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Condition: Diabetes
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Total 1499 results found since Jan 2013.
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
We examined the roles of circCOL1A2 in regulating oxidative stress by measuring reactive oxygen species (ROS), lipid peroxidation, and superoxide dismutase (SOD) levels. Besides, the effects of circCOL1A2 silencing on pyroptosis were investigated by RT-qPCR, western blot (WB), and ELISA assays. StarBase (version 2.0) was used to identify the downstream effector of circCOL1A2, and their interactions were further verified through dual-luciferase reporter analysis, RNA pull-down assays, and RNA immunoprecipitation (RIP) assay. CircCOL1A2 was highly expressed in DN patients and HG-induced HK-2 cells. Knocking down circCOL1A2 a...
Source: Applied Biochemistry and Biotechnology - April 20, 2023 Category: Biochemistry Authors: Langen Zhuang Guoxi Jin Wang Qiong Xiaoxu Ge Xiaoyan Pei Source Type: research
A ketogenic diet improves vascular hyperpermeability in type 2 diabetic mice by downregulating vascular pescadillo1 expression
This study probes the role of PES1 and its mediated molecular mechanism in modulating vascular hyperpermeability in diabetic mice. Male C57BL/6J and db/db mice were fed a standard diet and a ketogenic diet (KD). Meanwhile, mouse vascular endothelial cells (MVECs) were treated with β-hydroxybutyric acid (β-HB), Pes1 siRNA or a Pes1 overexpression plasmid. Additionally, knockout (KO) of Pes1 in mice was applied. After 12 weeks of feedings, enhanced vascular PES1 expression in diabetic mice was inhibited by the KD. The suppression of PES1 was also observed in β-HB-treated MVECs. In mice with Pes1 KO, the levels of vascular...
Source: J Cell Mol Med - April 15, 2023 Category: Molecular Biology Authors: Song Wang Jielin Zhou Jing Lu Yan Lin Shuaishuai Liu Keyang Chen Source Type: research
Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE/TFAM signaling in diabetic kidney disease
In this study, using molecular docking we found that Astragaloside IV (AS-IV), an active ingredient from traditional formula of Huangqi decoction (HQD), exerted a higher potential to promote Nrf2 escape from Keap1-Nrf2 interaction via competitively bind to amino acid sites in Keap1. When podocyte exposed to high glucose (HG) stimulation, mitochondrial morphological alterations and podocyte apoptosis were presented and accompanied by Nrf2 and mitochondrial transcription factor A (TFAM) downregulation. Mechanistically, HG promoted a decrease in mitochondria-specific electron transport chain (ETC) complexes, ATP synthesis and...
Source: Free Radical Biology and Medicine - April 8, 2023 Category: Biology Authors: Qian Shen Ji Fang Hengjiang Guo Xue Su Bingbing Zhu Xingmei Yao Yunman Wang Aili Cao Hao Wang Li Wang Source Type: research
Investigation of the Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 in Diabetic Retinopathy
CONCLUSIONS: CEACAM1 might play a role in the pathology of PDR. CEACAM1 might be a therapeutic target for retinal neovasculariztion.PMID:37023410 | DOI:10.1080/09273948.2023.2192272
Source: Ocular Immunology and Inflammation - April 6, 2023 Category: Allergy & Immunology Authors: Yuanqi Wang Junhui Shen Jianghua Hu Houfa Yin Zhiqing Chen Xiaoyun Fang Li Zhang Source Type: research
Buyang huanwu decoction inhibits diabetes-accelerated atherosclerosis via reduction of AMPK-Drp1-mitochondrial fission axis
CONCLUSION: The above findings support the conclusion that BYHWD suppresses diabetes-accelerated atherosclerosis by reducing mitochondrial fission through modulation of the AMPK/Drp1 pathway.PMID:37003404 | DOI:10.1016/j.jep.2023.116432
Source: Atherosclerosis - April 1, 2023 Category: Cardiology Authors: Wanyu Tong Ling Leng Yucheng Wang Jingwen Guo Felix Boahen Owusu Yue Zhang Fang Wang Ruiqiao Li Yuhong Li Yanxu Chang Yuefei Wang Qilong Wang Source Type: research
