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Myotilinopathy unmasked by statin treatment: A case report
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 20, 2018 Category: Internal Medicine Authors: Alba Ramos ‐Fransi, Alicia Martínez‐Piñeiro, Míriam Almendrote, Giuseppe Lucente, Cristina Carrato, Alfonsina Ballester‐Lopez, Alejandro Lucia, Guillem Pintos‐Morell, Gisela Nogales‐Gadea, Jaume Coll‐Cantí Tags: Noteworthy Cases Source Type: research

Anterior cruciate ligament tear induces a sustained loss of muscle fiber force production
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 19, 2018 Category: Internal Medicine Authors: Jonathan P Gumucio, Kristoffer B Sugg, Elizabeth R Sibilsky Enselman, Alexis C Konja, Logan R Eckhardt, Asheesh Bedi, Christopher L Mendias Tags: Short Report Source Type: research

Untangling the Complexity of Limb ‐girdle Muscular Dystrophies
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 19, 2018 Category: Internal Medicine Authors: Teerin Liewluck, Margherita Milone Tags: Invited Review Source Type: research

The role of electrodiagnosis with long exercise test in McArdle disease
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 19, 2018 Category: Internal Medicine Authors: Claudio Semplicini, Marianne H ézode‐Arzel, Pascal Laforêt, Anthony Béhin, Sarah Leonard‐Louis, Jean‐Yves Hogrel, François Petit, Bruno Eymard, Tanya Stojkovic, Emmanuel Fournier Tags: Clinical Research Article Source Type: research

Effect of dys ‐1 mutation on gene expression profile in space‐flown C. elegans
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 18, 2018 Category: Internal Medicine Authors: Dan Xu, Ying Gao, Lin Guo, Chenggang Lin, Yeqing Sun Tags: Basic Science Research Article Source Type: research

Duchenne muscular dystrophy caused by a novel deep intronic DMD mutation
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 18, 2018 Category: Internal Medicine Authors: Matthew R. Ginsberg, Andrew J. McCarty, David Lacomis, Hoda Z. Abdel ‐Hamid Tags: Noteworthy Cases Source Type: research

Anti ‐HMGCR autoantibody positive necrotizing autoimmune myopathy with dermatomyositis‐like eruption
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 18, 2018 Category: Internal Medicine Authors: Prachi Parikh, Jinny Tavee, Payam Soltanzadeh, Andrew L. Mammen, Paul McKeever, Yuebing Li Tags: Noteworthy Cases Source Type: research

Collagen XII myopathy with rectus femoris atrophy and collagen XII retention in fibroblasts
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 17, 2018 Category: Internal Medicine Authors: Nanna Witting, Thomas Krag, Ulla Werlauff, Morten Duno, Sofie Thuroe Oestergaard, Julia Rebecka Dahlqvist, John Vissing Tags: Short Report Source Type: research

The Neuromuscular Complications of Immune Checkpoint Inhibitor Therapy
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 17, 2018 Category: Internal Medicine Authors: Noah A. Kolb, Christopher R Trevino, Waqar Waheed, Fatemeh Sobhani, Kara K. Landry, Alissa A. Thomas, Mike Hehir Tags: Invited Review Source Type: research

Fatigue is a relevant outcome in patients with Myasthenia Gravis
Abstract Introduction: Patients with myasthenia gravis often experience fatigue, but its effect on quality of life (QoL) is underestimated, and fatigue is rarely measured in clinical trials. Methods: 257 myasthenic patients completed the Neuro‐QoL‐Fatigue and measures of disease severity and QoL. We studied the relationship between fatigue, clinical, and demographic variables. Finally, we studied the responsiveness of the Neuro‐QoL‐Fatigue in 95 patients receiving treatments for myasthenia, and estimated the minimal important difference (MID). Results: Fatigue was correlated with greater disease severity (r=0.52–0.69, P
Source: Muscle and Nerve - January 17, 2018 Category: Internal Medicine Authors: Christopher Tran, Vera Bril, Hans D. Katzberg, Carolina Barnett Tags: Clinical Research Article Source Type: research

Non ‐motor manifestations in ALS patients with tracheostomy and invasive ventilation
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 17, 2018 Category: Internal Medicine Authors: Nazem Atassi Tags: Editorial Source Type: research

Validation of the Individualized Neuromuscular Quality of Life in Japanese patients with myotonic dystrophy
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 17, 2018 Category: Internal Medicine Authors: Haruo Fujino, Toshio Saito, Masanori P. Takahashi, Hiroto Takada, Takahiro Nakayama, Katsuhisa Ogata, Michael R. Rose, Osamu Imura, Tsuyoshi Matsumura Tags: Clinical Research Article Source Type: research

AANEM Application
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 13, 2018 Category: Internal Medicine Tags: AANEM Application Source Type: research

Calendar of Events
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 13, 2018 Category: Internal Medicine Tags: Calendar of Events Source Type: research

AANEM News and Insights
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 13, 2018 Category: Internal Medicine Tags: AANEM News and Insights Source Type: research

Goodbye to neuromuscular images
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 13, 2018 Category: Internal Medicine Authors: Zachary Simmons Tags: Editorial Source Type: research

Issue Information
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 13, 2018 Category: Internal Medicine Tags: Issue Information Source Type: research

Myotonic Dystrophy Patient Preferences in Patient ‐Reported Outcome Measures
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 12, 2018 Category: Internal Medicine Authors: Chad Heatwole, Nicholas Johnson, Jeanne Dekdebrun, Nuran Dilek, Kate Eichinger, James Hilbert, Elizabeth Luebbe, William Martens, Michael P. McDermott, Charles Thornton, Richard Moxley Tags: Clinical Research Article Source Type: research

Ultrasonographic demonstration of intraneural neovascularization after penetrating nerve injury
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 12, 2018 Category: Internal Medicine Authors: Zsuzsanna Ar ányi, Anita Csillik, Katalin Dévay, Maja Rosero Tags: Clinical Research Article Source Type: research

Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open ‐Access ALS Clinical Trials cohort
Discussion: Variable curvilinearity of ALSFRS‐R trajectories confounds interpretation in clinical studies that assume linear decline. Subscore trajectories recapitulate phenotypic diversity and topographical progression of ALS. ALSFRS‐R is better used as a multidimensional measure. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 11, 2018 Category: Internal Medicine Authors: Nimish J. Thakore, Brittany R. Lapin, Erik P. Pioro, Tags: Clinical Research Article Source Type: research

Double Seropositive Myasthenia Gravis: A 5 ‐Year Follow‐Up
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 11, 2018 Category: Internal Medicine Authors: Vasiliki Zouvelou Tags: Letter to the Editor Source Type: research

Pain in SCN4A Mutated P.A1156T muscle sodium channelopathy —a postal survey
Discussion: This sodium channelopathy is another entity in the growing number of diseases causing widespread myalgic pain that resembles the pain seen in fibromyalgia syndrome. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 11, 2018 Category: Internal Medicine Authors: Kimmo Suokas, Johanna Palmio, Satu Sandell, Bjarne Udd, Aki Hietaharju Tags: Short Reports Source Type: research

Aging Impairs Regulation of Ryanodine Receptors from EDL but not Soleus Muscles
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 9, 2018 Category: Internal Medicine Authors: Angela J. Gaboardi, Jochen Kressler, Teresa K. Snow, Edward M. Balog Tags: Short Report Source Type: research

Outcomes Following Surgery for Peroneal Intraneural Ganglion Cysts
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 9, 2018 Category: Internal Medicine Authors: Thomas J. Wilson, Michelle L. Mauermann, Michael G. Rock, Robert J. Spinner Tags: Clinical Research Article Source Type: research

Time ‐course study of macrophage infiltration and inflammation in cast immobilization‐induced atrophied muscle of mice
Abstract Introduction Macrophage infiltration may play an important role in mediating the development of muscle atrophy. However, temporal differences in the activation of muscle atrophy signaling pathways and the progress of macrophage infiltration during the atrophic phases of cast immobilization are currently unknown. Methods C57BL/6J mice were sacrificed after cast immobilization at 1, 3, 7, and 14 days. Results Skeletal muscle macrophage numbers were unchanged on days 1 and 3 after immobilization, but were elevated on days 7 (2.7‐fold, p 
Source: Muscle and Nerve - January 9, 2018 Category: Internal Medicine Authors: Noriaki Kawanishi, Tomoko Funakoshi, Shuichi Machida Tags: Basic Science Research Article Source Type: research

Toenail mercury levels are associated with amyotrophic lateral sclerosis (ALS) risk
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 4, 2018 Category: Internal Medicine Authors: Angeline S. Andrew, Celia Y. Chen, Tracie A. Caller, Rup Tandan, Patricia L. Henegan, Brian P. Jackson, Brenda P. Hall, Walter G. Bradley, Elijah W. Stommel Tags: Clinical Research Article Source Type: research

Sarcolemmal excitability changes in normal human aging
Abstract Introduction: The exact mechanisms underlying the loss of skeletal muscle bulk and power with normal human aging are not well established. Muscle velocity recovery cycles (MVRC) is an in vivo neurophysiological technique which we employed to assess the impact of age on sarcolemmal excitability. Methods: MVRC recordings were obtained from tibialis anterior (n=74) and rectus femoris (n=32) muscles from 74 healthy subjects (18‐84 years, median age 35, interquartile range 29‐55) Results: Increasing age was linearly associated with longer muscle relative refractory period (MRRP) and reduced early supernormality (ES...
Source: Muscle and Nerve - January 4, 2018 Category: Internal Medicine Authors: James HF Lee, Robert Boland ‐Freitas, Karl Ng Tags: Clinical Research Article Source Type: research

Electrophysiological characteristics of the frontal nerve in patients with herpetic ophthalmic neuralgia
ABSTRACT Introduction: The aim of this study was to explore a method for obtaining sensory nerve action potentials (SNAPs) of the supratrochlear (STN) and supraorbital (SONs) nerves and evaluate the function of affected nerves in patients with herpetic ophthalmic neuralgia (HON). Methods: Thirty healthy volunteers and 40 subjects with subacute HON participated in this study. Results: The amplitudes and sensory conduction velocities (SCVs) that predicted HON were identified. The corresponding cut‐off values for the amplitudes ranged from 11.10 μV to 12.45 μV. The corresponding cut‐off values for the SCVs ranged fr...
Source: Muscle and Nerve - January 4, 2018 Category: Internal Medicine Authors: Gang Xu, Chaosheng Zhou, Shasha Liu, Wen Li, Weizhen Tang Tags: Clinical Research Article Source Type: research

Unilateral winged scapula: Clinical and electrodiagnostic experience with 128 cases, with special attention to long thoracic nerve palsy
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 4, 2018 Category: Internal Medicine Authors: Paul Seror, Timoth ée Lenglet, Christelle Nguyen, Michaël Ouaknine, Marie Martine Lefevre‐Colau Tags: Clinical Research Article Source Type: research

Magnetic resonance imaging in facioscapulohumeral muscular dystrophy
(Source: Muscle and Nerve)
Source: Muscle and Nerve - January 1, 2018 Category: Internal Medicine Authors: Doris G. Leung Tags: Editorial Source Type: research

Neuralgic Amyotrophy in children
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 1, 2018 Category: Internal Medicine Authors: Fouad Al ‐Ghamdi, Partha S. Ghosh Tags: Clinical Research Article Source Type: research

Guillain ‐Barré syndrome subtype diagnosis: A prospective multicentric European study
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 1, 2018 Category: Internal Medicine Authors: Peter Y. K. Van den Bergh, Fran çoise Piéret, John L. Woodard, Shahram Attarian, Aude‐Marie Grapperon, Guillaume Nicolas, Marion Brisset, Julien Cassereau, Yusuf A. Rajabally, Vinciane Van Parijs, Donatienne Verougstraete, Philippe Jacquerye, Jean‐M Tags: Clinical Research Article Source Type: research

The high frequency of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 1, 2018 Category: Internal Medicine Authors: Alon Abraham, Carolina Barnett, Hans D. Katzberg, Leif E. Lovblom, A. Perkins Bruce, Vera Bril Tags: Short Report Source Type: research

An 8 ‐generation family with X‐linked Charcot–Marie–Tooth: Confirmation Of the pathogenicity Of a 3′ untranslated region mutation in GJB1 and its clinical features
Discussion: The c.*15C>T mutation in the GJB1 3′ UTR segregates with CMTX1 in 8 generations. Penetrance in males and females is essentially complete. A straightforward genetic method to detect this mutation is described. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 28, 2017 Category: Internal Medicine Authors: Dong ‐Hui Chen, Maxwell Ma, Mena Scavina, Elizabeth Blue, John Wolff, Prasanthi Karna, Michael O. Dorschner, Wendy H. Raskind, Thomas D. Bird Tags: Short Reports Source Type: research

3,4 ‐Diaminopyridine Base Effectively Treats the Weakness of Lambert‐Eaton Myasthenia
ABSTRACT Introduction: 3,4‐diaminopyridine has been used to treat Lambert Eaton myasthenia (LEM) for thirty years despite the lack of conclusive evidence of efficacy. Methods: We conducted a randomized double‐blind placebo‐controlled withdrawal study in LEM patients who had been on stable regimens of 3,4‐diaminopyridine base (3,4‐DAP) for ≥ 3 months. The primary efficacy endpoint was>30% deterioration in Triple Timed Up‐and‐Go (3TUG) times during tapered drug withdrawal. The secondary endpoint was self‐assessment of LEM–related weakness (W‐SAS). Results: 32 participants were rand...
Source: Muscle and Nerve - December 27, 2017 Category: Internal Medicine Authors: Donald B Sanders, Vern C Juel, Yadollah Harati, A. Gordon Smith, Amanda C Peltier, Tessa Marburger, Jau ‐Shin Lou, Robert M Pascuzzi, David P Richman, Tai Xie, Valentin Demmel, Laura R Jacobus, Kathy L Aleš, David P Jacobus, Tags: Clinical Research Article Source Type: research

Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 23, 2017 Category: Internal Medicine Authors: Jennifer M. Martinez ‐Thompson, Melissa R. Snyder, Michael Ettore, Andrew McKeon, Sean J. Pittock, Matthew M. Roforth, Jay Mandrekar, Michelle L. Mauermann, Bruce V. Taylor, P. James B. Dyck, Anthony J. Windebank, Christopher J. Klein Tags: Basic Science Research Article Source Type: research

Pain in SCN4A mutated p.A1156T muscle sodium channelopathy ‐ a postal survey
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Kimmo Suokas, Johanna Palmio, Satu Sandell, Bjarne Udd, Aki Hietaharju Tags: Short Report Source Type: research

Calcium Channel Autoimmunity: Cerebellar Ataxia and Lambert ‐Eaton Syndrome Coexisting
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Nicholas Zalewski, Vanda A. Lennon, Sean J. Pittock, Andrew McKeon Tags: Clinical Research Article Source Type: research

Quality of Care and Patient ‐reported Outcomes in Carpal Tunnel Syndrome: A Prospective Observational Study
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Teryl K. Nuckols, Craig Conlon, Michael Robbins, Michael Dworsky, Julie Lai, Carol P. Roth, Barbara Levitan, Seth Seabury, Rachana Seelam, Douglas Benner, Steven M. Asch Tags: Clinical Research Article Source Type: research

Reply
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Adam Aubuchon, W. David Arnold, J. Chad Hoyle Tags: Letters to the Editor Source Type: research

HIV, antiretrovirals, and peripheral neuropathy: A moving target
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Michelle Kaku, David M. Simpson Tags: Editorial Source Type: research

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice
Discussion: We propose that a dysregulation in the miRNA/totRNA ratio in the TA muscle from SOD1G93A mice reflects a pathological increase in miRNA biogenesis machinery. Alterations in the miRNA/totRNA ratio influence the levels of reference noncoding RNAs and may therefore potentially compromise the accuracy of commonly used miRNA normalization strategies. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 22, 2017 Category: Internal Medicine Authors: Aaron P. Russell, Lobna Ghobrial, Shyuan Ngo, Justin Yerbury, Evelyn Zacharewicz, Roger Chung, S éverine Lamon Tags: Basic Science Research Article Source Type: research

Non ‐volitional assessment of tibialis anterior force and architecture during critical illness
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 21, 2017 Category: Internal Medicine Authors: Bronwen Connolly, Matthew Maddocks, Victoria MacBean, William Bernal, Nicholas Hart, Philip Hopkins, Gerrard F Rafferty Tags: Clinical Research Article Source Type: research

Risk Factors for Acute Nerve Injury after Total Knee Arthroplasty1
This study identifies potential risk factors for post‐total knee arthroplasty (TKA) nerve injury, a catastrophic complication with a reported incidence of 0.3% to 1.3%. Methods: Patients who developed post‐TKA nerve injury from 1998 to 2013 were identified, and each was matched with 2 controls. A multivariable logistic regression model was built to calculate odds ratios (OR). Results: 65 nerve injury cases were identified in 39,990 TKAs (0.16%). Females (OR 3.28, p=0.003) and patients with history of lumbar pathology (OR 6.12, p=0.026) were associated with increased risk of nerve injury. Tourniquet pressure
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Teena Shetty, Joseph T. Nguyen, Mayu Sasaki, Anita Wu, Eric Bogner, Alissa Burge, Taylor Cogsil, Aashka Dalal, Kristin Halvorsen, Kelianne Cummings, Edwin P. Su, Stephen Lyman Tags: Clinical Research Article Source Type: research

A Muscle Strength Enhancer for All Seasons?
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Leo H. Wang, Michael D. Weiss Tags: Editorial Source Type: research

Neurologic examination and instrument ‐based measurements in the evaluation of ulnar neuropathy at the elbow
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Gregor Omejec, Simon Podnar Tags: Clinical Research Article Source Type: research

The difficulties and importance of research in rare genetic diseases
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Michael Hunter, Nicholas E Johnson Tags: Editorial Source Type: research

Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Doris G. Leung, Xin Wang, Peter B. Barker, John A. Carrino, Kathryn R. Wagner Tags: Clinical Research Article Source Type: research

15 ‐year longitudinal follow‐up of a patient with severe early‐onset Charcot‐Marie‐Tooth disease type 2A
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Brett A. McCray, William Hurst, Crawford O. Thomas, Thomas E. Lloyd Tags: Noteworthy Cases Source Type: research

Myofibrillar myopathy due to dominant LMNA mutations: A report of 2 cases
(Source: Muscle and Nerve)
Source: Muscle and Nerve - December 20, 2017 Category: Internal Medicine Authors: Priya S. Dhawan, Teerin Liewluck, Joseph Knapik, Margherita Milone Tags: Noteworthy Cases Source Type: research