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Condition: Ischemic Stroke

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Total 193 results found since Jan 2013.

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Abstract Oxidative stress-induced DNA damage results in over-activation of poly(ADP-ribose) polymerase 1 (PARP1), leading to parthanatos, a newly discovered cell elimination pathway. Inhibition of PARP1-dependent cell death has shown to improve the outcome of diseases, including stroke, heart ischemia, and neurodegenerative diseases. In the present study we aimed to detect whether estrogen plays a protective role in inhibiting parthanatos. We utilized human mammary adenocarcinoma cells (MCF7) that abundantly express the estrogen receptor alpha and beta (ERα and ERβ). Parthanatos was induced by challenging the ce...
Source: Toxicology Letters - September 30, 2014 Category: Toxicology Authors: Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio AA, Zeng X, Huo H, Han L, Boldogh I, Ba X Tags: Toxicol Lett Source Type: research

Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats Basic Sciences
Conclusions— Recombinant FSTL1 decreases neuronal apoptosis and improves neurological deficits through phosphorylation of Akt by activation of its receptor DIP2A after MCAO in rats. Thus, FSTL1 may have potentials as a treatment for patients with ischemic stroke.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Liang, X., Hu, Q., Li, B., McBride, D., Bian, H., Spagnoli, P., Chen, D., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Apoptosis, Neuroprotectors Basic Sciences Source Type: research

Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox.
Abstract Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a non-receptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration in neurons. The inhibitory strategy of them is believed to be the promising treatment of stroke. The present study was designed to investigate the effect of equol (0.625-2.5 mg•kg(-1), i.g. for 3 days), a predominant active metabolite of daidzein, on neuroprotection against cerebral ischemia/reperfusion injury in rats and the underlying mechanisms. We found that equ...
Source: Current Neurovascular Research - September 7, 2014 Category: Neurology Authors: Wei YU, Wang Y, Zhou DX, Zhao LM, Li GR, Deng XL Tags: Curr Neurovasc Res Source Type: research

Upregulation of Hsp72 mediates anoxia/reoxygention neuroprotection in the freshwater turtle via modulation of ROS.
Abstract The neuroprotective role of Hsp72 has been demonstrated in several ischemic/stroke models to occur primarily through mediation of apoptotic pathways, and a number of heat shock proteins are upregulated in animal models capable of extended anoxic survival. In the present study, we investigated the role of Hsp72 on cell death and apoptotic regulators in one anoxia tolerant model system, the freshwater turtle Trachemys scripta. Since Hsp72 is known to regulate apoptosis through interactions with Bcl-2, we manipulated the levels of Hsp72 and Bcl-2 with siRNA in neuronally enriched primary cell cultures and ex...
Source: Brain Research - August 5, 2014 Category: Neurology Authors: Kesaraju S, Nayak G, Prentice HM, Milton SL Tags: Brain Res Source Type: research

IL-8 enhances angiogenesis of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/Akt and MAPK/ERK signal transduction pathways and that administration of IL-8-treated hBM-MSCs increases angiogenesis after stroke. This approach may be used to optimize MSC-based therapies for numerous diseases including stroke, myocardial ischemia, and spinal cord injury. PMID: 24797366 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 5, 2014 Category: Cytology Authors: Hou Y, Ryu CH, Jun JA, Kim SM, Jeong CH, Jeun SS Tags: Cell Biol Int Source Type: research

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy.
In this study, the effects of miRNA-30a on ischemic injury in N2A cells and cultured cortical neurons after oxygen glucose deprivation (OGD), and mouse brain with MCAO-induced ischemic stroke were evaluated. The results showed that miRNA-30a expression levels were up regulated in the brain of mice after 6 h MCAO without reperfusion, but significantly down regulated in the peri-infarct region of mice with 1 h MCAO/24 h reperfusion and in N2A cells after 1 h OGD/6-48 h reoxygenation. Both the conversion ratio of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I and Beclin 1 protein level increased in N2A cel...
Source: Neurochemical Research - April 26, 2014 Category: Neuroscience Authors: Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J Tags: Neurochem Res Source Type: research

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 20, 2013 Category: Neurology Authors: Ying‐Na Li, Rong Pan, Xu‐Jun Qin, Wei‐Lin Yang, Zhifeng Qi, Wenlan Liu, Ke Jian Liu Tags: Original Article Source Type: research

TRPM4 inhibition promotes angiogenesis after ischemic stroke.
Abstract Transient receptor potential melastatin 4 (TRPM4) is a voltage-dependent, nonselective cation channel. Under pathological conditions, sustained activation of TRPM4 leads to oncotic cell death. Here, we report the upregulation of TRPM4 in vascular endothelium following hypoxia/ischemia in vitro and in vivo. In human umbilical vein endothelial cells, TRPM4 expression was increased at both the mRNA and protein levels following oxygen-glucose deprivation. Blocking TRPM4 with 9-phenanthrol greatly enhanced tube formation on Matrigel. In a rat permanent middle cerebral artery occlusion model, TRPM4 was upregula...
Source: Pflugers Archiv : European Journal of Physiology - September 17, 2013 Category: Physiology Authors: Loh KP, Ng G, Yu CY, Fhu CK, Yu D, Vennekens R, Nilius B, Soong TW, Liao P Tags: Pflugers Arch Source Type: research

Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
In conclusion, EA pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia, suggesting that STAT3 activation may be a novel target for stroke intervention. PMID: 23880371 [PubMed - as supplied by publisher]
Source: Brain Research - July 20, 2013 Category: Neurology Authors: Zhou H, Zhang Z, Wei H, Wang F, Guo F, Gao Z, Marsicano G, Wang Q, Xiong L Tags: Brain Res Source Type: research

The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.
CONCLUSIONS: PDCD5-induced apoptosis and over-expression of PDCD5 are harmful to the ischemic neurons in vivo. Meanwhile, the inhibition of PDCD5 may be protective via reducing the apoptotic-related protein such as p53, Bax, and caspase-3. This observation may have potential for the treatment of ischemic cerebral stroke. PMID: 23638963 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen YY, Han JY, Zhang JH, Zhou CM Tags: CNS Neurosci Ther Source Type: research

A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
In this study, elderly male Wistar rats received a combination of two mild transient middle cerebral artery occlusions (tMCAOs) as an in vivo recurrent ischemic model. Primary cultured cortical neuronal cells subjected to combined oxygen–glucose deprivation (OGD) were used as an in vitro recurrent ischemic model. RSV administration significantly reduced infarct volumes, improved behavioral deficits and protected neuronal cells from cell death in recurrent ischemic stroke models in vivo and in vitro. RSV treatments significantly increased the intracellular NAD+/NADH ratio, AMPK and SIRT1 activities, decreased energy assum...
Source: European Journal of Neuroscience - March 5, 2013 Category: Neuroscience Authors: Li‐Mei Wang, Yong‐Jiu Wang, Min Cui, Wen‐Juan Luo, Xiao‐Ji Wang, Philip A. Barber, Zhe‐Yu Chen Tags: Research Report Source Type: research

Calmodulin Kinase IV–dependent CREB activation is required for neuroprotection via NMDA receptor‐PSD95 disruption
This study highlights the importance of maintaining neuronal function following ischaemic injury. Future stroke research should target neurotrophic and pro‐survival signal pathways in the development of novel neuroprotective strategies. We propose that uncoupling NMDA receptors from PSD95 provides neuroprotection from stroke by enhancing Ca2+/Calmodulin‐dependent neurotrophic signalling. Blocking NMDAR‐PSD95 interactions allows enhanced activation of nuclear CaM‐kinase IV and prolonged phosphorylation of the CREB transcription factor, resulting in enhanced neurotrophic transcription. These findings demonstrate the...
Source: Journal of Neurochemistry - March 3, 2013 Category: Neurology Authors: Karen F. S. Bell, Russell J. Bent, Saira Meese‐Tamuri, Alicia Ali, Joan P. Forder, Michelle M. Aarts Tags: Original Article Source Type: research

Calmodulin Kinase IV‐dependent CREB activation is required for neuroprotection via NMDA receptor‐PSD95 disruption
This study highlights the importance of maintaining neuronal function following ischemic injury. Future stroke research should target neurotrophic and pro‐survival signal pathways in the development of novel neuroprotective strategies. © 2013 International Society for Neurochemistry, J. Neurochem. (2013) 10.1111/jnc.12176
Source: Journal of Neurochemistry - January 31, 2013 Category: Neurology Authors: Karen F. S. Bell, Russell J. Bent, Saira Meese‐Tamuri, Alicia Ali, Joan P. Forder, Michelle M. Aarts Tags: Original Article Source Type: research