation of C2C12 myoblasts. TWF1 was the predominant isoform in myoblasts, and its expression was induced during the early stage of differentiation. Knockdown of TWF1 by siRNA (siTWF1) induced the accumulation of actin filaments (F-actin) and promoted the nuclear translocation of Yes-associated protein (YAP) in the Hippo signaling pathway. TWF1 depletion activated transcription of YAP target genes and induced cell cycle and proliferation in myoblasts. Furthermore, TWF1 knockdown markedly reduced the expressions of myogenic regulatory facto...
Source: Biochemical and Biophysical Research communications - February 15, 2022 Category: Biochemistry Authors: Mai Thi Nguyen You Han Won Tae Won Kwon Wan Lee Source Type: research
Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis
In this study, we investigated whether this atypical BMP canonical signaling is conserved in human odontogenesis. We showed that pSMAD1/5/8 is required for the expression of Msh homeobox 1 (MSX1), a well-defined BMP signaling target gene, in human dental mesenchyme, but the typical BMP canonical signaling is in fact not operating in the early human developing tooth, as evidenced by the absence of pSMAD1/5/8-SMAD4 complexes in the dental mesenchyme and translocation of pSMAD1/5/8, and the expression of MSX1 induced by BMP4 is mothers against decapentaplegic homolog 4 (SMAD4)-independent in human dental mesenchymal cells. Mo...
Source: Frontiers in Physiology - February 8, 2022 Category: Physiology Source Type: research
Fibroblast activation protein-alpha knockdown suppresses prostate cancer cell invasion and proliferation
CONCLUSIONS: In conclusion, down-regulation of FAP-α can inhibit the invasion and proliferation of prostate cancer. Our study provides a theoretical basis for the targeted treatment of prostate cancer.PMID:35129203 | DOI:10.14670/HH-18-430
Source: Histology and Histopathology - February 7, 2022 Category: Cytology Authors: Jiali An Dingkun Hou Lei Wang Lili Wang Yuanyuan Yang Haitao Wang Source Type: research
IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells
CONCLUSION: Inhibition of IGF-1 R/YAP signal pathway is involved in collagen V-induced insulin biosynthesis and secretion in INS-1 cells.PMID:35129018 | DOI:10.1080/03008207.2021.2025225
Source: Connective Tissue Research - February 7, 2022 Category: Research Authors: Yingying Zhu Shuaigao Chen Weiwei Liu Fanxing Xu Jingyu Lu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
IKK α plays a major role in canonical NF-kB signalling in colorectal cells
Biochem J. 2022 Jan 14:BCJ20210783. doi: 10.1042/BCJ20210783. Online ahead of print.ABSTRACTInhibitor of kappa B (IκB) kinase β (IKKβ) has long been viewed as the dominant IKK in the canonical nuclear factor-κB (NF-κB) signalling pathway, with IKKα being more important in non-canonical NF-κB activation. Here we have investigated the role of IKKα and IKKβ in canonical NF-κB activation in colorectal cells using CRISPR-Cas9 knock-out cell lines, siRNA and selective IKKβ inhibitors. IKKα and IKKβ were redundant for IκBα phosphorylation and turnover since loss of IKKα or IKKβ alone had little (SW620 cells) or n...
Source: The Biochemical Journal - January 14, 2022 Category: Biochemistry Authors: Jack A Prescott Kathryn Balmanno Jennifer P Mitchell Hanneke Okkenhaug Simon J Cook Source Type: research
