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Condition: Diabetes
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Total 1499 results found since Jan 2013.
Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research
Cell surface GRP78 regulates TGF β1-mediated profibrotic responses via TSP1 in diabetic kidney disease
Discussion: These data support an important role for csGRP78 in regulating HG-induced TSP1 transcriptional induction via PI3K/Akt signaling. Functionally, this enables TGFβ1 activation in response to HG, with consequent increase in ECM proteins. Means of inhibiting csGRP78 signaling represent a novel approach to preventing fibrosis in DKD.
Source: Frontiers in Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells
In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autophagic cell death, as evidenced by decreased cell viability, aggravated cell apoptosis, and the accumulation of the p62 protein in MIN6 cells. LysoTracker Red staining, TEM and mRFP-GFP-LC3 assays demonstrate that autophagic flux is blocked in ox-LDL-treated MIN6 cells. Intriguingly, SCGN is significantly decreased in MIN6 cells under lipotoxic conditions. Additionally, siRNA-guided SCGN knockdown blocks autophagic flux triggered by rapamycin, while SCGN restoratio...
Source: Acta Biochimica et Biophysica Sinica - February 15, 2023 Category: Biochemistry Authors: Ying Lv Sijie Xiao Shuhui Ouyang Zhengliang Peng Li Wu Ziqing Tang Weizheng Zhang Renxian Cao Jing Yang Source Type: research
BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun,
Junwei Liu,
Yanzheng Wang,
Hongmei Yang,
Danfeng Song,
Haiyan Fu,
Xingxing Feng Tags: Original Article Source Type: research
Regulation of NcRNA-protein binding in diabetic foot
In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU.PMID:36753956 | DOI:10.1016/j.biopha.2023.114361
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 8, 2023 Category: Drugs & Pharmacology Authors: Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu Source Type: research
Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
Pharm Res. 2023 Feb 3. doi: 10.1007/s11095-023-03471-7. Online ahead of print.ABSTRACTEndothelial cells play critical roles in circulatory homeostasis and are also the gateway to the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells can cause, or are caused by, prevalent chronic diseases such as diabetes, cardiovascular disease, and cancer. Modulation of gene expression within endothelial cells could therefore be therapeutically strategic in treating longstanding disease challenges. Lipid nanoparticles (LNP) have emerged as potent, scalable, and tunable carrier systems for deliverin...
Source: Cell Research - February 3, 2023 Category: Cytology Authors: Gary W Liu Edward B Guzman Nandita Menon Robert S Langer Source Type: research
