Filtered By:
Condition: Ischemic Stroke
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 193 results found since Jan 2013.
Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice
This study investigated the effect of CAG on the phenotype polarization of microglia in lipopolysaccharide (LPS)-stimulated BV-2 mouse microglial cells and ischemic stroke mice. In LPS-treated BV-2 cells, we found that CAG significantly reduced the expression of M1 markers, including pro-inflammatory cytokines and enzymes. In contrast, CAG promoted the expression of M2 markers, including anti-inflammatory cytokines and growth factor. In addition, CAG inhibited the activation of nuclear factor-κB (NF-κB) and enhanced the activation of nuclear factor E2-related factor 2 (Nrf2) and the expression of its downstream heme oxyg...
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Ting Chen Ziqing Li Shichun Li Yingxiang Zou Xinyi Gao Shi Shu Zhifei Wang Source Type: research
Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research
LncRNA PEG11as silencing sponges miR-874-3p to alleviate cerebral ischemia stroke via regulating autophagy < em > in vivo < /em > and < em > in vitro < /em >
Aging (Albany NY). 2022 Jun 24;14(undefined). doi: 10.18632/aging.204140. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are reportedly involved in the regulation of physiological and pathophysiological processes. However, the potential role of lncRNAs in stroke remains largely undefined. Here, RNA-Seq analysis of lncRNAs found that the lncRNA PEG11as (PEG11as) levels were significantly increased in ischemic brain tissue in a transient middle cerebral artery occlusion/reperfusion (tMCAO/R) mouse model of stroke. To explore the role of PEG11as in stroke, the lentivirus containing PEG11as silencing construct(si...
Source: Aging - June 24, 2022 Category: Biomedical Science Authors: Xiamin Hu Fuyun Ma Zhongliang Cheng Suyou Zeng Ruling Shen Xuan Li Junqi Hu Zhigang Jin Jinping Cheng Source Type: research
Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia –Induced Blood–Brain Barrier Disruption Through NAD+/SIRT1 Signaling Pathway
In conclusion, these findings indicate that rh-NMNAT1 protects BBB integrity after cerebral ischemia via the NAD+/SIRT1 signaling pathway in brain microvascular endothelial cells. NMNAT1 may be a novel potential therapeutic target for reducing BBB disruption after ischemic stroke.
Source: Molecular Neurobiology - June 3, 2022 Category: Neurology Source Type: research
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF- κB and SOX5/PI3K/AKT pathways
Pharmacol Res. 2022 Apr 25:106230. doi: 10.1016/j.phrs.2022.106230. Online ahead of print.ABSTRACTIschemic stroke reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress, and inflammation, but the existing therapeutic strategies have been limited. Moreover, the regulation of microglia plays an important role in brain injury after reperfusion. Hence, it is imperative to find new and effective drugs for modulating microglia to treat IR brain injury. Cyclic peptide compound cyclo-(Phe-Tyr) (Sparganin C, SC) is a compound isolated from Sparganii Rhizoma. However, the protective effects of SC on the c...
Source: Cell Research - April 28, 2022 Category: Cytology Authors: Jiale Cai Jiayin Liang Yutong Zhang Lin Shen Huiting Lin Tao Hu Sikai Zhan Meixia Xie Shengwang Liang Minghua Xian Shumei Wang Source Type: research
Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia/macrophage polarization through Nrf2 and NF- κB pathways
Neuropharmacology. 2022 Apr 19:109064. doi: 10.1016/j.neuropharm.2022.109064. Online ahead of print.ABSTRACTMicroglia are immune cells in the central nervous system (CNS) that participate in response to pathological process after ischemic injury. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is an effective neuroprotective factor that is also known as a metabolic regulator. The present study aimed to investigate the effects and mechanism of the neuroprotective ability of nmFGF1 on microglia in mice after photothrombosis (PT) stroke model, to determine whether it could ameliorate ischemic injury in stroke experiment. We...
Source: Neuropharmacology - April 22, 2022 Category: Drugs & Pharmacology Authors: Confidence Dordoe Xue Wang Ping Lin Zhengyi Wang Jian Hu Dongxue Wang Yani Fang Fei Liang Shasha Ye Jun Chen Yeli Zhao Ye Xiong Yunjun Yang Li Lin Xianfeng Li Source Type: research
