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Condition: Alcoholism
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Total 50966 results found since Jan 2013.
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury
CONCLUSIONS: Taken together, Fgl2 hastens the development of alcoholic liver injury by mediating PKM2 dependent aerobic glycolysis in proinflammatory macrophages. Strategies that inhibiting proinflammatory macrophage activation by silencing Fgl2 might be a potential therapeutic intervention for alcoholic liver injury.PMID:37734200 | DOI:10.1016/j.intimp.2023.110957
Source: International Immunopharmacology - September 21, 2023 Category: Allergy & Immunology Authors: Xue Hu Xiaoyang Wan Yuting Diao Zhe Shen Zhongwei Zhang Peng Wang Danqin Hu Xiaojing Wang Weiming Yan Chaohui Yu Xiaoping Luo Hongwu Wang Qin Ning Source Type: research
Tough, recyclable and biocompatible carrageenan-modified polyvinyl alcohol ionic hydrogel with physical cross-linked for multimodal sensing
Int J Biol Macromol. 2023 Sep 19:126954. doi: 10.1016/j.ijbiomac.2023.126954. Online ahead of print.ABSTRACTBiocompatibility hydrogel conductors are considered as sustainable bio-electronic materials for the application of wearable sensors and implantable devices. However, they mostly face the limitations of mismatched mechanical properties with skin tissue and the difficulty of recycling. In this regard, here, a biocompatible, tough, reusable sensor based on physical crosslinked polyvinyl alcohol (PVA) ionic hydrogel modified with ι-carrageenan (ι-CG) helical network was reported. Through simulating the ion transport an...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Lingjun Zeng Bo Liu Lijie Duan Guanghui Gao Source Type: research
Modeling and investigation of swelling kinetics of sodium carboxymethyl cellulose/starch/citric acid superabsorbent polymer
Int J Biol Macromol. 2023 Sep 19:127013. doi: 10.1016/j.ijbiomac.2023.127013. Online ahead of print.ABSTRACTCrosslinked hydrophilic polymers with high water absorption rates are known as superabsorbent polymers (SAPs). Most commercial superabsorbent polymers are made with acrylic acid, which is difficult to biodegrade. So, in this investigation, carboxymethyl cellulose (CMC) was utilized as a significant component in the synthesis of polysaccharide-based SAPs. Citric acid (CA) and starch were chosen as crosslinking agents because they are more eco-friendly, non-toxic, and biodegradable than traditional crosslinking agents....
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Cheera Prasad Seo Young Park Jai Sung Lee Jae Jun Park Yeonju Jang Sung Woo Lee Byoung-Min Lee You-Ree Nam A Karteek Rao Hyeong Yeol Choi Source Type: research
Are you thinking what I'm thinking? Defining what we mean by "polysubstance use."
Am J Drug Alcohol Abuse. 2023 Sep 21:1-7. doi: 10.1080/00952990.2023.2248360. Online ahead of print.ABSTRACTThe rise in drug overdoses and harms associated with the use of more than one substance has led to increased use of the term "polysubstance use" among researchers, clinicians, and public health officials. However, the term retains no consistent definition across contexts. The current authors convened from disciplines including sociology, epidemiology, neuroscience, and addiction psychiatry to propose a recommended definition of polysubstance use. An iterative process considered authors' formal and informal conversati...
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Amanda M Bunting Riley Shearer Ashley N Linden-Carmichael Arthur Robin Williams Sandra D Comer Magdalena Cerd á Jennifer Lorvick Source Type: research
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico
Conclusions: Data suggest combined ibogaine and 5-MeO-DMT assisted therapy has potential to provide rapid and robust changes in mental health functioning with a signal of durable therapeutic effects up to 6-months. Future research in controlled settings is warranted.PMID:37734158 | DOI:10.1080/00952990.2023.2220874
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Alan Kooi Davis Yitong Xin Nathan Sepeda Lynnette A Averill Source Type: research
Tripping outside the lines: lessons from observational studies of combination psychedelic use beyond regulated clinical contexts
Am J Drug Alcohol Abuse. 2023 Sep 21:1-5. doi: 10.1080/00952990.2023.2246637. Online ahead of print.NO ABSTRACTPMID:37734058 | DOI:10.1080/00952990.2023.2246637
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Sarah Kratina Leah M Mayo Source Type: research
Differing time trends for alcohol misuse and alcohol use disorder among Veteran men: A comparison of population surveillance and clinical data
CONCLUSIONS: Increasing trends in AUD diagnoses among VA patients are a contrast to the decreasing trends in unhealthy alcohol use and AUD population prevalence among male US veterans. However, differences in trends by age group highlights a need to better understand the process of clinical AUD identification, particularly for younger men.PMID:37734285 | DOI:10.1016/j.addbeh.2023.107862
Source: Addictive Behaviors - September 21, 2023 Category: Addiction Authors: Katherine J Hoggatt Neetu Chawla Elizabeth M Yano Source Type: research
Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice
CONCLUSIONS: RYGB improved whole-body composition and hepatic lipid homeostasis to a greater extent than CR in mice. RYGB was associated with discrete remodeling of the hepatic transcriptome, suggesting that surgery may be mechanistically additive to CR.PMID:37731222 | DOI:10.1002/oby.23876
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Christopher L Axelrod Ingeborg Langohr Wagner S Dantas Elizabeth C Heintz Bolormaa Vandanmagsar Shengping Yang Elizabeth R M Zunica R Leigh Townsend Vance L Albaugh Hans-Rudolf Berthoud John P Kirwan Source Type: research
Causal relationship between addictive behaviors and epilepsy risk: A mendelian randomization study
CONCLUSION: This MR study indicated a potential genetically predicted causal association between lifetime cannabis use and higher risk of epilepsy. As for the other four addictive behaviors, no evidence of a causal relationship with the risk of epilepsy was found in this study.PMID:37729683 | DOI:10.1016/j.yebeh.2023.109443
Source: Epilepsy and Behaviour - September 20, 2023 Category: Neurology Authors: Zhen Liang Lin Qiu Yingyue Lou Zhaoshi Zheng Qi Guo Qing Zhao Songyan Liu Source Type: research
Structural and histochemical aspects of the Gymnotus carapo tegument (Teleostei: Gymnotiformes)
An Acad Bras Cienc. 2023 Sep 18;95(4):e20191259. doi: 10.1590/0001-3765202320191259. eCollection 2023.ABSTRACTThe present study aims to structurally and histochemically characterize the Gymnotus carapo tegument. 30 specimens were captured and slaughtered by spinal section with anesthesia. The observation was carried out with a stereoscopic microscope and the body surface was photographed. Fragments of the dorsal, ventral and lateral region were fixed in Bouin's solution for 12 hours and subsequently preserved in 70% alcohol. They were subsequently observed in the scanning electron microscope (SEM). The preparation for SEM ...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Tania Blanco Cohene Gabriela Olea Carolina Flores Quintana Source Type: research
Cancer Prevention and Early Detection: A Changing Field With an Unchanging Goal
Clin J Oncol Nurs. 2023 Sep 15;27(5):457-458. doi: 10.1188/23.CJON.457-458.ABSTRACTModifiable risk factors such as tobacco and alcohol use, obesity, sun exposure, and infections account for 40%-50% of all new cancer diagnoses and all cancer deaths in the United States (American Cancer Society [ACS], 2023).PMID:37729455 | DOI:10.1188/23.CJON.457-458
Source: Clinical Journal of Oncology Nursing - September 20, 2023 Category: Nursing Authors: Joni Watson Source Type: research
Healthy lifestyle promotion via digital self-help for mental health patients in primary care: a pilot study including an embedded randomized recruitment trial
CONCLUSIONS: Recruitment routines seemed to be decisive for reaching as many patients as possible. The relatively low rate of unhealthy lifestyle behaviors and small effect sizes suggests that the intervention may only suit patients at risk.TRIAL REGISTRATION: ClinicalTrials.gov NCT03691116 (01/10/2018), focusing on the embedded trial. Retrospectively registered for the first clinic and prospectively for the second clinic.PMID:37728142 | DOI:10.1017/S146342362300049X
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Karoline Kolaas Erland Axelsson Erik Hedman-Lagerl öf Anne H Berman Source Type: research
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
