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Total 1499 results found since Jan 2013.
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Conclusions/interpretationWe provide the first account of epigenetic changes in diabetic corneas including dual inhibition ofWNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.Data availabilityThe DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328).Graphical Abstract
Source: Diabetologia - September 3, 2023 Category: Endocrinology Source Type: research
Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages
CONCLUSIONS: The findings of this study show that SETDB1 regulates senescence-like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes-induced periodontal inflamm-aging.PMID:37661095 | DOI:10.1111/jcpe.13871
Source: Journal of Clinical Periodontology - September 3, 2023 Category: Dentistry Authors: Ziqi Yue Luningxiao Nie Ning Ji Yuezhang Sun Kangjian Zhu Haonan Zou Xiuxiu Song Jiao Chen Qi Wang Source Type: research
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Conclusions/interpretationWe provide the first account of epigenetic changes in diabetic corneas including dual inhibition ofWNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.Data availabilityThe DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328).Graphical Abstract
Source: Diabetologia - September 1, 2023 Category: Endocrinology Source Type: research
Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose - induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
CONCLUSION: Future studies were required to validate whether plasma galectin-3 might become a potential biomarker for hyperglycemia during pregnancy. Elevated galectin-3 levels might be a vital protective mechanism among those exposed to hyperglycemia during pregnancy.PMID:37626284 | DOI:10.1186/s10020-023-00707-5
Source: Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Yu Deng Hongyan Jin Jie Ning Dong Cui Muqiu Zhang Huixia Yang Source Type: research
Hydrogen sulfide promoted retinoic acid-related orphan receptor α transcription to alleviate diabetic cardiomyopathy
Biochem Pharmacol. 2023 Aug 15:115748. doi: 10.1016/j.bcp.2023.115748. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is one serious and common complication in diabetes without effective treatments. Hydrogen sulfide (H2S) fights against a variety of cardiovascular diseases including DCM. Retinoic acid-related orphan receptor α (RORα) has protective effects on cardiovascular system. However, whether RORα mediates the protective effect of H2S against DCM remains unknown. The present research was to explore the roles and mechanisms of RORα in H2S against DCM. The study demonstrated that H2S donor sodium hydro...
Source: Biochemical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Shuping Zhang Jieru Shen Yu Zhu Yangyang Zheng Wenqin San Danyi Cao Yun Chen Guoliang Meng Source Type: research
SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research
Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells
J Physiol. 2023 Jul 20. doi: 10.1113/JP284871. Online ahead of print.ABSTRACTHigh gestational weight gain (GWG) is a cardiovascular risk factor and may disturb neonatal endothelial function. Long non-coding RNAs (lncRNAs) regulate gene expression epigenetically and can modulate endothelial function. Endothelial colony forming cells (ECFCs), circulating endothelial precursors, are a recruitable source of endothelial cells and sustain endothelial function, vascular growth and repair. We here investigated whether higher GWG affects neonatal ECFC function and elucidated the role of lncRNAs herein. Wound healing of umbilical co...
Source: The Journal of Physiology - July 20, 2023 Category: Physiology Authors: Elisa Weiss Anna Schr üfer Carolina Tocantins Mariana Simoes Diniz Boris Novakovic Anke S van Bergen Azra Kulovic-Sissawo Richard Saffery Reinier A Boon Ursula Hiden Source Type: research
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
CONCLUSIONS/INTERPRETATION: We provide the first account of epigenetic changes in diabetic corneas including dual inhibition of WNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.DATA AVAILABILITY: The DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328 ).PMID:37460827 | DOI:10.1007/s00125-023-05960-1
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ruchi Shah Tanya M Spektor Daniel J Weisenberger Hui Ding Rameshwar Patil Cynthia Amador Xue-Ying Song Steven T Chun Jake Inzalaco Sue Turjman Sean Ghiam Jiho Jeong-Kim Sasha Tolstoff Sabina V Yampolsky Onkar B Sawant Yaron S Rabinowitz Ezra Maguen Pedram Source Type: research
The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway
In this study, we established an in vitro insulin resistance cell model for human HepG2 cells to investigate the possible mechanism of the effect of sitagliptin on glucose metabolism via the SOCS3/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Since insulin resistance first develops in the liver, palmitic acid was used to generate an insulin resistance cell model in human HepG2 cells, after which small interfering ribonucleic acid (siRNA)-SOCS3 and sitagliptin were used to intervene. We then examined the changes in cell viability and biochemical indices in the insulin resistance cell model. SOCS3, Akt, an...
Source: Journal of Physiology and Pharmacology - July 15, 2023 Category: Drugs & Pharmacology Authors: R Ma L Quan Q-Q-G Aleteng L Li J Zhu S Jiang Source Type: research
Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells
In this study, we hypothesized that semaphorin 7a (Sema7a) was involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. For these studies, we used diabetic mouse samples and REC to investigate our hypothesis. Primary retinal endothelial cells were grown in normal (5 mM) or high glucose (25 mM glucose) for measurements. In a subset of cells grown in high glucose, cells were transfected with Sema7a siRNA or scrambled siRNA. We measured levels of key inflammatory mediators and zonula occludens-1 (ZO-1) and occludin levels by Western blot. Data suggest ...
Source: Cell Research - July 15, 2023 Category: Cytology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway
In this study, we established an in vitro insulin resistance cell model for human HepG2 cells to investigate the possible mechanism of the effect of sitagliptin on glucose metabolism via the SOCS3/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Since insulin resistance first develops in the liver, palmitic acid was used to generate an insulin resistance cell model in human HepG2 cells, after which small interfering ribonucleic acid (siRNA)-SOCS3 and sitagliptin were used to intervene. We then examined the changes in cell viability and biochemical indices in the insulin resistance cell model. SOCS3, Akt, an...
Source: Journal of Physiology and Pharmacology - July 15, 2023 Category: Drugs & Pharmacology Authors: R Ma L Quan Q-Q-G Aleteng L Li J Zhu S Jiang Source Type: research
Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells
In this study, we hypothesized that semaphorin 7a (Sema7a) was involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. For these studies, we used diabetic mouse samples and REC to investigate our hypothesis. Primary retinal endothelial cells were grown in normal (5 mM) or high glucose (25 mM glucose) for measurements. In a subset of cells grown in high glucose, cells were transfected with Sema7a siRNA or scrambled siRNA. We measured levels of key inflammatory mediators and zonula occludens-1 (ZO-1) and occludin levels by Western blot. Data suggest ...
Source: Cell Research - July 15, 2023 Category: Cytology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway
In this study, we established an in vitro insulin resistance cell model for human HepG2 cells to investigate the possible mechanism of the effect of sitagliptin on glucose metabolism via the SOCS3/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Since insulin resistance first develops in the liver, palmitic acid was used to generate an insulin resistance cell model in human HepG2 cells, after which small interfering ribonucleic acid (siRNA)-SOCS3 and sitagliptin were used to intervene. We then examined the changes in cell viability and biochemical indices in the insulin resistance cell model. SOCS3, Akt, an...
Source: J Physiol Pharmacol - July 15, 2023 Category: Drugs & Pharmacology Authors: R Ma L Quan Q-Q-G Aleteng L Li J Zhu S Jiang Source Type: research
