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Condition: Heart Disease
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Total 126 results found since Jan 2013.
The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging therapeutic targets
Biomed Pharmacother. 2023 Jun 29;165:115067. doi: 10.1016/j.biopha.2023.115067. Online ahead of print.ABSTRACTNoncoding ribonucleic acids (ncRNAs) are a class of ribonucleic acids (RNAs) that carry cellular information and perform essential functions. This class encompasses various RNAs, such as small nuclear ribonucleic acids (snRNA), small interfering ribonucleic acids (siRNA) and many other kinds of RNA. Of these, circular ribonucleic acids (circRNAs) and long noncoding ribonucleic acids (lncRNAs) are two types of ncRNAs that regulate crucial physiological and pathological processes, including binding, in several organs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Huilei Zhao Ziqi Tan Jin Zhou Yifan Wu Qingwen Hu Qing Ling Jitao Ling Menglu Liu Jianyong Ma Deju Zhang Yue Wang Jing Zhang Peng Yu Yuan Jiang Xiao Liu Source Type: research
BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun,
Junwei Liu,
Yanzheng Wang,
Hongmei Yang,
Danfeng Song,
Haiyan Fu,
Xingxing Feng Tags: Original Article Source Type: research
HAND1 knockdown disrupts trophoblast global gene expression
In this study, we aimed to build upon this knowledge and characterize the mechanistic impacts of disruptingHAND1 on human placenta trophoblast and vascular endothelial cell gene expression.HAND1 gene expression was silenced in BeWo cells, a choriocarcinoma model of human cytotrophoblasts, (n = 3–9 passages) and isolated human placental microvascular endothelial cells (HPMVEC;n = 3 passages), withHAND1 siRNA for 96 h. Cells were harvested, mRNA isolated and RNA sequencing performed using the Illumina NextSeq 550 platform. Normalization and differential gene expression analyses were conducted using general linear mo...
Source: Physiological Reports - January 25, 2023 Category: Physiology Authors: Robert Fresch,
Jennifer Courtney,
Heather Brockway,
Rebecca L. Wilson,
Helen Jones Tags: ORIGINAL ARTICLE Source Type: research
HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R
Cell Stress Chaperones. 2022 Jul 16. doi: 10.1007/s12192-022-01290-0. Online ahead of print.ABSTRACTHypoxia/reoxygenation (H/R) is used as an in vivo model of ischemia/reperfusion injury, and myocardial ischemia can lead to heart disease. Calcium overload is an important factor in myocardial ischemia-reperfusion injury and can lead to apoptosis of myocardial cells. Therefore, it is of great clinical importance to find ways to regulate calcium overload and reduce apoptosis of myocardial cells, and thus alleviate myocardial ischemia-reperfusion injury. There is evidence that heat shock protein 70 (HSP70) has a protective eff...
Source: Cell Stress and Chaperones - July 16, 2022 Category: Cytology Authors: TianYu Liu Zhaodong Juan Bin Xia GuanHua Ren Zhen Xi JunWen Hao ZhongDong Sun Source Type: research
