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Total 1499 results found since Jan 2013.
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Conclusion/interpretationMitochondrial HSP60 promotes fatty acid oxidation while repressing mitochondrial stress and inflammation to ameliorate the development of NAFLD by preserving SIRT3 signalling. This study reveals the hepatoprotective effects of HSP60 and indicates that HSP60 could play a fundamental role in the development of therapeutics for NAFLD or type 2 diabetes.Graphical abstract
Source: Diabetologia - March 24, 2023 Category: Endocrinology Source Type: research
20-Hydroxyecdysone inhibits inflammation via SIRT6-mediated NF- κB signaling in endothelial cells
In conclusion, the present study demonstrates that 20E exerts its effect through SIRT6-mediated deacetylation of NF-κB p65 (K310) to inhibit CD40 expression in ECs, and 20E may have therapeutic potential for the treatment of cardiovascular diseases.PMID:36958525 | DOI:10.1016/j.bbamcr.2023.119460
Source: Cell Research - March 23, 2023 Category: Cytology Authors: Zhen Jin Bo Wang Lingxuan Ren Jianjun Yang Zihan Zheng Feng Yao Rongcheng Ding Jianjiang Wang Jianyu He Weirong Wang Guanjun Nan Rong Lin Source Type: research
TYRO3 protects podocyte via JNK/c-jun-P53 pathway
Arch Biochem Biophys. 2023 Mar 21;739:109578. doi: 10.1016/j.abb.2023.109578. Online ahead of print.ABSTRACTPodocyte injury plays a critical role in diabetic kidney disease (DKD). Our previous work demonstrated a protective role of tyrosine-protein kinase receptor TYRO3 in glomerular disease; However, the downstream signaling of TYRO3 remains unclear. Our data showed that genetic ablation of tyro3 in zebrafish recapitulated a nephrotic syndrome phenotype. TYRO3 expression was suppressed by high glucose and TGF-β, which may contribute to the decreased TYRO3 expression in progressive DKD. Moreover, knockdown of TYRO3 expres...
Source: Archives of Biochemistry and Biophysics - March 22, 2023 Category: Biochemistry Authors: Liwen Zhang Song Jiang Jinsong Shi Xiaodong Xu Ling Wang Xiuwen Zhai Qin Hou Weisong Qin Zhaohong Chen Source Type: research
Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy by regulating the AQP1/RhoA/ROCK signaling in streptozotocin-induced diabetic rats
ConclusionSSD alleviates STZ/HFD-induced DPN in rats by inhibiting the AQP1/RhoA/ROCK signaling pathway.
Source: Acta Diabetologica - March 15, 2023 Category: Endocrinology Source Type: research
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes
J Cell Commun Signal. 2023 Mar 14. doi: 10.1007/s12079-023-00735-0. Online ahead of print.ABSTRACTSeveral reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR-98-5p, that is down-regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR-98-5p overexpression significantly decreased the transcript and protein levels of PPP1R15B in hepatic HepG2 cells and increased p-eIF2α expression and these were prevented in the presence of its inhibitor. Two major hepatic h...
Source: Journal of Cell Communication and Signaling - March 14, 2023 Category: Molecular Biology Authors: Rukshar Khan Amit Kumar Verma Malabika Datta Source Type: research
