Filtered By:
Condition: Reflex Sympathetic Dystrophy

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 132 results found since Jan 2013.

Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.
Abstract The thyroid hormone triiodothyronine (T3) activates thermogenesis by uncoupling electron transport from ATP synthesis in brown adipose tissue (BAT) mitochondria. Although T3 can induce thermogenesis by sympathetic innervation, little is known about its cell autonomous effects on BAT mitochondria. We thus examined effects of T3 on mitochondrial activity, autophagy, and metabolism in primary brown adipocytes and BAT and found that T3 increased fatty acid oxidation and mitochondrial respiration as well as autophagic flux, mitophagy, and mitochondrial biogenesis. Interestingly, there was no significant induct...
Source: Autophagy - September 13, 2018 Category: Cytology Authors: Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM Tags: Autophagy Source Type: research

Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats
Conclusion: Taken together, our results suggested that enhanced CB1 receptor-mediated neurotransmissions in the RVLM may play a role in the development of obesity-induced hypertension.
Source: Journal of Hypertension - March 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF- κB and MAPK pathways.
P2X7 receptor regulates sympathoexcitatory response in myocardial infarction rats via NF-κB and MAPK pathways. Am J Transl Res. 2017;9(11):4954-4962 Authors: Wu Q, Xu H, Hao L, Ma G, Sun J, Song X, Ding F, Wang N Abstract Previous studies have provided evidence for the regulatory effect of P2X7 receptor (P2X7R) on cardiovascular activities. Our study focused on exploring the function and fundamental mechanism of microglial P2X7R in controlling sympathoexcitatory response using rats with acute myocardial infarction (AMI). Coronary artery ligation was used in rats to cause AMI. And before that, rats wer...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function.
CONCLUSIONS: The corneal endothelium in PPCD3 is characterized by morphologic, anatomic, and molecular features that are more consistent with an epithelial-like rather than an endothelial-like phenotype. Although these characteristics have been well documented, we demonstrate for the first time that susceptibility to UV-induced apoptosis and cell barrier function are significantly altered in the setting of reduced ZEB1. The significance of an altered cellular response to apoptotic stimuli and increased cell barrier function in the pathobiology of PPCD remains to be fully elucidated. PMID: 29046608 [PubMed - in process]
Source: Molecular Vision - October 20, 2017 Category: Molecular Biology Tags: Mol Vis Source Type: research

Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size.
Authors: Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E Abstract Myostatin, a member of the TGF-β superfamily, is a negative regulator of skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB). The soluble ligand-binding domain of ActRIIB fused to the Fc domain of IgG (ActRIIB-Fc) potently binds and inhibits TGF-β family members in muscle, leading to rapid and marked muscle growth. The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal mus...
Source: Journal of Nutritional Science and Vitaminology - October 7, 2017 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFR α3 knockdown.
CONCLUSION: Our results demonstrate that GFRα3 knockdown specially inhibits cold hyperalgesia following CCI via decreasing the expression level and plasma membrane trafficking of TRPM8 in DRG. GFRα3 and its downstream mediator, TRPM8, represent a new analgesia axis which can be further exploited in sensitized cold reflex under the condition of chronic pain. PMID: 28867384 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - August 31, 2017 Category: Neurology Authors: Su L, Shu R, Song C, Yu Y, Wang G, Li Y, Liu C Tags: Brain Res Bull Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

Regulation of Clock Genes by Adrenergic Receptor Signaling in Osteoblasts.
Abstract The clock system has been identified as one of the major mechanisms controlling cellular functions. Circadian clock gene oscillations also actively participate in the functions of various cell types including bone-related cells. Previous studies demonstrated that clock genes were expressed in bone tissue and also that their expression exhibited circadian rhythmicity. Recent findings have shown that sympathetic tone plays a central role in biological oscillations in bone. Adrenergic receptor (AR) signaling regulates the expression of clock genes in cancellous bone. Furthermore, α1-AR signaling in osteobla...
Source: Neurochemical Research - July 27, 2017 Category: Neuroscience Authors: Hirai T Tags: Neurochem Res Source Type: research

PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.
Abstract Activation of PI3K/Akt signaling, leading to upregulation of nitric oxide synthase II (NOS II)/peroxynitrite cascade in the rostral ventrolateral medulla (RVLM), the brain stem site that maintains blood pressure and sympathetic vasomotor tone, underpins cardiovascular depression induced by the organophosphate pesticide mevinphos. By exhibiting dual-specificity protein- and lipid-phosphatase activity, phosphatase and tensin homolog (PTEN) directly antagonizes the PI3K/Akt signaling by dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate, the lipid product of PI3K. Based on the guiding hypothesis t...
Source: Neuropharmacology - June 7, 2017 Category: Drugs & Pharmacology Authors: Tsai CY, Wu JCC, Fang C, Chang AYW Tags: Neuropharmacology Source Type: research

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy
by Sean C. Shadle, Jun Wen Zhong, Amy E. Campbell, Melissa L. Conerly, Sujatha Jagannathan, Chao-Jen Wong, Timothy D. Morello, Silv ère M. van der Maarel, Stephen J. Tapscott Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways necessary for DUX4-mediated apoptosis, we performed an siRNA screen in an RD rhabdomyosarcoma cell line with an inducibleDUX4 transgene. Our screen identified compon...
Source: PLoS Genetics - March 7, 2017 Category: Genetics & Stem Cells Authors: Sean C. Shadle Source Type: research

GSE87495 DUX4-induced dsRNA and MYC mRNA Stabilization Lead to Apoptosis in Human Cell Models of Facioscapulohumeral Dystrophy
Contributors : Sean C Shadle ; Jun W Zhong ; Amy E Campbell ; Melissa L Conerly ; Sujatha Jagannathan ; Chao-Jen Wong ; Timothy D Morello ; Stephen J TapscottSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFacioscapulohumeral muscular dystophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways necessary for DUX4-mediated apoptosis, we performed an siRNA screen in an RD rhabdomyosar...
Source: GEO: Gene Expression Omnibus - December 31, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) involves sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic. To identify target genes, we over-expressed DUX4 in myoblasts and found that the receptor tyrosine kinaseRet was significantly up-regulated, suggesting a role in FSHD.RET is dynamically expressed during myogenic progression in mouse and human myoblasts. Constitutive expression of eitherRET9 orRET51 increased myoblast proliferation, whereas siRNA-mediated knockdown ofRet induced myogenic differentiation. Suppressing RET activity using Sunitinib, a clinically-approved tyrosine kinase inhibitor, ...
Source: eLife - November 14, 2016 Category: Biomedical Science Tags: Cell Biology DUX4 facioscapulohumeral muscular dystrophy FSHD Human Human Biology and Medicine Mouse RET Sunitinib therapy Source Type: research

Norepinephrine Inhibits Mesenchymal Stem Cell Chemotaxis Migration by Increasing Stromal Cell-derived Factor-1 Secretion by Vascular Endothelial Cells via NE/abrd3/JNK Pathway.
Abstract Mesenchymal stem cells (MSCs), which are physiologically maintained in vascular endothelial cell (VEC)-based niches, play a critical role in tissue regeneration. Our previous studies demonstrated that sympathetic denervation could promote MSC mobilization, thereby enhancing bone formation in distraction osteogenesis (DO), a self-tissue engineering for craniofacial and orthopeadic surgeries. However, the mechanisms on how sympathetic neurotransmitter norepinephrine (NE) regulates MSC migration are not well understood. Here we showed that deprivation of NE by transection of cervical sympathetic trunk (TCST)...
Source: Experimental Cell Research - September 16, 2016 Category: Cytology Authors: Wu B, Wang L, Yang X, Mao M, Ye C, Liu P, Yang Z, Yang X, Lei D, Zhang C Tags: Exp Cell Res Source Type: research

Regulating gene expression towards solving ocular surface diseases
SummaryTreatment of genetic eye disease poses significant medical and surgical challenges. We used a bioluminescent corneal reporter gene mouse model to assess efficacy and potency of a number of gene therapy approaches for corneal dystrophy. Various modalities were assessed for delivery of short interfering RNA (siRNA) targeting one of five mutant alleles present in the corneal bioluminescent mouse model enabling assessment of topical, subconjunctival and intrastromal delivery. Potent and sustained in vivo gene silencing >50% for up to 7 days was observed. This siRNA therapy only provides a transient silencing of the ...
Source: Acta Ophthalmologica - September 13, 2016 Category: Opthalmology Authors: T. Moore, S. Atkinson, E. Maurizi, D. Schiroli, L. Mairs, K. Christie, I. McLean, E. Allen, D.L. Pedrioli, J. Moore, A. Nesbit Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

LncRNA NONRATT021972 siRNA rescued decreased heart rate variability in diabetic rats in superior cervical ganglia
Diabetic cardiac autonomic neuropathy (DCAN) is a serious and common complication in diabetes mellitus (DM). Long noncoding RNAs (lncRNAs), an important class of regulatory molecules in diverse biological processes, have attracted considerable interest in DCAN. Our previous study has indicated a lncRNA, NONRATT021972 (NONCODE ID), was enhanced in sympathetic neuronal-like PC12 cells in the setting of high glucose (HG) and high FFAs (HF); its silence was found to significantly alleviate HGHF-induced tumor necrosis factor- α (TNF-α) release in PC12 cells.
Source: Autonomic Neuroscience: Basic and Clinical - August 4, 2016 Category: Neuroscience Authors: Hong Xu, Changle Liu, Shenqiang Rao, Luling He, Tengling Zhang, Shanshan Sun, Bing Wu, Lifang Zou, Shouyu Wang, Yun Xue, Tianyu Jia, Shanhong Zhao, Guilin Li, Shuangmei Liu, Guodong Li, Shangdong Liang Source Type: research