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Condition: Heart Disease
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Total 126 results found since Jan 2013.
HSP70 protects H9C2 cells from hypoxia and reoxygenation injury through STIM1/IP3R
Cell Stress Chaperones. 2022 Jul 16. doi: 10.1007/s12192-022-01290-0. Online ahead of print.ABSTRACTHypoxia/reoxygenation (H/R) is used as an in vivo model of ischemia/reperfusion injury, and myocardial ischemia can lead to heart disease. Calcium overload is an important factor in myocardial ischemia-reperfusion injury and can lead to apoptosis of myocardial cells. Therefore, it is of great clinical importance to find ways to regulate calcium overload and reduce apoptosis of myocardial cells, and thus alleviate myocardial ischemia-reperfusion injury. There is evidence that heat shock protein 70 (HSP70) has a protective eff...
Source: Cell Stress and Chaperones - July 16, 2022 Category: Cytology Authors: TianYu Liu Zhaodong Juan Bin Xia GuanHua Ren Zhen Xi JunWen Hao ZhongDong Sun Source Type: research
Penehyclidine hydrochloride protects Rat cardiomyocytes from ischemia-reperfusion injury by platelet-derived growth factor-B
CONCLUSION: PHC pretreatment can protect cardiomyocytes from the decrease of cell activity and the increase of apoptosis caused by reperfusion through up-regulating PDGF-B to activate PI3K pathway. Our study indicates that PHC is a potential drug to protect cells from reperfusion injury and PDGF-B is a potential target for preventing MI-R injury.PMID:35838232 | DOI:10.2174/1386207325666220715090505
Source: Combinatorial Chemistry and High Throughput Screening - July 15, 2022 Category: Chemistry Authors: Yan Lu Congna Zi Liang Zhang Boqun Cui Ling Li Jun Ma Source Type: research
GSE207658 Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome
Contributors : Georg Vogler ; Alexandre R ColasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identified. Postulating that impaired cardiomyocyte proliferation as a likely important contributing mechanism to HLHS pathogenesis, and we conducted a genome-wide siRNA screen to identify genes affecting proliferation of human iPSC-derived cardiomyocy...
Source: GEO: Gene Expression Omnibus - July 14, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
