Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in pro-thrombotic condition.

CONCLUSIONS: Endothelial EPCR down-regulation due to Fli1 deficiency may contribute to hyper-coagulation status leading to tissue fibrosis and impaired peripheral circulation in SSc. This article is protected by copyright. All rights reserved.
PMID: 26399195 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - September 24, 2015 Category: Dermatology Authors: Saigusa R, Asano Y, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S Tags: Br J Dermatol Source Type: research