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Condition: Heart Disease

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Total 126 results found since Jan 2013.

BNIP3 promotes calcium and calpain-dependent cell death
Publication date: 1 December 2015 Source:Life Sciences, Volume 142 Author(s): Regina M. Graham, John W. Thompson, Keith A. Webster Aims Loss of cardiac muscle by programmed cell death contributes to the progression of ischemic heart disease. Hypoxia, metabolite waste buildup and energy depletion are components of ischemia which may initiate caspase dependent and independent cell death pathways. Previous work from our laboratory has shown that combined hypoxia with acidosis, a hallmark of ischemia promotes cardiac myocyte injury with increasing severity as the pH declines. Hypoxia-acidosis was demonstrated to activate ...
Source: Life Sciences - October 23, 2015 Category: Biology Source Type: research

The roles of nanocarriers on pigment epithelium-derived factor in the differentiation of human cardiac stem cells
In this study, we utilized organically modified silica (ORMOSIL) nanoparticles to deliver small interfering RNA (siRNA) against pigment epithelium-derived factor (PEDF) and induce the differentiation of human cardiac stem cells (CSCs). We found that the down-regulation of PEDF can inhibit the proliferation of human CSCs and induce cell differentiation. To further study the mechanism, we have tested the Notch signalling pathway genes, Hes1 and Hes5, and found that their expressions were inhibited by the PEDF down-regulation. Furthermore, with the restoration of PEDF, both the proliferation of human CSCs and expressions of H...
Source: Cell and Tissue Research - August 12, 2015 Category: Cytology Source Type: research

Ox-LDL Upregulates IL-6 Expression by Enhancing NF-κB in an IGF2-Dependent Manner in THP-1 Macrophages
Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that is well established as a vital factor in determining the risk of coronary heart disease and pathogenesis of atherosclerosis. Moreover, accumulating evidences have shown that oxidized low-density lipoprotein (ox-LDL) can promote IL-6 expression in macrophages. Nevertheless, the underlying mechanism of how ox-LDL upregulates IL-6 expression remains largely unexplained. We found that the expression of insulin-like growth factor 2 (IGF2), nuclear factor kappa B (NF-κB), and IL-6 was upregulated at both the messenger RNA (mRNA) and protein levels in a d...
Source: Inflammation - June 12, 2015 Category: Allergy & Immunology Source Type: research

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Publication date: Available online 17 May 2015 Source:Genomics Data Author(s): S.T. Nurnberg , K. Cheng , A. Raiesdana , R. Kundu , C.L. Miller , J.B. Kim , K. Arora , I. Carcamo-Oribe , Y. Xiong , N. Tellakula , V. Nanda , N. Murthy , W.A. Boisvert , U. Hedin , L. Perisic , S. Aldi , L. Maegdefessel , M. Pjanic , G.K. Owens , M.D. Tallquist , T. Quertermous TCF21 is a basic helix-loop-helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major dis...
Source: Genomics Data - May 17, 2015 Category: Genetics & Stem Cells Source Type: research

A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway
Conclusions and ImplicationsIDHP attenuated the cardiac fibrosis induced by isoprenaline through a NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis, induced by β‐adrenoceptor agonists.
Source: British Journal of Pharmacology - May 5, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: RESEARCH PAPER Source Type: research

Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells.
CONCLUSION: Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype. PMID: 25913202 [PubMed - as supplied by publisher]
Source: Differentiation - April 23, 2015 Category: Research Authors: Ikhapoh IA, Pelham CJ, Agrawal DK Tags: Differentiation Source Type: research

GSE44461 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Contributors : Sylvia T Nurnberg ; Karen Cheng ; Azad Raiesdana ; Ramendra Kundu ; Clint L Miller ; Juyong B Kim ; Komal Arora ; Ivan Carcamo-Oribe ; Yiqin Xiong ; Nikhil Tellakula ; Vivek Nanda ; Nikitha Murthy ; William A Boisvert ; Ulf Hedin ; Ljubica Perisic ; Silvia Aldi ; Lars Maegdefessel ; Milos Pjanic ; Gary K Owens ; Michelle D Tallquist ; Thomas QuertermousSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-...
Source: GEO: Gene Expression Omnibus - March 19, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

IDHP Attenuates β‐Adrenergic Receptor Mediated Cardiac Fibrosis depending on NOX2/ROS/p38 Pathway
CONCLUSIONS AND IMPLICATIONSIDHP attenuates cardiac fibrosis induced by isoproterenol through NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis.
Source: British Journal of Pharmacology - March 13, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed issue Source Type: research

Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms
This study was designed to investigate the effects of VNP on ischemia-reperfusion injury in diabetic rats and to further elucidate its mechanisms. The high-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats were subjected to ischemia-reperfusion operation. VNP treatment (100 μg/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Moreover, VNP inhib...
Source: AJP: Heart and Circulatory Physiology - February 15, 2015 Category: Cardiology Authors: Shi, Z., Fu, F., Yu, L., Xing, W., Su, F., Liang, X., Tie, R., Ji, L., Zhu, M., Yu, J., Zhang, H. Tags: CALL FOR PAPERS Source Type: research

Development of Lipoprotein(a) siRNAs for Mechanism of Action Studies in Non-Human Primate Models of Atherosclerosis
We describe targeting of LPA using lipid nanoparticle formulated short interfering RNAs (siRNAs) in lean rhesus macaque monkeys. We show >90 % LPA mRNA lowering in the liver and >95 % Lp(a) plasma reduction for over 3 weeks after a single siRNA dose. Given the potency of LPA siRNAs, siRNA approach may enable chronic reduction of Lp(a) in atherosclerotic NHP and help to unmask the role for Lp(a) in the genesis and progression of atherosclerosis in man.
Source: Journal of Cardiovascular Translational Research - January 21, 2015 Category: Cardiology Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Vasonatrin peptide attenuates myocardial ischemia/reperfusion injury in diabetic rats and underlying mechanisms.
Conclusions: VNP protects diabetic heart against ischemia/reperfusion injury by inhibiting ER stress via cGMP-PKG signaling pathway. These results suggest that VNP may have potential therapeutic value for the diabetic patients with ischemic heart disease. PMID: 25485902 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 5, 2014 Category: Physiology Authors: Shi Z, Fu F, Yu L, Xing W, Ji L, Tie R, Liang X, Zhu M, Yu J, Zhang H Tags: Am J Physiol Heart Circ Physiol Source Type: research

Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function Coronary Heart Disease
Conclusions Our data implicate that heparan sulfate elongation genes EXT1 and EXT2 are involved in maintaining endothelial homeostasis, presumably via increased nitric oxide bioavailability.
Source: JAHA:Journal of the American Heart Association - December 2, 2014 Category: Cardiology Authors: Mooij, H. L., Cabrales, P., Bernelot Moens, S. J., Xu, D., Udayappan, S. D., Tsai, A. G., van der Sande, M. A. J., de Groot, E., Intaglietta, M., Kastelein, J. J. P., Dallinga-Thie, G. M., Esko, J. D., Stroes, E. S., Nieuwdorp, M. Tags: Coronary Heart Disease Source Type: research

miRNA, Inflammation and Coronary Heart Disease
This study demonstrates the relationship between miR-21 and the STAT3 pathway in Coronary Heart Disease. Delivering inhibitory miRNA into cardiomyocytes was key to establishing this relationship. Further study could enable discovery of STAT3 related targets for CV protective drug. In the spirit of helping researchers find the best solutions and protocols for Gene Expression Analysis Studies, we will continue to post new findings.
Source: siRNA and DsiRNA Transfection Efficiency - August 28, 2014 Category: Neuroscience Tags: cardiovascular disease Coronary Heart Disease i-Fect miRNA Delivery Methods STAT3 Transfection Source Type: news

Bone Morphogenetic Protein‐10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein‐10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. After stimulation with the recombinant BMP10, an obvious dose‐dependent cardiomyocyte proliferation and reentry of differentiated mammalian cardiomyocytes into the cell cycle was observed. Furthermore, BMP10 stimulation strikingly enhanced Tbx20 expression. Fu...
Source: Journal of Cellular Biochemistry - June 6, 2014 Category: Biochemistry Authors: Lijun Sun, Jing Yu, Shun Qi, Yuewen Hao, Ying Liu, Zhenwu Li Tags: Article Source Type: research