Filtered By:
Nutrition: Vitamins

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 92 results found since Jan 2013.

GSE129811 The effect of an NAD+ precursor vitamin B3, niacin, on muscle transcriptomic profiles of mitochondrial myopathy patients and healthy controls
Conclusions: These results showed that niacin modulated the expression of disease associated pathways and suppressed mTOR signalling in patients but niacin did not affect disease-related ISRmt signalling.
Source: GEO: Gene Expression Omnibus - September 17, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Recent progress in Gene Therapy and Other Targeted Therapeutic Approaches for Beta Thalassemia.
Abstract Thalassemia syndromes are a group of inherited blood disorders caused by limitation or absence of alpha or beta- globin chain synthesis resulting in ineffective erythropoiesis and chronic hemolytic anemia. According to the clinical fact of thalassemia as recessive autosomal, thalassemia divided into alpha and beta thalassemia. The main complication of beta thalassemia is excessive red blood cells destruction, oxidative stress, extramedullary hematopoiesis pseudotumors, hemosiderosis-induced organ dysfunction, malignancy, polyneuropathy, myopathy, osteoporosis, and leg ulcers. Although, the first obligator...
Source: Current Drug Targets - July 25, 2019 Category: Drugs & Pharmacology Authors: Hamed EM, Meabed MH, Aly UF, Hussein RRS Tags: Curr Drug Targets Source Type: research

Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain.
Conclusion: We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS. PMID: 31019583 [PubMed - in process]
Source: Disease Markers - April 26, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Cardiovascular Health in Children and Adolescents With Congenital Adrenal Hyperplasia Due to 21-Hydroxilase Deficiency
Conclusions Increasing evidence indicates that CAH individuals are prone to develop a number of early CV risk factors, such as obesity, hypertension, insulin resistance, low-grade inflammation, increased IMT and subclinical cardiac dysfunction, already in childhood. The therapeutic management of patients with CAH remains a challenge and current treatment regimens do not always allow optimal biochemical control. Overexposure to glucocorticoids and mineralocorticoids as well as to androgens may contribute to the development of unfavorable metabolic and CV changes, even though metabolic derangement in CAH patients may also ...
Source: Frontiers in Endocrinology - April 10, 2019 Category: Endocrinology Source Type: research

Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis
We present the case of a patient with long-term idiopathic hyperCKemia who, after contracting an upper respiratory tract infection, developed severe rhabdomyolysis and acute kidney injury. Upon hemodialysis, his renal function recovered and CK levels fell to below baseline, and maintenance therapy with vitamin B6 was also started. A molecular diagnosis of McArdle disease was subsequently made. Whole-exome sequencing revealed homozygous c1538delG (p.Asp511Thr fs*28) mutations in the PYGM gene, which was a novel mutation. Therefore, when investigating idiopathic hyperCKemia, glycogen storage disorders should also be considered.
Source: CEN Case Reports - March 20, 2019 Category: Urology & Nephrology Source Type: research

A descriptive pilot study of mitochondrial mutations & clinical phenotype in fibromyalgia syndrome.
A descriptive pilot study of mitochondrial mutations & clinical phenotype in fibromyalgia syndrome. Indian J Med Res. 2019 Jan;149(1):47-50 Authors: Danda S, Thomas BM, Paramasivam G, Thomas R, Mathew J, Danda D Abstract Background & objectives: : Fibromyalgia syndrome (FMS) is one of the most common chronic pain conditions of unknown aetiology. Mitochondrial dysfunction has been reported in FMS with some studies reporting the presence of mitochondrial mutation namely A3243G, which also causes mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes. This pilot study was condu...
Source: Indian J Med Res - December 31, 2018 Category: Research Authors: Danda S, Thomas BM, Paramasivam G, Thomas R, Mathew J, Danda D Tags: Indian J Med Res Source Type: research

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.
Authors: Hamed SA Abstract INTRODUCTION: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Areas covered: This review summarized central and peripheral nervous system complications of uremic syndrome of CKD and their pathogenic mechanisms. They include cognitive deterioration, encephalopathy, seizures, asterixis, myoclonus, restless leg syndrome, central pontine mye...
Source: Expert Review of Clinical Pharmacology - December 7, 2018 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Diagnosis and Treatment of Mitochondrial Myopathies
AbstractMitochondrial myopathies are progressive muscle conditions caused primarily by the impairment of oxidative phosphorylation (OXPHOS) in the mitochondria. This causes a deficit in energy production in the form of adenosine triphosphate (ATP), particularly in skeletal muscle. The diagnosis of mitochondrial myopathy is reliant on the combination of numerous techniques including traditional histochemical, immunohistochemical, and biochemical testing combined with the fast-emerging molecular genetic techniques, namely next-generation sequencing (NGS). This has allowed for the diagnosis to become more effective in terms o...
Source: Neurotherapeutics - November 7, 2018 Category: Neurology Source Type: research

Dietary Supplements and Cardiovascular Diseases
The market of nutritional supplements is expected to expand over 6%/year through 2018 due to growing interest in personal health, aging population, and promising personalized care products. The most used dietary supplements are fish oil, multivitamins, Vitamin D, and coenzyme Q10 (CoQ10) in this order, while probiotics is the fastest growing supplement. In the U.S., over 68% of the population use dietary supplements regularly. On the other hand, in the developed countries, cardiovascular diseases (CVDs) are the main cause of death and morbidity from the 1900s. The effects of most dietary supplements on cardiovascular risk ...
Source: International Journal of Preventive Medicine - September 22, 2018 Category: International Medicine & Public Health Source Type: research

Severe Hypocalcemia and Extreme Elevation of Serum Creatinkinase in a 16-Year Old Boy with Pseudohypoparathyroidism Type Ib.
In conclusion, manifest tetany and even mild myopathy with very high S-CK can occur in hypocalcemic patients and usually resolves after normalization of hypocalcemia. PMID: 30216183 [PubMed - in process]
Source: Acta Medica: Hradec Kralove - September 16, 2018 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers.
This study evaluated cholecalciferol effects on the deep fibular nerve and extensor digitorum longus (EDL) muscle using an UChB ethanol-preferring rats model. Blood analyses were carried out to measure levels of 25-hydroxycholecalciferol (25(OH)D), calcium (Ca2+), Phosphorus (P), and parathyroid hormone (PTH). It was used EDL muscle to evaluate oxidative stress. The deep fibular nerve and EDL muscle were used for morphologic and morphometric assessment. 25(OH)D plasma levels were higher in the supplemented group and no alterations were observed in other parameters including the oxidative stress evaluation. The G ratio rema...
Source: Acta Histochemica - September 14, 2018 Category: Biochemistry Authors: Guidi Pinto C, Colombo Marchi K, Amarante Arizza A, Silveira Leite AP, Tirapelli CR, Michelin Matheus SM Tags: Acta Histochem Source Type: research

Post-Mortem Detection of FLAD1 Mutations in 2 Turkish Siblings with Hypotonia in Early Infancy
Vitamin B2, or riboflavin, is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as cofactors of flavoproteins, or flavoenzymes, that are involved in multiple cellular processes, including mitochondrial respiratory chain and degradation of fatty acids, some amino acids and choline, among others [1]. Inherited defects in electron tranfer flavoprotein (ETF, coded by ETFA and ETFB genes) and ETF dehydrogenase (ETFDH gene) have been shown to impair the relay of electrons from multiple mitochondrial acyl-CoA dehydrogenases to the respiratory chain, resulting in multiple acyl-CoA dehy...
Source: Neuromuscular Disorders - May 31, 2018 Category: Neurology Authors: Y ılmaz Yıldız, Rikke Katrine Jentoft Olsen, Hatice Serap Sivri, Zuhal Akçören, Helle Highland Nygaard, Ayşegül Tokatlı Tags: Case report Source Type: research

S-25OHD is Associated with Hand Grip Strength and Myopathy at Five Years in Girls: An Odense Child Cohort Study.
Conclusions: Five-year s-25OHD was independently associated with HGS and myopathy in girls, but not in boys. Muscle strength may be dependent on vitamin D status even in the higher range in preschool girls. The sex difference remains unexplained. PMID: 29788436 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 16, 2018 Category: Endocrinology Authors: Al-Jwadi RF, Jespersen E, Dalgård C, Bilenberg N, Christesen HT Tags: J Clin Endocrinol Metab Source Type: research

Effect of SLCO1B1 gene polymorphisms and vitamin D on statin-induced myopathy
Journal Name: Drug Metabolism and Personalized Therapy Issue: Ahead of print
Source: Drug Metabolism and Personalized Therapy - February 9, 2018 Category: Drugs & Pharmacology Source Type: research