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Cancer: Lung Cancer
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Total 1667 results found since Jan 2013.
GSE234780 Knockdown TIMM13 in A549 lung cancer cell line
Contributors : Zhaozhao Zhao ; Ting NiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe depleted TIMM13 using short interfering RNA (siRNA) in A549 lung cancer cells, and found that silencing of TIMM13 could significantly inhibit A549 cell proliferation. Thus, we conducted RNA-seq in the A549 cells transduced with either nontargeting siRNA or two distinct TIMM13-specific siRNAs. We observed widespread gene expression change in A549 cells upon TIMM13 knockdown.
Source: GEO: Gene Expression Omnibus - June 17, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Harmine loaded Au@MSNs@PEG@Asp6 nano-composites for treatment of spinal metastasis from lung adenocarcinoma by targeting ANXA9 < em > in vivo < /em > experiment
CONCLUSIONS: ANXA9 may serve as a novel biomarker for predicting poor prognosis in LUAD, and we provided an efficient and targeting drug delivery nano-composites system for precise treatment of SM from LUAD.PMID:37323183 | PMC:PMC10261857 | DOI:10.21037/tlcr-23-191
Source: Cell Research - June 16, 2023 Category: Cytology Authors: Houlei Wang Fancheng Chen Annan Hu Haifeng Liang Yun Liang Nagashree Seetharamu Huiren Wang Jian Dong Source Type: research
GSE222598 Effect of SF3B4 depletion on gene expression of A549 lung cancer cell
Contributor : Tao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function SF3B4 during the progression of lung cancer, A549 cells with either SF3B4 siRNA or scramble siRNA were used for RNA-seq.
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs
Arch Biochem Biophys. 2023 May 12:109637. doi: 10.1016/j.abb.2023.109637. Online ahead of print.ABSTRACTAlthough it is widely reported that Pokemon acts as an oncogene in the pathogenesis of multiple cancers, but its role and detailed molecular mechanisms in regulating non-small cell lung cancer (NSCLC) progression have not been fully delineated. Here, by performing Real-Time qPCR analysis, we verified that Pokemon was high-expressed in NSCLC tissues and cells, compared to the corresponding normal lung tissues and epithelial cells. Then, the small interfering RNA (siRNA) for Pokemon was transfected into the NSCLC cells to ...
Source: Archives of Biochemistry and Biophysics - May 14, 2023 Category: Biochemistry Authors: Hao Chang Wenxue Sun Yiming Zhao Tianhao Sun Zhihong Zhao Source Type: research
Targeting transient receptor potential canonical 1 reduces non ‑small cell lung cancer chemoresistance and stemness via inhibition of PI3K/AKT signaling
In conclusion, the results of the current study suggested that targeting TRPC1 could attenuate cancer stemness and chemoresistance via suppression of PI3K/AKT signaling in NSCLC.PMID:37153044 | PMC:PMC10157351 | DOI:10.3892/ol.2023.13810
Source: Oncology Letters - May 8, 2023 Category: Cancer & Oncology Authors: Jiahui Jin Xinyu Yan Yaru Zhao Haojie Zhang Kai Zhuang Yating Wen Jingjing He Junzhen Gao Source Type: research
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
CONCLUSIONS: Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.PMID:37150829 | DOI:10.1186/s13046-023-02674-5
Source: Clinical Lung Cancer - May 7, 2023 Category: Cancer & Oncology Authors: Boting Ning Andrew M Tilston-Lunel Justice Simonetti Julia Hicks-Berthet Adeline Matschulat Roxana Pfefferkorn Avrum Spira Matthew Edwards Sarah Mazzilli Marc E Lenburg Jennifer E Beane Xaralabos Varelas Source Type: research
Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells
Appl Biochem Biotechnol. 2023 Apr 27. doi: 10.1007/s12010-023-04507-9. Online ahead of print.ABSTRACTThe non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. It is usually diagnosed at an advanced stage with poor prognosis. Nimbolide (NB), a terpenoid limonoid isolated from the flowers and leaves of neem tree, possesses anticancer properties in various cancer cell lines. However, the underlying mechanism of its anticancer effect on human NSCLC cells remains unclear. In the present study, we investigated the effect of NB on A549 human NSCLC cells. We found that NB treatment inhibits A549 cells colo...
Source: Applied Biochemistry and Biotechnology - April 27, 2023 Category: Biochemistry Authors: Xi Chen Hangshuo Zhang Yuzhu Pan Ning Zhu Lisha Zhou Guang Chen Jiabing Wang Source Type: research
Selective CDK9 knockdown sensitizes TRAIL response by suppression of antiapoptotic factors and NF-kappaB pathway
AbstractThe aberrantly up-regulated CDK9 can be targeted for cancer therapy. The CDK inhibitor dinaciclib (Dina) has been found to drastically sensitizes cancer response to TRAIL-expressing extracellular vesicle (EV-T). However, the low selectivity of Dina has limited its application for cancer. We propose that CDK9-targeted siRNA (siCDK9) may be a good alternative to Dina. The siCDK9 molecules were encapsulated into EV-Ts to prepare a complexed nanodrug (siEV-T). It was shown to efficiently suppress CDK9 expression and overcome TRAIL resistance to induce strikingly augmented apoptosis in lung cancer both in vitro and in v...
Source: Apoptosis - April 15, 2023 Category: Molecular Biology Source Type: research
