Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1α abundance in rats following focal cerebral ischaemia

In this study, we identified that inhibition of immunoproteasome LMP2 was able to enhance angiogenesis and facilitate neurological functional recovery in rats after focal cerebral ischemia/reperfusion. In vitro, oxygen-glucose deprivation and reperfusion (OGD/R) significantly enhanced the expression of immunoproteasome LMP2 and proteasome activities in primary culture astrocytes, but these beneficial effects were abolished by knockdown of LMP2 with siRNA transfection. Along with this, protein abundance of HIF-1α was significantly increased by inhibition LMP2 in vivo and in vitro and was associated with angiogenesis and cell fates. However, these beneficial effects were partly abolished by HIF-1α inhibitor 2-methoxyestradiol (2ME). Taken together; this study highlights an important role for inhibition of LMP2 in promoting angiogenesis events in ischemic stroke, and point to HIF-1α as a key mediator of this response, suggesting that immunoproteasome inhibitors may be a promising strategy for stroke treatment.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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Conclusion: These results indicate that MALAT1/MDM2/p53 signaling pathway axis may provide more effective clinical therapeutic strategy for patients with ischemic stroke.Cell Physiol Biochem 2018;50:2216 –2228
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Cerebrovasc Dis 2018;46:211 –212
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
Cerebrovasc Dis 2018;46:210
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
ConclusionsIn moderately anemic patients with ABI, RBC transfusion was associated with longer hospital and ICU LOS. Prospective investigations are necessary to further assess these relationships.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Authors: Undas A, Zabczyk M Abstract Fibrin constitutes a major protein component of intravascular thrombi in all locations. Fibrin formation and its functions are essential for physiological hemostasis and the pathologic thrombosis. Formation of dense fibrin networks which are relatively resistant to lysis is observed in patients with venous or arterial thromboembolism, including myocardial infarction, ischemic stroke and venous thromboembolism. Measures of clot characteristics, in particular clot permeability and clot lysis time, may predict arterial and venous recurrent thromboembolic events. Medications, includ...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Publication date: Available online 11 November 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Rui Li, Yuan Huang, Li Chen, Haihui Zhou, Mingwan Zhang, Lei Chang, Hong Shen, Meiling Zhou, Ping Su, Dongya ZhuAbstractThe lack of effective therapies mandates the development of new treatment strategies for ischemic stroke. The NR2B9c peptide can prevent N-Methyl-D-aspartate receptor (NMDAR)-mediated neurotoxicity induced by ischemia without affecting essential NMDAR activity and brings hope for stroke therapy. However, it is very difficult for NR2B9c to cross by itself the blood–brain barrier (BB...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
ConclusionThe perforating vessels branching off of the pathologic VBDE may result in both ischemia and hemorrhage. This is the first known case, to our knowledge, in which hemorrhage and cerebral ischemia occurred simultaneously.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractBackgroundCervicocerebral artery dissection (CAD) is a major cause of ischemic stroke in young adults. There are many existing studies on determinants for CAD; however, they are still not totally defined. We conduct the study to further investigate the determinants for CAD based on ischemic stroke patients.Methods81 ischemic stroke patients with CAD were enrolled in the CAD stroke group and 84 ischemic stroke patients without CAD were enrolled in the non-CAD stroke group. Their clinical data, such as age, gender, vascular risk factors, headache and neck pain and clinical laboratory data, were collected to analyze t...
Source: Journal of Neurology - Category: Neurology Source Type: research
Publication date: Available online 10 November 2018Source: Journal of NeuroradiologyAuthor(s): Mourad Cheddad El Aouni, Jean-Christophe Gentric, Julien OgnardAbstractThe Woven EndoBridge (WEB) device is intended to treat wide-neck bifurcation aneurysms. the morbimortality reported in the literature is low. Described postoperative thromboembolic complications of WEB are fairly limited in terms of chronology and management, as low rates of thromboembolic complications at more than one week of treatment are reported. A 60-year-old patient was treated for an unruptured wide-necked middle cerebral artery (MCA) bifurcation aneur...
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Hmwe Hmwe Kyu, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Molla Abebe, Zegeye Abebe, Olifan Zewdie Abil, Victor Aboyans, Aklilu Roba Abrham, Laith Jamal Abu-Raddad, Niveen M E Abu-Rmeileh, Manfred Mario Kokou AccrombessiSummaryBackgroundHow long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading ...
Source: The Lancet - Category: General Medicine Source Type: research
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