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Condition: Reflex Sympathetic Dystrophy

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Total 132 results found since Jan 2013.

Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons
In this study, we examined whether the γ-secretase pathway also influences dendritic growth in primary sympathetic neurons. Using immunoblotting and immunocytochemistry, molecules of the γ-secretase complex, PSEN1, PSEN2, PEN2, nicastrin and APH1a, were detected in sympathetic neurons dissociated from embryonic (E20/21) rat sympathetic ganglia. Addition of bone morphogenetic protein-7 (BMP-7), which induces dendrites in these neurons, did not alter expression or localization of γ-secretase complex proteins. BMP-7-induced dendritic growth was inhibited by siRNA knockdown of PSEN1 and by three γ-secretase inhibitors, γ-...
Source: Autonomic Neuroscience - April 9, 2023 Category: Neuroscience Authors: Krystal Karunungan Rachel H Garza Ana Cristina Grodzki Megan Holt Pamela J Lein Vidya Chandrasekaran Source Type: research

C-type natriuretic peptide (CNP) in the paraventricular nucleus-mediated renal sympatho-inhibition
In this study, we proposed C-type natriuretic peptide (CNP) as a potential mediator of this sympatho-inhibition within the PVN. Microinjection of CNP (1.0 μg) into the PVN significantly decreased renal sympathetic nerve activity (RSNA) (−25.8% ± 1.8% vs. −3.6% ± 1.5%), mean arterial pressure (−15.0 ± 1.9 vs. −0.1 ± 0.9 mmHg) and heart rate (−23.6 ± 3.5 vs. −0.3 ± 0.9 beats/min) compared with microinjection of vehicle. Picoinjection of CNP significantly decreased the basal discharge of extracellular single-unit recordings in 5/6 (83%) rostral ventrolateral medulla (RVLM)-projecting PVN neurons and in 6/...
Source: Frontiers in Physiology - April 4, 2023 Category: Physiology Source Type: research

Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats
Tumor necrosis factor (TNF)-α converting enzyme (TACE) is a key metalloprotease mediating ectodomain shedding of a variety of inflammatory mediators, substrates, and growth factors. We previously reported that TACE-mediated production of TNF-α in the hypothalamic paraventricular nucleus (PVN) contributes to sympathetic excitation in heart failure (HF). Here, we sought to determine whether central interventions in TACE activity attenuate neuroinflammation and improve cardiac function in heart failure. Myocardial infarction-induced HF or sham-operated (SHAM) rats were treated with bilateral paraventricular nucleus microinj...
Source: Frontiers in Physiology - November 9, 2022 Category: Physiology Source Type: research

NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36
CONCLUSION: We show novel evidence for the CD36-mediated accumulation of oxLDL in BAT, suggesting that BAT may exert its anti-atherogenic effects by removing atherogenic LDL from the circulation.PMID:36266737 | DOI:10.1093/cvr/cvac167
Source: Cell Research - October 21, 2022 Category: Cytology Authors: Kento Hosomi Hidekazu Kawashima Atsushi Nakano Akemi Kakino Yuko Okamatsu-Ogura Yuki Yamashita Mai Sasaoka Daisaku Masuda Shizuya Yamashita Chu-Huang Chen Shunsuke Yuzuriha Hiroshi Hosoda Hidehiro Iida Tatsuya Sawamura Source Type: research

K < sub > V < /sub > 4 channels in isolectin B4 muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease: Effects of bradykinin B1 and B2 receptors
In conclusion, our data suggest that limb ischemia and/or ischemia induced-BK inhibit activity of KV4 channels in a subpopulation of the thin fiber muscle afferent neurons depending on GDNF, which is likely a part of signaling pathways involved in the exaggerated blood pressure response during activation of muscle afferent nerves in PAD.PMID:36094447 | DOI:10.1152/ajpregu.00117.2022
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 12, 2022 Category: Physiology Authors: Qin Li Lu Qin Jianhua Li Source Type: research

GSE161899 The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma siRNA_RRM2
In this study, we identified and functionally evaluated the ‘ribonucleotide reductase regulatory subunit 2’ (RRM2) as a top-ranked 2p putative co-driver and therapeutic target in high-risk neuroblastoma enforcing replicative stress resistance. RRM2 dependency was shown in vitro through knockdown in neuroblastoma cells, with transcriptome analysis reveali ng downregulation of pediatric tumor markers. Transgenic zebrafish lines expressing RRM2 in immature sympathoblasts were crossed with a dh-MYCN transgenic zebrafish line, with RRM2 overexpression dramatically increasing tumor penetrance from 20% to nearly 100%, acce...
Source: GEO: Gene Expression Omnibus - August 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research