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Condition: Diabetes
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Total 1499 results found since Jan 2013.
Dual specificity phosphatase 22 suppresses mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK signaling pathway in diabetic nephropathy
In conclusion, DUSP22 suppresses HG-induced mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK pathway, implying its potency in DN treatment.PMID:36561966 | PMC:PMC9748649 | DOI:10.3892/etm.2022.11680
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Na Ren Shanshan Shi Na Zhao Lingyan Zhang Source Type: research
Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research
Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy
In conclusion, the results suggested that GB may improve DN via protecting the kidney from ferroptosis and oxidative stress damage by inhibiting the ubiquitination of GPX4. These findings suggested that GB, a natural medicine, may be an effective therapeutic option for DN.PMID:36411664 | DOI:10.1016/j.biopha.2022.113953
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2022 Category: Drugs & Pharmacology Authors: Jing Chen Zhijie Ou Tiantian Gao Yuwei Yang Anmei Shu Huiqin Xu Yuping Chen Zhiyang Lv Source Type: research
Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function
Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and ADP that signal through purinergic receptors on these cells to disrupt BBB permeability. While this process is primarily protective, unrestricted, uncontrolled barrier disruption during injury or inflammation can lead to serious neurological consequences. Purinergic receptors are broadly classified into two families: the P1 adenosine and P2 nucleotide receptors. The P2 receptors are f...
Source: Frontiers in Physiology - November 21, 2022 Category: Physiology Source Type: research
GDF11 promotes wound healing in diabetic mice via stimulating HIF-1 ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization
Acta Pharmacol Sin. 2022 Nov 8. doi: 10.1038/s41401-022-01013-2. Online ahead of print.ABSTRACTNon-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db (T2DM) mice. In the present study, we elucidated the cellular and molecular mechanisms underlying the action of GDF11 on healing of small skin wound. Single round-shape full-thickness wound of 5-mm diameter with muscle and bone exposed was made o...
Source: Acta Pharmacologica Sinica - November 8, 2022 Category: Drugs & Pharmacology Authors: Ying Zhang Yi-Yuan Zhang Zhen-Wei Pan Qing-Qi Li Li-Hua Sun Xin Li Man-Yu Gong Xue-Wen Yang Yan-Ying Wang Hao-Dong Li Li-Na Xuan Ying-Chun Shao Meng-Meng Li Ming-Yu Zhang Qi Yu Zhange Li Xiao-Fang Zhang Dong-Hua Liu Yan-Meng Zhu Zhong-Yue Tan Yuan-Yuan Zh Source Type: research
ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis
CONCLUSION: Osteoblast ferroptosis under HG conditions is induced by ATF3-mediated inhibition of system Xc- activity, and these events contribute to T2DOP pathogenesis.PMID:36340581 | PMC:PMC9629949 | DOI:10.1155/2022/9872243
Source: Disease Markers - November 7, 2022 Category: Laboratory Medicine Authors: Yantao Zhao Yunxia Du Yijie Gao Zhijie Xu Dexiang Zhao Maowei Yang Source Type: research
