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Total 1410 results found since Jan 2013.
Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Brain Research - July 25, 2022 Category: Neurology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research
Network Pharmacology-Based Strategy to Investigate the Mechanisms of < em > Cibotium barometz < /em > in Treating Osteoarthritis
Evid Based Complement Alternat Med. 2022 Jul 14;2022:1826299. doi: 10.1155/2022/1826299. eCollection 2022.ABSTRACTCibotium barometz is a representative tonifying kidney drug and is widely used for osteoarthritis (OA) in traditional Chinese medicine. However, its regulatory mechanisms in treating OA remain to be sufficiently investigated. The main chemical components of Cibotium barometz were screened through the TCMID database and the corresponding targets were acquired through SwissTargetPrediction. The OA-related targets were obtained from the OMIM, Genecards, Genebank, TTD, and DisGeNET databases. The prediction of key ...
Source: Evidence-based Complementary and Alternative Medicine - July 25, 2022 Category: Complementary Medicine Authors: Guang-Yao Chen Yi-Fei Wang Xin-Bo Yu Xiao-Yu Liu Jia-Qi Chen Jing Luo Qing-Wen Tao Source Type: research
Storax Protected Primary Cortical Neurons from Oxygen-Glucose Deprivation/Reoxygenation Injury via Inhibiting the TLR4/TRAF6/NF- κB Signaling Pathway
This study aimed to elucidate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The cortical neurons of Wistar rats were primarily cultured in vitro. TheTUNELmethod and CM-H2DCFDA probe were used to detect cell apoptosis and reactive oxygen species (ROS) expression. Enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, and Western blot were used to detect the expression of inflammatory cytokines and proteins of the TLR4/TRAF6/NF-κB signaling pathway. Immunofluorescence was used to measure NF-κB nuc...
Source: Cell Research - July 25, 2022 Category: Cytology Authors: Lin Li Shaoqian Yue Rui Han Yajun Yu Peng Zhang Ling Lv Jinqiang Zhu Min Zhou Xiang Fan Han Zhang Source Type: research
Network Pharmacology-Based Strategy to Investigate the Mechanisms of < em > Cibotium barometz < /em > in Treating Osteoarthritis
Evid Based Complement Alternat Med. 2022 Jul 14;2022:1826299. doi: 10.1155/2022/1826299. eCollection 2022.ABSTRACTCibotium barometz is a representative tonifying kidney drug and is widely used for osteoarthritis (OA) in traditional Chinese medicine. However, its regulatory mechanisms in treating OA remain to be sufficiently investigated. The main chemical components of Cibotium barometz were screened through the TCMID database and the corresponding targets were acquired through SwissTargetPrediction. The OA-related targets were obtained from the OMIM, Genecards, Genebank, TTD, and DisGeNET databases. The prediction of key ...
Source: Evidence-based Complementary and Alternative Medicine - July 25, 2022 Category: Complementary Medicine Authors: Guang-Yao Chen Yi-Fei Wang Xin-Bo Yu Xiao-Yu Liu Jia-Qi Chen Jing Luo Qing-Wen Tao Source Type: research
Targeting HER3-dependent activation of nuclear AKT improves radiotherapy of non-small celllung cancer
CONCLUSION: IR-induced activation of nuclear AKT occurs inside the nucleus that is mainly dependent on HER3 expression in NSCLC. These findings suggest that targeting HER3 in combination with radiotherapy may provide a logical treatment option for investigation in selected NSCLC patients.PMID:35839938 | DOI:10.1016/j.radonc.2022.07.008
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2022 Category: Radiology Authors: Mahmoud Toulany Mari Iida Konstanze Lettau John P Coan Simone Rebholz Shayan Khozooei Paul M Harari Deric L Wheeler Source Type: research
Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import
In human cells, approximately 30% of all polypeptides enter the secretory pathway at the level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal signal peptides (SPs) or more or less amino-terminal transmembrane helices (TMHs), which serve as targeting determinants, at the level of the precursor polypeptides and a multitude of cytosolic and ER proteins, which facilitate their ER import. Alone or in combination SPs and TMHs guarantee the initial ER targeting as well as the subsequent membrane integration or translocation. Cytosolic SRP and SR, its receptor in the ER membrane, mediate cotransl...
Source: Frontiers in Physiology - July 11, 2022 Category: Physiology Source Type: research
Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research
A novel synthetic peptide SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of Parkinson's disease
This study was conducted to explore the protective effects of SVHRSP, a synthetic heat-resistant peptide derived from scorpion venom, against dopaminergic neurodegeneration in experimental models of PD. Results showed that SVHRSP dose-dependently reduced the loss of dopaminergic neuron in the nigrostriatal pathway and motor impairments in both rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced mouse PD models. Microglial activation and imbalance of M1/M2 polarization were also abrogated by SVHRSP in both models. In rotenone-treated primary midbrain neuron-glial cultures, loss of dopaminer...
Source: Free Radical Biology and Medicine - June 27, 2022 Category: Biology Authors: Xiaomeng Zhang Dezhen Tu Sheng Li Na Li Donglai Li Yun Gao Lu Tian Jianing Liu Xuan Zhang Jau-Shyong Hong Liyan Hou Jie Zhao Qingshan Wang Source Type: research
Persistent Escherichia coli infection in renal tubular cells enhances calcium oxalate crystal-cell adhesion by inducing ezrin translocation to apical membranes via Rho/ROCK pathway
In this study, Escherichia coli, the most common bacterium found in recurrent UTI was used to establish the in vitro model for persistent infection of renal epithelial cells. The promoting effects of persistent E. coli infection on kidney stone formation were validated by COM crystal-cell adhesion assay, followed by immunofluorescence study for changes in surface expression of the known COM crystal receptors. Among the five receptors examined, only ezrin had significantly increased level on the surface of persistently infected cells without change in its total level. Such translocation of ezrin to apical membranes was conf...
Source: Cellular and Molecular Life Sciences : CMLS - June 24, 2022 Category: Cytology Authors: Rattiyaporn Kanlaya Visith Thongboonkerd Source Type: research
