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Total 1410 results found since Jan 2013.
Long non-coding RNA PVT1 promotes the proliferation, migration and EMT process of ovarian cancer cells by regulating CTGF
In conclusion, lncRNA PVT1 promotes the proliferation, migration, invasiveness and EMT process of ovarian cancer cells, and CTGF contributes to the effect of lncRNA PVT1.PMID:36688109 | PMC:PMC9843302 | DOI:10.3892/ol.2022.13657
Source: Oncology Letters - January 23, 2023 Category: Cancer & Oncology Authors: Lingling Dong Huan Wang Yun Gao Shuai Wang Weibo Wang Source Type: research
Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
J Bioenerg Biomembr. 2022 Dec 23. doi: 10.1007/s10863-022-09954-3. Online ahead of print.ABSTRACTMyocardial ischemia-reperfusion (I/R) injury is a major cause of poor hemodynamic reconstitution outcomes after myocardial infarction or circulatory arrest. Currently, the search for effective therapeutic agents and tools is a focus of research in the field of myocardial I/R injury. Resveratrol (Res) has been extensively studied in recent years because of its good cardiovascular therapeutic effects, but its specific mechanism of action has not been fully elucidated. Therefore, the aim of this study was to investigate the mechan...
Source: Cell Research - December 23, 2022 Category: Cytology Authors: Hao Tian Yonghong Xiong Zhongyuan Xia Source Type: research
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
In this study, we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and ferroptosis. We established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced ICH. WFA was injected intracerebroventricularly at 0.1, 1 or 5 µg/kg once daily for 7 days, starting immediately after ICH operation. WFA markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral hemorrhage. Through in vitro experiments,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Zi-Xian Zhou Qi Cui Ying-Mei Zhang Jia-Xin Yang Wen-Jing Xiang Ning Tian Yan-Lin Jiang Mei-Ling Chen Bin Yang Qing-Hua Li Ru-Jia Liao Source Type: research
