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Total 1410 results found since Jan 2013.
AMP-activated protein kinase-dependent nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in senescent human diploid fibroblasts
Aging (Albany NY). 2022 Jan 12;14(undefined). doi: 10.18632/aging.203825. Online ahead of print.ABSTRACTGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme that participates in various cellular events, such as DNA repair and apoptosis. The functional diversity of GAPDH depends on its intracellular localization. Because AMP-activated protein kinase (AMPK) regulates the nuclear translocation of GAPDH in young cells and AMPK activity significantly increases during aging, we investigated whether altered AMPK activity is involved in the nuclear localization of GAPDH in senescent cells. Age-dependent nucl...
Source: Aging - January 12, 2022 Category: Biomedical Science Authors: Jee Young Sohn Hyeok-Jin Kwak Ji Heon Rhim Eui-Ju Yeo Source Type: research
Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
BMB Rep. 2022 Jan 10:5446. Online ahead of print.ABSTRACTIncreased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpres...
Source: BMB Reports - January 10, 2022 Category: Biochemistry Authors: Natpaphan Yawut Sirichat Kaowinn Il-Rae Cho Phatcharaphon Budluang Seonghye Kim Suhkmann Kim So Eun Youn Sang Seok Koh Young-Hwa Chung Source Type: research
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation
AbstractThe vascular endothelium plays a key role in the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell Piezo1 mediates blood vessel formation, angiogenesis and regulation of blood pressure. However, changes of Piezo1 expression in atherosclerosis (AS) and the role of Piezo1 in the progression of atherosclerotic diseases remains obscure. Thus, the current study is to elucidate the role and mechanism of which Piezo1 mediates vascular inflammation in atherosclerotic mice and vascular endothelial inflammation induced by oxidized low density lipoprotein (ox-LDL) in vitro. Here, we have shown that the ...
Source: Human Cell - January 1, 2022 Category: Cytology Source Type: research
Tumor necrosis factor ‑related apoptosis‑inducing ligand is a novel transcriptional target of runt‑related transcription factor 1
Int J Oncol. 2022 Jan;60(1):6. doi: 10.3892/ijo.2021.5296. Epub 2021 Dec 27.ABSTRACTRunt‑related transcription factor 1 (RUNX1), which is also known as acute myeloid leukemia 1 (AML1), has been frequently found with genomic aberrations in human leukemia. RUNX1 encodes a transcription factor that can regulate the expression of hematopoietic genes. In addition, tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) performs an important function for malignant tumors in immune surveillance. However, the regulatory mechanism of TRAIL expression remain to be fully elucidated. In the present study, tetradecanoylph...
Source: International Journal of Oncology - December 27, 2021 Category: Cancer & Oncology Authors: Tatsushi Yoshida Kenta Yamasaki Kenjiro Tadagaki Yasumichi Kuwahara Akifumi Matsumoto Ad èm Ejub Sofovic Noriko Kondo Toshiyuki Sakai Tsukasa Okuda Source Type: research
NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury
In conclusion, 11R-VIVIT administration inhibits IRI-induced NFAT2 activation and prevents AKI-to-CKD progression. Inhibiting NFAT2 may be a promising new therapeutic strategy for preventing renal fibrosis after IR-AKI.PMID:34937917 | DOI:10.1038/s41401-021-00833-y
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Zhi-Yong Xie Wei Dong Li Zhang Meng-Jie Wang Zhen-Meng Xiao Yu-Hua Zhang Wan-Xin Shi Ying Huang Yan Yang Cui-Li Li Lei Fu Xing-Chen Zhao Rui-Zhao Li Zhi-Lian Li Yuan-Han Chen Zhi-Ming Ye Shuang-Xin Liu Zheng Dong Xin-Ling Liang Source Type: research
