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Cancer: Lung Cancer
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Total 1667 results found since Jan 2013.
Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma
Clin Exp Med. 2022 Jun 21. doi: 10.1007/s10238-022-00847-8. Online ahead of print.ABSTRACTRas suppressor-1 (RSU1), originally described as a suppressor of Ras oncogenic transformation, localizes to focal adhesions interacting with the ILK-PINCH-PARVIN (IPP) complex that exerts a well-established oncogenic role in cancer. However, RSU1 implication in lung cancer is currently unknown. Our study aims to address the role of RSU1 in lung adenocarcinoma (LUADC). We here show that RSU1 protein expression by immunohistochemistry is downregulated in LUADC human tissue samples and represents a significant prognostic indicator. In si...
Source: Clinical Lung Cancer - June 21, 2022 Category: Cancer & Oncology Authors: Sofia Nikou Marina Arbi Foteinos-Ioannis D Dimitrakopoulos Argiro Kalogeropoulou Christina Geramoutsou Vasiliki Zolota Haralabos P Kalofonos Stavros Taraviras Zoi Lygerou Vasiliki Bravou Source Type: research
Amygdalin Induced Mitochondria-Mediated Apoptosis of Lung Cancer Cells via Regulating NFFormula: see textB-1/NFFormula: see textB Signaling Cascade < em > in Vitro < /em > and < em > in Vivo < /em >
Am J Chin Med. 2022 Jun 8:1-26. doi: 10.1142/S0192415X22500586. Online ahead of print.ABSTRACTLung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Amygdalin, a natural compound commonly distributed in plants of the Rosaceae species, owns anticancer activity, less side effects, wide source, and relatively low price. Although the apoptosis is a central process activated by amygdalin in cancer cells, the underlying molecular mechanisms through which amygdalin induces the apoptosis of lung cancer cells remain poorly understood. In this research work, amygdalin could suppress the pr...
Source: The American Journal of Chinese Medicine - June 10, 2022 Category: Complementary Medicine Authors: Shumeng Lin Jing Wen Xiao Xu Jiamin Shi Wen Zhang Tiansheng Zheng Yaqin Hou Yanfei Zhang Ziye Li Kai Wang Jing Jin Liduo Yue Baigenzhin Abay Ming Li Qingxi Yue Lihong Fan Source Type: research
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line
This study aimed to investigate the pathophysiological functions of ET-2 in A549 human lung adenocarcinoma cells. We analyzed the expression of ET-2 mRNA in lung adenocarcinoma tissues compared to that in non-tumor lung tissues using public online databases. The function of ET-2 in A549 cells was investigated using siRNA. ET-2 mRNA level was upregulated in lung adenocarcinoma tissues, and high ET-2 level was associated with poor overall survival in patients with lung adenocarcinoma. ET-2 silencing reduced the proliferation, migration, invasion, and enhanced apoptosis in A549 cells. Mechanistically, ET-2 silencing reduced t...
Source: Canadian Journal of Physiology and Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Ratih Paramita Suprapto Yoko Suzuki Tatsuya Nagano Ken-Ichi Hirata Noriaki Emoto Source Type: research
