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Condition: Coronary Heart Disease
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Total 20 results found since Jan 2013.

The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging  therapeutic targets
Biomed Pharmacother. 2023 Jun 29;165:115067. doi: 10.1016/j.biopha.2023.115067. Online ahead of print.ABSTRACTNoncoding ribonucleic acids (ncRNAs) are a class of ribonucleic acids (RNAs) that carry cellular information and perform essential functions. This class encompasses various RNAs, such as small nuclear ribonucleic acids (snRNA), small interfering ribonucleic acids (siRNA) and many other kinds of RNA. Of these, circular ribonucleic acids (circRNAs) and long noncoding ribonucleic acids (lncRNAs) are two types of ncRNAs that regulate crucial physiological and pathological processes, including binding, in several organs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Huilei Zhao Ziqi Tan Jin Zhou Yifan Wu Qingwen Hu Qing Ling Jitao Ling Menglu Liu Jianyong Ma Deju Zhang Yue Wang Jing Zhang Peng Yu Yuan Jiang Xiao Liu Source Type: research

BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun, Junwei Liu, Yanzheng Wang, Hongmei Yang, Danfeng Song, Haiyan Fu, Xingxing Feng Tags: Original Article Source Type: research

miR-17 regulates the proliferation and apoptosis of endothelial cells in coronary heart disease via targeting insulin-like-growth factor 1
Publication date: Available online 20 June 2019Source: Pathology - Research and PracticeAuthor(s): Zhongpu Chen, Xiaodong Pan, Zulong Sheng, Gaoliang Yan, Long Chen, Genshan MaAbstractCoronary heart disease (CHD) is one of the main risks of death, which is mainly caused by coronary arteries arteriosclerosis. The present study aims to investigate the potential roles of miR-17 in CHD. In the present study, Human umbilical vascular endothelial cells (HUVECs) were treated with oxidized low density lipoprotein (ox-LDL). qRT-PCR and western blot were used to examine the mRNA and protein levels, respectively. CCK-8 and flow cytom...
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

FGF21 as Modulator of Metabolism in Health and Disease
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Mechanisms of Niemann Pick type C1 Like 1 Protein Degradation in Intestinal Epithelial Cells.
In conclusion, our results showed that basal level of intestinal cholesterol transporter NPC1L1 protein is modulated by both ubiquitin-proteasome and lysosome-dependent degradation as well as by ERK1/2-dependent pathway. The modulation of these pathways may provide novel clues for therapeutic intervention to inhibit cholesterol absorption and lower plasma cholesterol. PMID: 30789754 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - February 21, 2019 Category: Cytology Authors: Malhotra P, Soni V, Yamanashi Y, Takada T, Suzuki H, Gill RK, Saksena S, Dudeja PK, Alrefai WA Tags: Am J Physiol Cell Physiol Source Type: research

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF ‑R.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R. Int J Mol Med. 2018 Mar 09;: Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Abstract The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac f...
Source: International Journal of Molecular Medicine - March 9, 2018 Category: Molecular Biology Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Tags: Int J Mol Med Source Type: research

MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
CONCLUSIONS: These results indicate that circulating miR-15b-5p is a suitable biomarker for discriminating between patients with well-developed or poorly developed collaterals. Moreover, miR-15b-5p is a key regulator of arteriogenesis and angiogenesis, which may represent a potential therapeutic target for ischemic disease. PMID: 28254819 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 1, 2017 Category: Cardiology Authors: Zhu LP, Zhou JP, Zhang JX, Wang JY, Wang ZY, Pan M, Li LF, Li CC, Wang KK, Bai YP, Zhang GG Tags: Arterioscler Thromb Vasc Biol Source Type: research

H2 S inhibits apo(a) expression and secretion through PKCα/FXR and Akt/HNF4α pathways in HepG2 cells.
This study reveals that H2 S suppressed apo(a) expression and secretion via the PKCα-FXR and PI3K/Akt-HNF4α pathways. PMID: 27298021 [PubMed - as supplied by publisher]
Source: Cell Biology International - June 13, 2016 Category: Cytology Authors: Qu K, Liu YM, He XL, Zhang H, Zhang K, Peng J, Tang YL, Yu XH, Zeng JF, Lei JJ, Wei DH, Wang Z Tags: Cell Biol Int Source Type: research

Ox-LDL Upregulates IL-6 Expression by Enhancing NF-κB in an IGF2-Dependent Manner in THP-1 Macrophages
Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that is well established as a vital factor in determining the risk of coronary heart disease and pathogenesis of atherosclerosis. Moreover, accumulating evidences have shown that oxidized low-density lipoprotein (ox-LDL) can promote IL-6 expression in macrophages. Nevertheless, the underlying mechanism of how ox-LDL upregulates IL-6 expression remains largely unexplained. We found that the expression of insulin-like growth factor 2 (IGF2), nuclear factor kappa B (NF-κB), and IL-6 was upregulated at both the messenger RNA (mRNA) and protein levels in a d...
Source: Inflammation - June 12, 2015 Category: Allergy & Immunology Source Type: research

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Publication date: Available online 17 May 2015 Source:Genomics Data Author(s): S.T. Nurnberg , K. Cheng , A. Raiesdana , R. Kundu , C.L. Miller , J.B. Kim , K. Arora , I. Carcamo-Oribe , Y. Xiong , N. Tellakula , V. Nanda , N. Murthy , W.A. Boisvert , U. Hedin , L. Perisic , S. Aldi , L. Maegdefessel , M. Pjanic , G.K. Owens , M.D. Tallquist , T. Quertermous TCF21 is a basic helix-loop-helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major dis...
Source: Genomics Data - May 17, 2015 Category: Genetics & Stem Cells Source Type: research

GSE44461 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Contributors : Sylvia T Nurnberg ; Karen Cheng ; Azad Raiesdana ; Ramendra Kundu ; Clint L Miller ; Juyong B Kim ; Komal Arora ; Ivan Carcamo-Oribe ; Yiqin Xiong ; Nikhil Tellakula ; Vivek Nanda ; Nikitha Murthy ; William A Boisvert ; Ulf Hedin ; Ljubica Perisic ; Silvia Aldi ; Lars Maegdefessel ; Milos Pjanic ; Gary K Owens ; Michelle D Tallquist ; Thomas QuertermousSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-...
Source: GEO: Gene Expression Omnibus - March 19, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

IDHP Attenuates β‐Adrenergic Receptor Mediated Cardiac Fibrosis depending on NOX2/ROS/p38 Pathway
CONCLUSIONS AND IMPLICATIONSIDHP attenuates cardiac fibrosis induced by isoproterenol through NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis.
Source: British Journal of Pharmacology - March 13, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed issue Source Type: research

Development of Lipoprotein(a) siRNAs for Mechanism of Action Studies in Non-Human Primate Models of Atherosclerosis
We describe targeting of LPA using lipid nanoparticle formulated short interfering RNAs (siRNAs) in lean rhesus macaque monkeys. We show >90 % LPA mRNA lowering in the liver and >95 % Lp(a) plasma reduction for over 3 weeks after a single siRNA dose. Given the potency of LPA siRNAs, siRNA approach may enable chronic reduction of Lp(a) in atherosclerotic NHP and help to unmask the role for Lp(a) in the genesis and progression of atherosclerosis in man.
Source: Journal of Cardiovascular Translational Research - January 21, 2015 Category: Cardiology Source Type: research