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Total 1410 results found since Jan 2013.
Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes
Endocr J. 2022 Mar 23. doi: 10.1507/endocrj.EJ21-0392. Online ahead of print.ABSTRACTSelenoprotein P is upregulated in type 2 diabetes, causing insulin and exercise resistance. We have previously reported that eicosapentaenoic acid (EPA) negatively regulates Selenop expression by suppressing Srebf1 in H4IIEC3 hepatocytes. However, EPA downregulated Srebf1 long before downregulating Selenop. Here, we report additional novel mechanisms for the Selenop gene regulation by EPA. EPA upregulated Foxo1 mRNA expression, which was canceled with the ERK1/2 inhibitor, but not with the PKA inhibitor. Foxo1 knockdown by siRNA initiated ...
Source: Endocrine Journal - March 24, 2022 Category: Endocrinology Authors: Kyoko Kamoshita Natsumi Tajima-Shirasaki Kiyo-Aki Ishii Takayoshi Shirasaki Hiroaki Takayama Halimulati Abuduwaili Tuerdiguli Abuduyimiti Hein Ko Oo Xingyu Yao Qifang Li Cynthia M Galicia-Medina Shuichi Kaneko Toshinari Takamura Source Type: research
Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor
Sci Rep. 2022 Mar 23;12(1):5052. doi: 10.1038/s41598-022-07955-1.ABSTRACTLysosomal biogenesis plays a vital role in cell fate. Under certain conditions, excessive lysosomal biogenesis leads to susceptibility for lysosomal membrane permeabilization resulting in various pathological conditions including cell death. In cancer cells apoptosis machinery becomes dysregulated during the course of treatment, thus allows cancer cells to escape apoptosis. So it is therefore imperative to identify cytotoxic agents that exploit non-apoptotic mechanisms of cell death. Our study showed that pancreatic cancer cells treated with SDS-203 t...
Source: Cell Research - March 24, 2022 Category: Cytology Authors: Sameer Ullah Khan Anup Singh Pathania Abubakar Wani Kaneez Fatima Mubashir Javed Mintoo Baseerat Hamza Masroor Ahmad Paddar Wadhwa Bhumika Loveleena Kour Anand Mir Shahid Maqbool Sameer Ahmad Mir Jaspreet Kour Vunnam Venkateswarlu Dilip Manikrao Mondhe Sa Source Type: research
Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes
Endocr J. 2022 Mar 23. doi: 10.1507/endocrj.EJ21-0392. Online ahead of print.ABSTRACTSelenoprotein P is upregulated in type 2 diabetes, causing insulin and exercise resistance. We have previously reported that eicosapentaenoic acid (EPA) negatively regulates Selenop expression by suppressing Srebf1 in H4IIEC3 hepatocytes. However, EPA downregulated Srebf1 long before downregulating Selenop. Here, we report additional novel mechanisms for the Selenop gene regulation by EPA. EPA upregulated Foxo1 mRNA expression, which was canceled with the ERK1/2 inhibitor, but not with the PKA inhibitor. Foxo1 knockdown by siRNA initiated ...
Source: Endocrine Journal - March 24, 2022 Category: Endocrinology Authors: Kyoko Kamoshita Natsumi Tajima-Shirasaki Kiyo-Aki Ishii Takayoshi Shirasaki Hiroaki Takayama Halimulati Abuduwaili Tuerdiguli Abuduyimiti Hein Ko Oo Xingyu Yao Qifang Li Cynthia M Galicia-Medina Shuichi Kaneko Toshinari Takamura Source Type: research
Molecules, Vol. 27, Pages 1990: Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway
In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endothelial cell injury and atherosclerosis in apoE-/- mice. Our results showedthat both dihydrohomoplantagin and homoplantaginin inhibited apoptosis and the increased level of ICAM-1 and VCAM-1 in oxLDL-stimulated HUVECs and the plaque endothelium of apoE-/- mice. Additionally, both of them restricted atherosclerosis development of apoE-/- mice. Mechanistic studies showed that oxLDL-induced the increase in ROS production, phosphorylation of ERK and nuclear translocation of NF-κB in HUVECs was si...
Source: Molecules - March 19, 2022 Category: Chemistry Authors: Ning Meng Kai Chen Yanhong Wang Jiarong Hou Wenhui Chu Shan Xie Fengying Yang Chunhui Sun Tags: Article Source Type: research
< em > Chelidonium majus < /em > Induces Apoptosis of Human Ovarian Cancer Cells Via ATF3-Mediated Regulation of Foxo3a by Tip60
This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of B...
Source: Journal of Microbiology and Biotechnology - March 14, 2022 Category: Biotechnology Authors: Lei Shen Soon Lee Jong Cheon Joo Eunmi Hong Zhen Yang Cui Eunbi Jo Soo Jung Park Hyun-Jin Jang Source Type: research
