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Condition: Polymyositis
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Total 420 results found since Jan 2013.
Which nonautoimmune myopathies are most frequently misdiagnosed as myositis?
Purpose of review: To discuss the spectrum of nonautoimmune myopathies that may be misdiagnosed as autoimmune myopathy.
Recent findings: Inherited myopathies, such as dysferlinopathy, calpainopathy, and facioscapulohumeral dystrophy may be misdiagnosed as autoimmune myopathy, especially when they have inflammatory muscle biopsies. Inclusion body myositis is frequently misdiagnosed as polymyositis when rimmed vacuoles are absent on muscle biopsy, and a careful neuromuscular evaluation is not performed. Hypothyroid myopathy can be misdiagnosed as immune-mediated necrotizing myopathy if thyroid function tests, including a T4...
Source: Current Opinion in Rheumatology - October 10, 2017 Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Ingrid E. Lundberg and Jiri Vencovsky Source Type: research
Anti-HMGCR antibody positive myopathy shows bcl-2-positive lymphocyte follicles
Idiopathic inflammatory myopathies (IIM) are classified in five categories including polymyositis (PM), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and non-specific myositis. Muscle pathologies are required elements for the classification of IIM. In addition to the pathological patterns, more than 15 autoantibodies specific for myositis are already recognized. Recently, Anti-HMG-CoA reductase (HMGCR) antibody is reported to be one of the myositis-specific autoantibodies.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: T. Kurashige, N. Sumi, T. Kanbara, M. Ohta, T. Sugiura, H. Maruyama, T. Torii Source Type: research
Idiopathic inflammatory myopathies – increased expression of heat shock protein-90 in muscle tissue and plasma correlates with disease activity and skeletal muscle involvement
Heat shock proteins (Hsp) are chaperones playing important roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. The aim of our study was to assess Hsp90 expression in muscle biopsies and plasma of patients with idiopathic inflammatory myopathies (IIM) and to characterize its association with IIM-related features. Total of 277 patients with IIM (dermatomyositis (DM, 104); polymyositis (PM, 104); cancer associated myositis (CAM, 42); necrotizing myopathy (IMNM, 27)), and 100 age-/sex-matched healthy individuals were included in Hsp90 plasma analysis by ELISA.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: J. Zamecnik, H. Storkanova, O. Krystufkova, M. Klein, H. Mann, L. Vernerova, M. Spiritovic, L. Senolt, J. Vencovsky, M. Tomcik Source Type: research
Differential type I and type II interferon signatures in primary inflammatory/dysimmune myopathies
Primary inflammatory/dysimmune myopathies (PIDM) include (i) polymyositis (PM)/inclusion body myositis (IBM), (ii) dermatomyositis (DM), (iii) necrotizing autoimmune myopathy, and (iv) overlap myositis (OM) . Type I α/β interferon signature was proposed as a characteristic feature of DM . Since OM and IBM differ from other PIDM by the presence of major histocompatibility complex (MHC)-2 expression by myofibers, we hypothesized that they are characterized by interferon (IFN)γ-mediated inflammation.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: M. Rigolet, C. Hou, B. Periou, P. Muhammad, R. Gherardi, Y. Baba Amer, F. Authier Source Type: research
Late onset multiple acyl-CoA dehydrogenase deficiency (MADD) myopathy misdiagnosed as polymyositis
We present a patient affected by a late onset MADD myopathy misdiagnosed for several years as polymyositis unresponsive to immunosuppressant therapies. The first symptoms started in his 40s with a slow progressive fatigability associated with occasional cramps in the calves; initial investigations showed high CPK level (1000 –1500 UI/L) without significant anomaly on muscle biopsy.
Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: A. Barp, R. Bellance, O. Rigal, C. Acquaviva-Bourdain, P. Lafor êt Source Type: research
A review of inflammatory idiopathic myopathy focusing on polymyositis
Inflammatory idiopathic myopathies are a group of autoimmune diseases affecting predominantly the proximal skeletal muscles, with raised muscle enzymes, with or without skin involvement and extramuscular organ involvement. Autoantibodies help to characterize patients into different clinical phenotypes. Successful treatment necessitates controlling inflammation early with corticosteroids and invariably requires additional immunosuppressive therapy. This review focuses on the aetiology, pathogenesis, clinical presentation, investigations and management of patients presenting with inflammatory idiopathic myopathies, predomina...
Source: European Journal of Neurology - August 17, 2017 Category: Neurology Authors: K. E. N. Clark, D. A. Isenberg Tags: Review Article Source Type: research
Statin ‐associated immune mediated necrotising myopathy: a New Zealand case series showing possible over‐representation in Pacific Islanders
ConclusionThis is the first case series of statin‐associated IMNM with a focus on Pacific Islanders, and raises the possibility that Pacific Islanders exposed to statins may be at increased risk of developing an immune mediated myopathy.
Source: Internal Medicine Journal - August 7, 2017 Category: Internal Medicine Authors: Michelle Claudine Woolley, Simon Stebbings, John Highton Tags: Original Article Source Type: research
Acute heart failure and rhabdomyolysis: a clue for the diagnosis of polymyositis with cardiac involvement.
We report the case of a 51-year-old male, with history of complete heart block, which required pacemaker implantation, and subsequently heart failure, presenting to the emergency department with worsening of dyspnea and peripheral edema. He was admitted to the Internal Medicine ward with acute heart failure and started on diuretic therapy. During hospitalization, he was discovered to have marked rhabdomyolysis. Examination revealed proximal symmetrical muscle weakness and arthralgia. The immunological study, electromyography and muscle biopsy confirmed polymyositis. The patient was started on prednisolone with clinical imp...
Source: Reumatismo - August 3, 2017 Category: Rheumatology Authors: Pinto-Lopes P, Carneiro-Leão L, Morais R, Pinheiro J, Vieira Lopes A, Bettencourt P Tags: Reumatismo Source Type: research
Diagnosis of dermatomyositis: Autoantibody profile and muscle pathology
Abstract
Dermatomyositis (DM) is an idiopathic inflammatory myopathy, which not only affects skeletal muscle and skin, but it is also associated with arthritis/arthralgia, interstitial lung disease and cancer. The diagnostic criteria for myositis that Bohan and Peter formulated in 1975, which are often still used now, depend on the presence of a characteristic skin rash for classification of DM; without it, a diagnosis of polymyositis is given. However, advances in understanding the etiology of idiopathic inflammatory myopathies over the past few decades are impressive, encompassing discovery of myositis‐specific/associa...
Source: Clinical and Experimental Neuroimmunology - August 1, 2017 Category: Neurology Authors: Akinori Uruha, Shigeaki Suzuki, Ichizo Nishino Tags: Review Article Source Type: research
Dermatomyositis Induced by Hepatitis B Virus-related Hepatocellular Carcinoma: A Case Report and Review of the Literature.
Authors: Chou JW, Lin YL, Cheng KS, Wu PY, Reanne Ju T
Abstract
Dermatomyositis or polymyositis as a paraneoplastic syndrome of hepatocellular carcinoma (HCC) is an uncommon event. Few cases have been reported in the literature. We herein report the case of a 55-year-old man with chronic hepatitis B and alcoholism who presented with skin rash. Abdominal computed tomography revealed multiple hypervascular liver tumors consistent with HCC. He subsequently developed dysphagia with proximal limb weakness. Laboratory tests and electromyography demonstrated inflammatory myopathy. We therefore diagnosed the patient with H...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research
Progressive hypoventilation due to mixed CD8 + and CD4 + lymphocytic polymyositis following tremelimumab - durvalumab treatment
ConclusionsThis case supports the hypothesis that muscle tissue is a target for lymphocytic infiltration in immune checkpoint inhibitor-associated polymyositis. Further insights into the autoimmune mechanism of PM will hopefully contribute to the prevention and treatment of this phenomenon.
Source: Journal for Immunotherapy of Cancer - July 18, 2017 Category: Cancer & Oncology Source Type: research
Autoantibodies to Su/Argonaute 2 in Japanese patients with inflammatory myopathy
Conclusion Our novel ELISA appears to be useful for screening anti-Su/Ago2 antibodies (sensitivity: 93%, specificity: 79%).
Source: Clinica Chimica Acta - July 4, 2017 Category: Laboratory Medicine Source Type: research
Outcome measures in the idiopathic inflammatory myopathies: On the search for the holy grail
The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare autoimmune disorders that share some similarities, such as proximal predominant symmetric muscle weakness, also known as myopathy pattern 1,1 except for myopathy pattern 4 (distal arm and proximal leg weakness), in inclusion body myositis (IBM).1,2 Common features in IBM, dermatomyositis, polymyositis, and necrotizing autoimmune myopathy, frequently include serum creatine kinase (CK) elevation and myopathy with muscle membrane irritability on EMG. Muscle histopathology findings vary depending on the underlying disease, and may include inflammato...
Source: Neurology - July 3, 2017 Category: Neurology Authors: Dimachkie, M. M., Paganoni, S. Tags: Outcome research, Autoimmune diseases, Muscle disease, Clinical trials Methodology/study design EDITORIALS Source Type: research
Autoantibodies to Su/Argonaute 2 in Japanese patients with inflammatory myopathy.
CONCLUSION: Our novel ELISA appears to be useful for screening anti-Su/Ago2 antibodies (sensitivity: 93%, specificity: 79%).
PMID: 28673815 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - June 30, 2017 Category: Chemistry Authors: Ogawa-Momohara M, Muro Y, Satoh M, Akiyama M Tags: Clin Chim Acta Source Type: research
Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis
This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128...
Source: Rheumatology International - May 10, 2017 Category: Rheumatology Source Type: research
