Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts

In conclusion, the decline in SIRT7 in lung fibroblasts has a profibrotic effect, which is mediated by changes in Smad3 levels.

Source: AJP: Lung Cellular and Molecular Physiology - June 5, 2017 Category: Respiratory Medicine Authors: Wyman, A. E., Noor, Z., Fishelevich, R., Lockatell, V., Shah, N. G., Todd, N. W., Atamas, S. P. Tags: RESEARCH ARTICLE Source Type: research