Differential type I and type II interferon signatures in primary inflammatory/dysimmune myopathies

Primary inflammatory/dysimmune myopathies (PIDM) include (i) polymyositis (PM)/inclusion body myositis (IBM), (ii) dermatomyositis (DM), (iii) necrotizing autoimmune myopathy, and (iv) overlap myositis (OM) . Type I α/β interferon signature was proposed as a characteristic feature of DM . Since OM and IBM differ from other PIDM by the presence of major histocompatibility complex (MHC)-2 expression by myofibers, we hypothesized that they are characterized by interferon (IFN)γ-mediated inflammation.

Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: M. Rigolet, C. Hou, B. Periou, P. Muhammad, R. Gherardi, Y. Baba Amer, F. Authier Source Type: research