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Nutrition: Vitamins

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Total 92 results found since Jan 2013.

G.P.26: Vitamin D deficiency myopathy in Egypt: A treatable myopathy
Vitamin D deficiency could be due to decreased bioavailability (decreased intake or exposure to sunlight, urinary loss or malabsorption), abnormal metabolism (liver disease, renal disease) or abnormal target tissue response (vitamin D resistant or gastrointestinal disorders). Vitamin D deficiency is one of the causes of osteomalacic myopathy. To highlight the clinical and laboratory characteristics of vitamin D deficiency myopathy in Egypt and to discuss its therapeutic implications. All patients presented with gradual progressive limb-girdle weakness with or without bony pains, pains of limb muscles, low backache or joint...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: N.A. Fahmy, D. Fayez Source Type: research

Myopathies of endocrine disorders: A prospective clinical and biochemical study
Conclusion: We found varied clinical presentations of endocrine myopathies. All the patients with neuromuscular complaints should be investigated for endocrine causes because significant number of them recovers fully with specific treatment.
Source: Annals of Indian Academy of Neurology - August 12, 2014 Category: Neurology Authors: Vikas SharmaPapori BorahLakshya J BasumataryMarami DasMunindra GoswamiAshok K Kayal Source Type: research

Low Vitamin D as a Risk Factor for the Development of Myalgia in Patients Taking High-Dose Simvastatin: A Retrospective Review.
CONCLUSION: A lower incidence of adverse muscle events with high-dose simvastatin 80 mg was found in patients with higher vitamin D levels, suggesting that correction of 25-hydroxyvitamin D levels before statin therapy initiation may mitigate one risk factor in the development of statin-related myalgia. Vitamin D insufficiency appears to be a risk factor for the development of myalgia. PMID: 24742497 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - April 14, 2014 Category: Drugs & Pharmacology Authors: Mergenhagen K, Ott M, Heckman K, Rubin LM, Kellick K Tags: Clin Ther Source Type: research

The Relationship Between Vitamin D Concentrations and Leg Strength in Persons with Parkinson's (P2.054)
CONCLUSION: Our data does not indicate that lower vitamin D levels are associated with reduced muscle strength; there were non-significant trends to suggest the opposite. These results may be spurious or there may be a different relationship in persons with PD. Mechanisms beyond strength such as central balance control, changes in gait patterns, and cognitive function are necessary to include in intervention studies of vitamin D and balance/falls.Study Supported by: Department of Veterans Affairs CDA2 Award, OCTRI - grant number UL1 RR024140; NeuroNext (5U10NS077350-02).Disclosure: Dr. Peterson has nothing to disclose. Dr....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Peterson, A., Lobb, B., Murchison, C., Quinn, J. Tags: Movement Disorders: Co-morbidities and Novel Care Models Source Type: research

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
Abstract Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD+/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease, because of inefficient NADH utilization and ATP production. Oral administration of nicotinamide riboside (NR), a vitamin B3 and NAD+ precursor, was previously shown to boost NAD+ levels in mice and to induce mi...
Source: EMBO Molecular Medicine - April 1, 2014 Category: Molecular Biology Authors: Nahid A Khan, Mari Auranen, Ilse Paetau, Eija Pirinen, Liliya Euro, Saara Forsström, Lotta Pasila, Vidya Velagapudi, Christopher J Carroll, Johan Auwerx, Anu Suomalainen Tags: Research Article Source Type: research

Myopathy related to vitamin D deficiency in patient with Celiac disease
Source: Muscle and Nerve - February 23, 2014 Category: Internal Medicine Authors: Ozgur Zeliha Karaahmet, Ece Unlu, Fatih Karaahmet, Eda Gurcay, Aytul Cakci Tags: Letter to the Editor Source Type: research

Saturated fat link with heart disease questioned
This article is one doctor's opinion based on his own knowledge, research and experience. However, it is fair to say there is an ongoing debate about how far cholesterol is a risk factor for heart disease, especially in people who are otherwise healthy. There is also a similar debate about the use of statins in people who have no evidence of cardiovascular disease. This is alongside ongoing research into the components of LDL and the different types of lipoproteins known to increase risk the most. None of this relevant new evidence is covered by the news reporting.   What should you eat? There is no need to change curren...
Source: NHS News Feed - October 23, 2013 Category: Consumer Health News Tags: Heart/lungs Food/diet QA articles Source Type: news

Vitamin D: role and opportunity to prescribe.
Abstract The major role of vitamin D in humans is to increase the absorption of calcium and phosphatase for the mineralization of the skeleton. The synthesis of vitamin D3 in the skin under influence of UV light decreases with aging due to insufficient sunlight exposure, and a decreased functional capacity of the skin. Deficiency in vitamin D causes secondary hyperparathyroidism, high bone turnover, bone loss, mineralization defects, proximal myopathy, falls and hip and other fractures. The goal of therapy of hypovitaminosis D is to restore normal serum and deposits of 25 (OH) D. The daily supplementation of vitam...
Source: Aging Clinical and Experimental Research - September 18, 2013 Category: Geriatrics Authors: Resmini G, Tarantino U, Iolascon G Tags: Aging Clin Exp Res Source Type: research

Proximal myopathy: diagnostic approach and initial management
Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs. There is a broad range of underlying causes including drugs, alcohol, thyroid disease, osteomalacia, idiopathic inflammatory myopathies (IIM), hereditary myopathies, malignancy, infections and sarcoidosis. Clinical assessment should aim to distinguish proximal myopathy from other conditions that can present similarly, identify patients who need prompt attention, like those with cardiac, respiratory or pharyngeal muscle involvement, and determine underlying cause of myopathy. Initial evaluation should include simple tests, like creatine...
Source: Postgraduate Medical Journal - July 16, 2013 Category: Journals (General) Authors: Suresh, E., Wimalaratna, S. Tags: Reviews Source Type: research

Adult osteomalacia: A treatable cause of "fear of falling" gait
A 65-year-old man was hospitalized with a gait disorder, obliging him to shuffle laterally1 (video on the Neurology® Web site at www.neurology.org) because of pain and proximal limb weakness. He had a gastrectomy for cancer 7 years previously, with severe vitamin D deficiency; parathormone and alkaline phosphatase were increased, with reduced serum and urine calcium and phosphate. There was reduced bone density (figure). He was mildly hypothyroid and pancytopenic. B12 and folate levels were normal. Investigation for an endocrine neoplasm (CT scan, Octreoscan) was negative. EMG of proximal muscles was typical for chroni...
Source: Neurology - May 27, 2013 Category: Neurology Authors: Ripellino, P., Terazzi, E., Bersano, E., Cantello, R. Tags: Endocrine, Gastrointestinal, Gait disorders/ataxia, Muscle disease, All Neuropsychology/Behavior VIDEO NEUROIMAGES Source Type: research

Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior.
Abstract We hypothesized that zebrafish (Danio rerio) undergoing long-term vitamin E deficiency with marginal vitamin C status would develop myopathy resulting in impaired swimming. Zebrafish were fed for 1 y a defined diet without (E-) and with (E+) vitamin E (500mg α-tocopherol/kg diet). For the last 150days, dietary ascorbic acid concentrations were decreased from 3500 to 50mg/kg diet and the fish sampled periodically to assess ascorbic acid concentrations. The ascorbic acid depletion curves were faster in the E- compared with E+ fish (P<0.0001); the estimated half-life of depletion in the E- fish was 34day...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - May 1, 2013 Category: Biochemistry Authors: Lebold KM, Löhr CV, Barton CL, Miller GW, Labut EM, Tanguay RL, Traber MG Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: research

Hypophosphatasia
(HPP) reveals a critical role for the “tissue-nonspecific” isoenzyme of alkaline phosphatase (TNSALP) in skeletal mineralization. Its biochemical hallmark, subnormal serum ALP activity, results from loss-of-function mutation(s) within TNSALP, the gene that encodes TNSALP. HPP spans an extraordinary range of severity partly explained by autosomal recessive versus autosomal dominant or recessive transmission causing severe and mild HPP, respectively. Perinatal HPP is usually fatal due to profound skeletal hypomineralization. Infantile HPP presents before the age of 6 months with rickets, failure-to-thrive, and sometimes...
Source: Seminars in Arthritis and Rheumatism - February 11, 2013 Category: Rheumatology Authors: Michael Whyte Tags: Conference Proceedings Source Type: research

Improving the Vitamin D Status of Vitamin D Deficient Adults Is Associated With Improved Mitochondrial Oxidative Function in Skeletal Muscle.
Conclusions:Cholecalciferol therapy augments muscle mitochondrial maximal oxidative phosphorylation after exercise in symptomatic, vitamin D-deficient individuals. This finding suggests that changes in mitochondrial oxidative phosphorylation in skeletal muscle could at least be partly responsible for the fatigue experienced by these patients. For the first time, we demonstrate a link between vitamin D and the mitochondria in human skeletal muscle. PMID: 23393184 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 7, 2013 Category: Endocrinology Authors: Sinha A, Hollingsworth KG, Ball S, Cheetham T Tags: J Clin Endocrinol Metab Source Type: research

Vitamin D deficiency: A forgotten treatable cause of motor delay and proximal myopathy
We report a four-year-old African boy referred for proximal muscle weakness, fatigability and episodic limb pain. Classical causes of structural and metabolic myopathy were initially considered before clinical and biological features of vitamin D deficiency rickets were identified. Prompt treatment with vitamin D and calcium supplementation led to a complete reversal of the muscle symptoms. Rickets-associated myopathy should be included in the differential diagnosis of proximal myopathy, especially in at-risk individuals. Vitamin D deficiency and its prevention remain important health issues in industrialized countries.
Source: Brain and Development - December 28, 2012 Category: Neurology Authors: Joel Fluss, Ilse Kern, Geraldo de Coulon, Elsa Gonzalez, Hassib Chehade Tags: Case reports Source Type: research

Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?
CONCLUSIONS: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. PMID: 23240627 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - December 14, 2012 Category: Addiction Authors: Wijnia JW, Wielders JP, Lips P, van de Wiel A, Mulder CL, Nieuwenhuis KG Tags: Alcohol Clin Exp Res Source Type: research