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Condition: Diabetes
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Total 1499 results found since Jan 2013.
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes
J Cell Commun Signal. 2023 Mar 14. doi: 10.1007/s12079-023-00735-0. Online ahead of print.ABSTRACTSeveral reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we show that miR-98-5p, that is down-regulated in the circulation during diabetes, regulates hepatic gluconeogenesis and lipogenesis by targeting PPP1R15B. miR-98-5p overexpression significantly decreased the transcript and protein levels of PPP1R15B in hepatic HepG2 cells and increased p-eIF2α expression and these were prevented in the presence of its inhibitor. Two major hepatic h...
Source: Journal of Cell Communication and Signaling - March 14, 2023 Category: Molecular Biology Authors: Rukshar Khan Amit Kumar Verma Malabika Datta Source Type: research
Inhibition of mammalian target of rapamycin complex 1 in the brain microvascular endothelium ameliorates diabetic A β brain deposition and cognitive impairment via the sterol-regulatory element-binding protein 1/lipoprotein receptor-associated protein 1 signaling pathway
CONCLUSION: Inhibiting mTORC1 in the brain microvascular endothelium ameliorates diabetic Aβ brain deposition and cognitive impairment via the SREBP1/LRP1 signaling pathway, suggesting that mTORC1 may be a potential target for the treatment of diabetic cognitive impairment.PMID:36890627 | DOI:10.1111/cns.14133
Source: CNS Neuroscience and Therapeutics - March 8, 2023 Category: Neuroscience Authors: Gege Jiang Zhenzhen Long Yaoling Wang Yaofeng Wang Ping Xue Minfang Chen Kang Yang Wei Li Source Type: research
Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
CONCLUSION: These results suggest that the SENP2-PPARα pathway plays an important role in leptin-induced FAO in white adipocytes.PMID:36872063 | DOI:10.4093/dmj.2022.0156
Source: Diabetes and Metabolism Journal - March 5, 2023 Category: Endocrinology Authors: Praise Chanmee Kim Ji Seon Lee Sung Soo Chung Kyong Soo Park Source Type: research
Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research
