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Condition: Polymyositis

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Total 420 results found since Jan 2013.

PET Scan: Nuclear Medicine Imaging in Myositis
AbstractPurpose of ReviewPositron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with inflammatory myopathy.Recent FindingsCancer screening by PET/CT seems suitable and cost-effective in patients with myositis. It has also shown value as a hybrid technique for diagnosing myositis versus controls and could be of interest for differentiating between polymyositis and sporadic inclusion bo...
Source: Current Rheumatology Reports - November 20, 2019 Category: Rheumatology Source Type: research

Human muscle pathology is associated with altered phosphoprotein profile of mitochondrial proteins in the skeletal muscle.
Abstract Analysis of human muscle diseases highlights the role of mitochondrial dysfunction in the skeletal muscle. Our previous work revealed that diverse upstream events correlated with altered mitochondrial proteome in human muscle biopsies. However, several proteins showed relatively unchanged expression suggesting that post-translational modifications, mainly protein phosphorylation could influence their activity and regulate mitochondrial processes. We conducted mitochondrial phosphoprotein profiling, by proteomics approach, of healthy human skeletal muscle (n = 10) and three muscle diseases (n = 10 ...
Source: Journal of Proteomics - October 22, 2019 Category: Biochemistry Authors: Sunitha B, Kumar M, Gowthami N, Unni S, Gayathri N, Prasad TSK, Nalini A, Polavarapu K, Vengalil S, Preethish-Kumar V, Padmanabhan B, Bharath MMS Tags: J Proteomics Source Type: research

Muscle aches and pains: do I have leukemia?
We describe a 65-year-old man who presented with 'aches and pains' localized to the lower extremities, and was diagnosed with acute myeloid leukemia (AML). We hypothesize that this case represents an atypical presentation of AML with an immune-mediated necrotizing-like myopathy as a possible paraneoplastic manifestation of the disease, which improved after initiating chemotherapy. Our patient received a full course of 7 + 3 chemotherapy with cytarabine and daunorubicin. Proximal leg weakness and pain improved markedly following this treatment, establishing a temporal relationship between the possible paraneoplastic man...
Source: International Journal of Hematology - October 13, 2019 Category: Hematology Authors: Deschner M, Phua C, Saini L, Xenocostas A, Deotare U Tags: Int J Hematol Source Type: research

P.20Expanding the myasthenia-myositis association spectrum: clinical, morphological and immunological data form a large case series
Myastenia-inflammatory myopathy (MG-IM) association has been described in less than 50 cases, as isolated reports or in few case series. In most cases, MG and IM onset occur simultaneously even if the overlapping clinical manifestations could lead to delay the diagnosis in the early stage of disease. In these cases, thymic pathology is present in more than 50% of cases. Pathological findings can be consistent of polymyositis (63%), dermatomyositis (25%) or granulomatosis (12%). MSA and muscle MRI involvement have not been systematically investigated.
Source: Neuromuscular Disorders - September 30, 2019 Category: Neurology Authors: M. Garibaldi, L. Fionda, F. Vanoli, L. Leonardi, E. Bucci, S. Morino, G. Merlonghi, M. Lucchini, M. Mirabella, F. Andreetta, E. Pennisi, A. Petrucci, G. Antonini Source Type: research

P.06Muscle ultrasound in patients with inclusion body myositis: differentiating from mimics
In this study we aimed to further evaluate the ability of US to differentiate between IBM and Polymyositis/Dermatomyositis (PM/DM) and neuromuscular disorders using two separate cohorts.
Source: Neuromuscular Disorders - September 30, 2019 Category: Neurology Authors: K. Leeuwenberg, L. Christopher-Stine, J. Paik, E. Tiniakou, C. Mecoli, N. van Alfen, J. Doorduin, C. Saris, J. Albayda Source Type: research

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors
ConclusionsIn inflammatory myopathy associated with PD-1 inhibitors, CD8+ cells appear to predominantly destruct muscle fibers. The presence of lymphoid follicle-like structures and expression of PNAd and CCL21 on the endothelial cells suggest the tertiary lymphoid organs are formed, and involved in the leakage of lymphocytes. Thus, in the three cases examined, formation of the tertiary lymphoid organs is likely to play an important role in genesis of the PD-1 myopathy.
Source: Journal for Immunotherapy of Cancer - September 17, 2019 Category: Cancer & Oncology Source Type: research

Classification of idiopathic inflammatory myopathies: pathology perspectives
Purpose of review Idiopathic inflammatory myopathies (IIM) are rare diseases with heterogenous clinicopathological features. In recent years, new classification systems considering various combinations of clinical, serological, and pathological information have been proposed. This review summarizes recent clinicoseropathological development in major subgroups of IIM. Recent findings Considering clinicoseropathological features, IIM are suggestively classified into four major subgroups: dermatomyositis, immune-mediated necrotizing myopathy (IMNM), antisynthetase syndrome (ASS), and inclusion body myositis (IBM). Many h...
Source: Current Opinion in Neurology - August 29, 2019 Category: Neurology Tags: NEUROMUSCULAR DISEASE: Edited by Michio Hirano Source Type: research

Antisynthetase syndrome presenting as interstitial lung disease: a case report
ConclusionAntisynthetase syndrome is a rare clinical entity which apart from clinical presentation requires specific serological investigations for diagnosis. Concomitant association of interstitial lung disease gives it a guarded prognosis.
Source: Journal of Medical Case Reports - August 3, 2019 Category: General Medicine Source Type: research

Quantitative T2 mapping accelerated by GRAPPATINI for evaluation of muscles in patients with myositis.
CONCLUSION: GRAPPATINI can significantly shorten acquisition time of T2 mapping and may potentially be applied clinically in DM and PM. ADVANCES IN KNOWLEDGE: GRAPPATINI acceleration makes T2 mapping feasible in clinical practice in providing quantitative information regarding thigh muscle inflammation in DM and PM. PMID: 31287733 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - July 8, 2019 Category: Radiology Authors: Wang F, Zhang H, Wu C, Wang Q, Hou B, Sun Y, Kober T, Hilbert T, Zhang Y, Zeng X, Jin Z Tags: Br J Radiol Source Type: research

An Anti-PM/Scl-75 Antibody-positive Japanese Woman who Developed Inflammatory Myopathy.
Authors: Nakamura Y, Miyanaga R, Shizukawa H, Shimohama S Abstract A 69-year-old Japanese woman presented with mild muscle weakness of the neck and symmetrical proximal parts of the upper and lower limbs. Laboratory tests, needle electromyography, and a muscle biopsy revealed inflammatory myopathy with an apparent clinical classification of polymyositis and positive findings for anti-PM/Scl-75 antibody. This antibody is rare among Japanese populations, and most Japanese patients with the antibody are not classified with the inflammatory myopathy seen in polymyositis. The muscle biopsy also showed marked necrotic an...
Source: Internal Medicine - June 11, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Physical therapy in adult inflammatory myopathy patients: a systematic review
AbstractThe safety and effect of physical therapy in adult patients with idiopathic inflammatory myopathies (IIMs) are currently unclear. Considering the muscle weakness resulting from disease activity as well as from the administered drugs, these patients could benefit from an evidence-based physical therapy program. To perform a systematic review to assess safety and effects of physical therapy on the functional outcome of patients with idiopathic inflammatory myopathies in both active and quiescent disease: Pubmed, Embase, and Cochrane. Patients with one of the following idiopathic inflammatory myopathies: polymyositis,...
Source: Clinical Rheumatology - May 20, 2019 Category: Rheumatology Source Type: research

The clinical and histopathological features of idiopathic inflammatory myopathies with asymmetric muscle involvement
The objective is to determine the frequency of idiopathic inflammatory myopathies (IIMs) with asymmetric muscle involvement (IIMs-A) as initial manifestations in total IIMs and to compare the demographic, clinical, histopathological and radiological characteristics of IIMs-A with classical IIMs (IIMs-C). We retrospectively reviewed the clinical, laboratory, muscle images, histopathological features and treatment response of patients at the Qilu hospital who were diagnosed as IIMs from April 2005 to August 2017. We found among 134 IIMs patients, 13(9.2%) patients with IIMs-A were identified, of which 7 patients were diagnos...
Source: Journal of Clinical Neuroscience - May 4, 2019 Category: Neuroscience Source Type: research

Polymyositis with mitochondrial pathology or atypical form of sporadic inclusion body myositis: case series and review of the literature
AbstractPolymyositis with mitochondrial pathology (PM-Mito) is a rare form of idiopathic inflammatory myopathy with no definite diagnostic criteria and similarities to both PM and sporadic inclusion body myositis (s-IBM). The aim of this study is to address the dilemma of whether PM-Mito is a subtype of inflammatory myopathy or represents a disease falling into the spectrum of s-IBM. Herein, we report four female patients diagnosed with PM-Mito, highlighting their rather atypical clinical and histopathological characteristics that seem to indicate a diagnosis away from s-IBM. Muscle weakness was rather proximal and symmetr...
Source: Rheumatology International - May 3, 2019 Category: Rheumatology Source Type: research

Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies
Conclusion: The data hold promise for advancements in standardization of MSA assays as well as for the potential inclusion of MSA in future classification criteria. Introduction Myositis specific (MSA) and myositis associated antibodies (MAA) have been used as an aid in the diagnosis of idiopathic inflammatory myopathies (IIM) for decades (1). Since many of the MSA (e.g., anti-synthetase antibodies), partly depending on the screening dilution, are accompanied by limited sensitivity of the indirect immunofluorescence (IIF) test, this method has limited utility as a screening test for suspected myositis (2–6)...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells
Discussion Treg represent a lineage of T cells which play a fundamental role in maintaining humoral tolerance in the periphery. This subset of “suppressor T cells” is identified as FoxP3-expressing CD4+ T cells (16, 17). The unrestrained expression of FoxP3 is essential for the development and function of Treg (4). Accordingly, a disruption of the Foxp3 gene in scurfy mice results in an autoimmune lymphoproliferative disorder with fatal multi-organ inflammation (18). Since the causative mutation occurs in orthologous genes, the scurfy phenotype is indicated as the murine equivalent of the human IPEX sy...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research