Mechanisms of Niemann Pick type C1 Like 1 Protein Degradation in Intestinal Epithelial Cells.

In conclusion, our results showed that basal level of intestinal cholesterol transporter NPC1L1 protein is modulated by both ubiquitin-proteasome and lysosome-dependent degradation as well as by ERK1/2-dependent pathway. The modulation of these pathways may provide novel clues for therapeutic intervention to inhibit cholesterol absorption and lower plasma cholesterol.
PMID: 30789754 [PubMed - as supplied by publisher]

Source: Am J Physiol Cell Ph... - February 21, 2019 Category: Cytology Authors: Malhotra P, Soni V, Yamanashi Y, Takada T, Suzuki H, Gill RK, Saksena S, Dudeja PK, Alrefai WA Tags: Am J Physiol Cell Physiol Source Type: research