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Condition: Diabetes
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Total 1499 results found since Jan 2013.
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease
This study evaluated the potential role of STING in high glucose (HG)-induced podocyte inflammation response. STING expression was significantly increased in db/db mice, STZ-treated diabetic mice, and HG-treated podocytes. Podocyte-specific deletion of STING alleviated podocyte injury, renal dysfunction, and inflammation in STZ-induced diabetic mice. STING inhibitor (H151) administration ameliorated inflammation and improved renal function in db/db mice. STING deletion in podocytes attenuated the activation of the NLRP3 inflammasome and podocyte pyroptosis in STZ-induced diabetic mice. In vitro, modulated STING expression ...
Source: Cellular Signalling - June 17, 2023 Category: Cytology Authors: Xueyan Yang Zhaowei Chen Zilv Luo Dingping Yang Yiqun Hao Jijia Hu Jun Feng Zijing Zhu Qiang Luo Zongwei Zhang Wei Liang Guohua Ding Source Type: research
Mechanisms of MALAT1 regulating proliferative diabetic retinopathy via targeting miR-126-5p
CONCLUSIONS: MALAT1 promotes PDR by inhibiting miR126-5p and inducing REC proliferation, migration and angiogenesis.PMID:37303661 | PMC:PMC10251023
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Wei Zhao Yanli Liu Cairui Li Zhijian Yin Yi Liu Meixia An Source Type: research
