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Total 1410 results found since Jan 2013.
Targeting Pro-Survival Autophagy Enhanced GSK-3 β Inhibition-Induced Apoptosis and Retarded Proliferation in Bladder Cancer Cells
Curr Oncol. 2023 May 28;30(6):5350-5365. doi: 10.3390/curroncol30060406.ABSTRACTAdvanced bladder cancer (BC) (local invasive and/or metastatic) is not curable even with cytotoxic chemotherapy, immune checkpoint inhibitors, and targeted treatment. Targeting GSK-3β is a promising novel approach in advanced BC. The induction of autophagy is a mechanism of secondary resistance to various anticancer treatments. Our objectives are to investigate the synergistic effects of GSK-3β in combination with autophagy inhibitors to evade GSK-3β drug resistance. Small molecule GSK-3β inhibitors and GSK-3β knockdown using siRNA promote...
Source: Current Oncology - June 27, 2023 Category: Cancer & Oncology Authors: Yuko Shirono Vladimir Bilim Tsutomu Anraku Hiroo Kuroki Akira Kazama Masaki Murata Kaede Hiruma Yoshihiko Tomita Source Type: research
Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells
This study is the first to demonstrate that curcumin can prevent oxidative stress-induced auditory hair cell degeneration through Nrf2 activation, highlighting its potential therapeutic value in preventing ARHL.PMID:37334787 | DOI:10.1016/j.bcp.2023.115575
Source: Biochemical Pharmacology - June 19, 2023 Category: Drugs & Pharmacology Authors: Ning Li Xirui Yan Weiling Huang Min Chu Yang Dong Haiyan Song Yinting Peng Jianrong Shi Qing Liu Source Type: research
