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Condition: Ischemic Stroke
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Total 193 results found since Jan 2013.
Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this research, we explored the effect and specific mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury by constructing a transient middle cerebral artery occlusion model in vivo and a glucose and oxygen deprivation/reoxygenation (OGD/R) model in vitro. The results of the in vivo experiments showed that acute treatment with...
Source: Frontiers in Pharmacology - April 1, 2022 Category: Drugs & Pharmacology Source Type: research
Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis
CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.PMID:35322553 | DOI:10.1111/cns.13829
Source: CNS Neuroscience and Therapeutics - March 24, 2022 Category: Neuroscience Authors: Guangwen Li Xiaoqing Ma Haiping Zhao Junfen Fan Tianwei Liu Yumin Luo Yunliang Guo Source Type: research
The Angiogenesis Effects Of Electro-acupuncture Treatment Via Exosomal miR-210 In Cerebral Ischemia-Reperfusion Rats
CONCLUSION: EA treatment could active the HIF-1α/VEGF/Notch 1 signal pathway to facilitate angiogenesis after ischemic stroke via exosomal miR-210.PMID:35319370 | DOI:10.2174/1567202619666220321115412
Source: Current Neurovascular Research - March 23, 2022 Category: Neurology Authors: Shu-Ying Xu Chun-Li Zeng Si-Ming Ni Yong-Jun Peng Source Type: research
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction
Eur J Pharm Sci. 2022 Mar 5:106164. doi: 10.1016/j.ejps.2022.106164. Online ahead of print.ABSTRACTAtherosclerosis is the common pathophysiological foundation of ischaemic stroke and myocardial ischaemia. Oxidative stress is intricately related to the progress of atherosclerosis. DL-3-n-butylphthalide (NBP) is a synthesized raceme of L-3-n-butylphthalide that is first isolated from celery. As a neuroprotective agent, NBP also exhibits potent antioxidative activity. Our research aimed to evaluate the effect of NBP on atherosclerosis and to explore the underlying antioxidative mechanisms and targets. Firstly, we detected the...
Source: European Journal of Pharmaceutical Sciences - March 8, 2022 Category: Drugs & Pharmacology Authors: Jibo Han Xiaowen Shi Jiajun Xu Wante Lin Yanghao Chen Bingjiang Han Yi Wang Jianjiang Xu Source Type: research
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1 α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury
In conclusion, our results suggested that ISO combined with NT-1 could promote angiogenesis, recover long-term neurobehavioral function, and attenuate cerebral ischemia injury by activating the HIF-1α-Netrin-1-UNC5B/VEGF cascade.PMID:35247371 | DOI:10.1016/j.expneurol.2022.114028
Source: Experimental Neurology - March 5, 2022 Category: Neurology Authors: Nian Li Xu Zhang Jingwen Zhai Jiangwen Yin Ketao Ma Ruixue Wang Xinlei Qin Yan Li Xiwei Dong Sheng Wang Source Type: research
