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Condition: Ischemic Stroke

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Total 193 results found since Jan 2013.

Salidroside alleviates Ischemic Brain Injury in Mice with Ischemic Stroke through regulating BDNK mediated PI3K/Akt Pathway.
In this study, We preformed MCAO model in C57BL/6J wild-type (BDNK+/+) and BDNK knockout (BDNF-/-) mice respectively, and investigated the neuroprotective effect of Salidroside (Sal) and its underlying mechanisms. The results showed that Sal reversed brain infarct size, reduced cerebral edema, decreased the neurological deficit score and diminished TUNEL positive cells significantly. However, BDNK deficiency inhibited the neuroprotective effect of Sal. In addition, Sal increased cell viability, ameliorated neuron cell injury by decreasing LDH activity, and inhibited cell apoptotic rate. Sal suppressed apoptotic signaling v...
Source: Biochemical Pharmacology - August 13, 2018 Category: Drugs & Pharmacology Authors: Zhang X, Du Q, Yang Y, Wang J, Liu Y, Zhao Z, Zhu Y, Liu C Tags: Biochem Pharmacol Source Type: research

LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function.
Abstract Lanthionine synthetase C-like protein 1 (LanCL1) is homologous to prokaryotic lanthionine cyclases, and has been shown to have novel functions in neuronal redox homeostasis. A recent study showed that LanCL1 expression was developmental and activity-dependent regulated, and LanCL1 transgene protected neurons against oxidative stress. In the present study, the potential protective effects of LanCL1 against ischemia was investigated in an in vitro model mimicked by oxygen and glucose deprivation (OGD) in neuronal HT22 cells. We found that OGD exposure induced a temporal increase and persistent decreases in ...
Source: Brain Research Bulletin - July 31, 2018 Category: Neurology Authors: Xie Z, Cao BQ, Wang T, Lei Q, Kang T, Ge CY, Gao WJ, Hui H Tags: Brain Res Bull Source Type: research

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1α abundance in rats following focal cerebral ischaemia
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA transfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis and ce...
Source: Brain, Behavior, and Immunity - July 11, 2018 Category: Neurology Source Type: research

Taurine Reduces tPA (Tissue-Type Plasminogen Activator)-Induced Hemorrhage and Microvascular Thrombosis After Embolic Stroke in Rat Basic Sciences
Conclusions—Our results suggest that taurine in combination with tPA may be a clinically feasible approach toward future attempts at combination stroke therapy.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Rong Jin, Adam Y. Xiao, Shan Liu, Min Wang, Guohong Li Tags: Animal Models of Human Disease, Ischemic Stroke Original Contributions Source Type: research

CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways.
Abstract White matter (WM) is injured in most strokes, which contributes to functional deficits during recovery. Casein kinase 2 (CK2) is a protein kinase that is expressed in brain, including WM. To assess the impact of CK2 inhibition on axon recovery following oxygen glucose deprivation (OGD), mouse optic nerves (MONs), which are pure WM tracts, were subjected to OGD with or without the selective CK2 inhibitor CX-4945. CX-4945 application preserved axon function during OGD and promoted axon function recovery when applied before or after OGD. This protective effect of CK2 inhibition correlated with preservation o...
Source: Neurobiology of Disease - June 23, 2018 Category: Neurology Authors: Bastian C, Quinn J, Tripathi A, Aquila D, Dutta AMR, Baltan S, Brunet S Tags: Neurobiol Dis Source Type: research

Upregulation of NOX2 and NOX4 Mediated by TGF- β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury
Conclusions: Our studies demonstrated that TGF- β signaling activation is involved in the regulation of NOX2/NOX4 expression and exacerbates cerebral I/R injury.Cell Physiol Biochem 2018;46:2103 –2113
Source: Cellular Physiology and Biochemistry - May 3, 2018 Category: Cytology Source Type: research

Functional importance of the TGF- β1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia.
Functional importance of the TGF-β1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia. Int J Biol Macromol. 2018 Apr 25;: Authors: Yu Y, Li J, Zhou H, Xiong Y, Wen Y, Li H Abstract We investigated the transforming growth factor-b1 (TGF-β1)/Smad3 signaling pathway in rats with cerebral ischemia and oxygen-glucose-deprived (OGD) microglia. Cerebral ischemia is a clinical condition that occurs when insufficient blood flows to the brain to maintain metabolic activity. TGF-β1 is a well-known functional peptide that regulates cell differentiation, migratio...
Source: International Journal of Biological Macromolecules - April 25, 2018 Category: Biochemistry Authors: Yu Y, Li J, Zhou H, Xiong Y, Wen Y, Li H Tags: Int J Biol Macromol Source Type: research

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1 α abundance in rats following focal cerebral ischaemia
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA tranfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis and cel...
Source: Brain, Behavior, and Immunity - April 19, 2018 Category: Neurology Source Type: research

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1 α abundance in rats following focal cerebral ischaemia.
In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA tranfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis and cel...
Source: Brain, Behavior, and Immunity - April 18, 2018 Category: Neurology Authors: Chen X, Zhang X, Chen T, Jiang X, Wang X, Lei H, Wang Y Tags: Brain Behav Immun Source Type: research

S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats
In conclusion, our findings strongly suggest that S-ORC could be used as an effective neuroprotective agent for ischemic stroke due to its effect in preventing neuronal apoptosis.
Source: Neurochemistry International - April 14, 2018 Category: Neuroscience Source Type: research

Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury
In this study, we used multimodal imaging to assess edema formation and quantify the amount of metabolically functional brain salvaged after a rat model of stroke reperfusion. TRPM4 upregulation in endothelium emerges as early as 2  h post-stroke induction. Expression of TRPM4 channel was suppressed directly in vivo by treatment with siRNA; scrambled siRNA was used as a control. T2-weighted MRI suggests that TRPM4 inhibition successfully reduces edema by 30% and concomitantly salvages functionally active brain, measured by18F-FDG-PET. These in vivo imaging results correlate well with post-mortem 2,3,5-triphenyltetrazolium...
Source: Translational Stroke Research - March 22, 2018 Category: Neurology Source Type: research

Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2 α attenuates focal ischemic brain damage in mice.
Adenoviruses-mediated RNA interference targeting cytosolic phospholipase A2α attenuates focal ischemic brain damage in mice. Mol Med Rep. 2018 Feb 15;: Authors: Wu H, Liu H, Zuo F, Zhang L Abstract Cerebral ischemia injury is a clinical, frequently occurring disease, which causes a heavy burden on society and families. It has been demonstrated that cytosolic phospholipase A2α (cPLA2α) is significant in neurological injury caused by ischemic brain injury, and inhibition of cPLA2α may reduce stroke injury. In the present study, the role of cPLA2α was investigated in a mouse model of middle cerebral...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats.
Abstract Adiponectin is an important adipocyte-derived plasma protein that has beneficial effects on cardio- and cerebrovascular diseases. A low level of plasma Adiponectin is associated with increased mortality post ischemic stroke; however, little is known about the causal role of Adiponectin as well as its molecular mechanisms in neonatal hypoxia ischemia (HI). In the present study, ten-day-old rat pups were subjected to right common carotid artery ligation followed by 2.5 h hypoxia. Recombinant human Adiponectin (rh-Adiponectin) was administered intranasally 1 h post HI. Adiponectin Receptor 1 (AdipoR1) si...
Source: Neuropharmacology - February 24, 2018 Category: Drugs & Pharmacology Authors: Xu N, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, Guo H, Zhang JH Tags: Neuropharmacology Source Type: research

LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway.
Abstract Ischemic stroke is related to a variety of physiological and pathological processes including autophagy and apoptosis. Growth arrest-specific 5 (GAS5), a long non-coding RNA (lncRNA), is known to negatively regulate cell survival and plays a key role in the pathogenesis of numerous diseases. However, the function and molecular mechanism of lncRNA GAS5 in ischemic stroke have not been reported. Real-time PCR was used to detect GAS5 and microRNA-137 (miR-137) expression in the brain tissues of mice underwent middle cerebral artery occlusion (MCAO) surgery and oxygen-glucose deprivation (OGD)-treated mouse p...
Source: Biochemical and Biophysical Research communications - January 4, 2018 Category: Biochemistry Authors: Chen F, Zhang L, Wang E, Zhang C, Li X Tags: Biochem Biophys Res Commun Source Type: research

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway
Publication date: November 2017 Source:Molecular Immunology, Volume 91 Author(s): Juan Peng, Xian Deng, Wei Huang, Ji-hua Yu, Jian-xiong Wang, Jie-ping Wang, Shi-bin Yang, Xi Liu, Li Wang, Yun Zhang, Xiang-Yu Zhou, Hui Yang, Yan-Zheng He, Fang-yuan Xu Recent studies found that irisin, a newly discovered skeletal muscle-derived myokine during exercise, is also synthesized in various tissues of different species and protects against neuronal injury in cerebral ischemia. The NOD-like receptor pyrin 3 (NLRP3) inflammasome play an important role in detecting cellular damage and mediating inflammatory responses to aseptic tissu...
Source: Molecular Immunology - October 1, 2017 Category: Allergy & Immunology Source Type: research