Filtered By:
Condition: Diabetes
This page shows you your search results in order of date. This is page number 14.
Order by Relevance | Date
Total 1499 results found since Jan 2013.
Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
AbstractEndothelial cells play critical roles in circulatory homeostasis and are also the gateway to the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells can cause, or are caused by, prevalent chronic diseases such as diabetes, cardiovascular disease, and cancer. Modulation of gene expression within endothelial cells could therefore be therapeutically strategic in treating longstanding disease challenges. Lipid nanoparticles (LNP) have emerged as potent, scalable, and tunable carrier systems for delivering nucleic acids, making them attractive vehicles for gene delivery to endothel...
Source: Pharmaceutical Research - February 3, 2023 Category: Drugs & Pharmacology Source Type: research
Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling
In this study, we investigated whether AGEs could exacerbate skeletal muscle atrophy and its related insulin resistance. Mice were exposed to AGEs. Forkhead box O1 (FOXO1) was silenced by a constructed viral vector carrying siRNA. Skeletal muscle atrophy was evaluated by H&E, oil red O, myosin skeletal heavy chain (MHC) and laminin immunofluorescent stains. Reactive oxygen species (ROS) generation was assessed by DHE stain. Western blotting was used to evaluate protein expression and phosphorylation. Insulin resistance was monitored by insulin tolerance test (ITT) and glucose infusion rate (GIR). Mice exposed to AGEs s...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 1, 2023 Category: Physiology Authors: Haixia Du Yanpeng Ma Xiqiang Wang Yong Zhang Ling Zhu Shuang Shi Shuo Pan Zhongwei Liu Source Type: research
GSE85496 Microarray mRNA expression profiling in Stat5b knockdown pancreatic beta cell line
Contributors : Malini Laloraya ; Annu JosephSeries Type : Expression profiling by arrayOrganism : Mus musculusStat5b gene is located at IDD4 type 1 diabetes susceptibility interval, and is mutated in NOD mice. This mutation has been linked to diabetes with strong association with autoimmune aetiology. We have treated MIN6 pancreatic beta cell line with Stat5b siRNA and analyzed the differential expression profile in control siRNA treated versus Stat5b siRNA treated cells in an effort to understand the role of Stat5b in diabetes.
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Dual specificity phosphatase 22 suppresses mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK signaling pathway in diabetic nephropathy
In conclusion, DUSP22 suppresses HG-induced mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK pathway, implying its potency in DN treatment.PMID:36561966 | PMC:PMC9748649 | DOI:10.3892/etm.2022.11680
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Na Ren Shanshan Shi Na Zhao Lingyan Zhang Source Type: research
