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Condition: Scleroderma

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Total 44 results found since Jan 2013.

S100A4 amplifies TGF-{beta}-induced fibroblast activation in systemic sclerosis
Conclusions We characterised S100A4 as a downstream mediator of the stimulatory effects of TGF-β on fibroblasts in SSc. TGF-β induces the expression of S100A4 to stimulate the release of collagen in SSc fibroblasts and induce fibrosis. Since S100A4 is essentially required for the pro-fibrotic effects of TGF-β and neutralising antibodies against S100A4 are currently evaluated, S100A4 might be a candidate for novel antifibrotic therapies.
Source: Annals of the Rheumatic Diseases - August 10, 2015 Category: Rheumatology Authors: Tomcik, M., Palumbo-Zerr, K., Zerr, P., Avouac, J., Dees, C., Sumova, B., Distler, A., Beyer, C., Cerezo, L. A., Becvar, R., Distler, O., Grigorian, M., Schett, G., Senolt, L., Distler, J. H. W. Tags: Immunology (including allergy), Connective tissue disease Basic and translational research Source Type: research

Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in pro-thrombotic condition.
CONCLUSIONS: Endothelial EPCR down-regulation due to Fli1 deficiency may contribute to hyper-coagulation status leading to tissue fibrosis and impaired peripheral circulation in SSc. This article is protected by copyright. All rights reserved. PMID: 26399195 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - September 24, 2015 Category: Dermatology Authors: Saigusa R, Asano Y, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S Tags: Br J Dermatol Source Type: research

Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20.
This article is protected by copyright. All rights reserved. PMID: 26724675 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - January 2, 2016 Category: Allergy & Immunology Authors: Sisto M, Barca A, Lofrumento DD, Lisi S Tags: Clin Exp Immunol Source Type: research

Epigenetic Regulation of Cyclooxygenase-2 by methylation of c8orf4 in Pulmonary Fibrosis.
Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis produce low levels of prostaglandin E2, due to a limited capacity to up-regulate cyclooxygenase-2. This deficiency contributes functionally to the fibroproliferative state, however the mechanisms responsible are incompletely understood.In the present study we examined whether the reduced level of cyclooxygenase-2 mRNA expression observed in fibrotic lung fibroblasts is regulated epigenetically. The DNA methylation inhibitor, 5 Aza-2’-deoxycytidine restored cyclooxygenase-2 mRNA expression by fibrotic lung fibrobla...
Source: Clinical Science - January 7, 2016 Category: Biomedical Science Authors: Evans, I. C., Barnes, J. L., Garner, I. M., Pearce, D. R., Maher, T. M., Shi-wen, X., Renzoni, E. A., Wells, A. U., Denton, C. P., Laurent, G. J., Abraham, D. J., McAnulty, R. J. Tags: PublishAheadOfPrint Source Type: research

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis
Conclusions Our data identify TWIST1 as a central pro-fibrotic factor in SSc, which facilitates fibroblast activation by amplifying TGFβ signalling. Targeting of TWIST1 may thus be a novel approach to normalise aberrant TGFβ signalling in SSc.
Source: Annals of the Rheumatic Diseases - December 8, 2016 Category: Rheumatology Authors: Palumbo-Zerr, K., Soare, A., Zerr, P., Liebl, A., Mancuso, R., Tomcik, M., Sumova, B., Dees, C., Chen, C.-W., Wohlfahrt, T., Mallano, T., Distler, A., Ramming, A., Gelse, K., Mihai, C., Distler, O., Schett, G., Distler, J. H. W. Tags: Immunology (including allergy), Connective tissue disease Basic and translational research Source Type: research

The impact of transcriptional factor Fli1 deficiency on the regulation of angiogenesis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 31, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: Regular Article Source Type: research

Sirtuin 7 is Decreased in Pulmonary Fibrosis and Regulates the Fibrotic Phenotype of Lung Fibroblasts.
In conclusion, the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels. PMID: 28385812 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - April 6, 2017 Category: Respiratory Medicine Authors: Wyman AE, Noor Z, Fishelevich R, Lockatell V, Shah NG, Todd NW, Atamas SP Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.
CONCLUSION: CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of SSc. PMID: 28507181 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - May 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
In conclusion, the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.
Source: AJP: Lung Cellular and Molecular Physiology - June 5, 2017 Category: Respiratory Medicine Authors: Wyman, A. E., Noor, Z., Fishelevich, R., Lockatell, V., Shah, N. G., Todd, N. W., Atamas, S. P. Tags: RESEARCH ARTICLE Source Type: research

The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis
Abstract The insufficiency of Friend leukaemia virus integration 1 (Fli1), a member of the Ets family transcription factors, is implicated in the pathogenesis of vasculopathy associated with systemic sclerosis (SSc). Fli1 deficiency accelerates early steps of angiogenesis, including detachment of pre‐existing pericytes and extracellular matrix degradation by endothelial proteinases, but the impact of Fli1 deficiency on the other steps of angiogenesis has not been investigated. Therefore, we evaluated the effect of Fli1 deficiency on migration, proliferation, cell survival and tube formation of human dermal microvascular ...
Source: Experimental Dermatology - July 10, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: ORIGINAL ARTICLE Source Type: research

Identifying CYR61 as a Potential Anti ‐fibrotic and Pro‐angiogenic Mediator in Scleroderma
ConclusionsWe identified CYR61, which is epigenetically regulated by HDAC5, as a potent anti ‐fibrotic and pro‐angiogenic mediator in SSc. Therapeutic intervention to promote CYR61 activity or increase CYR61 levels might be of potential benefit in SSc.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - March 17, 2019 Category: Rheumatology Authors: Pei ‐Suen Tsou, Dinesh Khanna, Amr H. Sawalha Tags: Full Length Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.
Conclusions: Affymetrix gene array analysis revealed increased NOX4 and reduced SOD2 expression in SSc and IPF fibroblasts. SOD2 silencing in non-ILD control fibroblasts induced a profibrotic phenotype. TGF-β increased NOX4 and inhibited SOD2 expression, while increasing ROS production and myofibroblast differentiation. JQ1 reversed the TGF-β-mediated NOX4/SOD2 imbalance and Nrf2 inactivation and attenuated ROS production and myofibroblast differentiation. The BET proteins Brd3 and Brd4 were shown to bind to the NOX4 promoter and drive TGF-β-induced NOX4 expression. Our data indicate a critical role of BET proteins in p...
Source: Biomed Res - November 15, 2019 Category: Research Authors: Stock CJW, Michaeloudes C, Leoni P, Durham AL, Mumby S, Wells AU, Chung KF, Adcock IM, Renzoni EA, Lindahl GE Tags: Biomed Res Int Source Type: research

CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.
CONCLUSION: Our findings demonstrate that CXCL4 can drive fibroblast activation indirectly via PDGF-BB production by myeloid cells. Hence, targeting PDGF-BB or CXCL4-induced PDGF-BB release could be clinically beneficial for patients with SSc. PMID: 32284212 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - April 9, 2020 Category: Allergy & Immunology Authors: van der Kroef M, Carvalheiro T, Rossato M, de Wit F, Cossu M, Chouri E, Wichers CGK, Bekker CPJ, Beretta L, Vazirpanah N, Trombetta E, Radstake TRDJ, Angiolilli C Tags: J Autoimmun Source Type: research